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Crohn's Disease

Groundbreaking Technologies for Life

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  • Diarrhea 

  • Abdominal pains 

  • Intestinal blockages 

  • Fever 

  • Fatigue 

  • Loss of appetite and weight loss 

  • Still feeling full after using the toilet 

  • Frequent toileting is one of the early symptoms of Crohn's disease. 

What Can tVNS® Do for Crohn's?

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" The scientific solution against Crohn's disease and Irritable Bowel Syndrome (IBS): tVNS®
Transcutaneous vagus nerve stimulation has yielded promising results in many patients diagnosed with Crohn's disease and IBS, which are resistant to medication and severely reduce their quality of life. This clinically proven, non-invasive method contributes to the safe management of gastrointestinal symptoms by regulating the gut-brain axis. It stands out as a new treatment option, particularly for chronic intestinal disorders .

  • Diarrhea 

  • Abdominal pains 

  • Intestinal blockages 

  • Fever 

  • Fatigue 

  • Loss of appetite and weight loss 

  • Still feeling full after using the toilet 

  • Frequent toileting is one of the early symptoms of Crohn's disease. 

May reduce the release of proinflammatory cytokines such as TNF-α, IL-1β and IL-6

Can suppress the inflammatory activity of macrophages

It can re-establish the immune balance in the intestinal mucosa

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In a 2016 study conducted by Bonaz and colleagues, seven individuals with active Crohn's disease received chronic vagus nerve stimulation (VNS) therapy for six months. The primary goal of the study was to achieve clinical remission (reduction of CDAI scores), while secondary goals included immune markers (CRP and/or fecal calprotectin) and endoscopic improvement, as well as restoration of vagus nerve tone (as measured by heart rate variability). Stimulation was well tolerated by all patients, with no significant side effects. Two patients were withdrawn from the study three months into treatment due to clinical worsening. The remaining five patients experienced both clinical remission, biological improvement, and endoscopic improvement, and vagal tone was restored. These results provide initial evidence that VNS may be a feasible, safe, and effective treatment option for active Crohn's disease.

What is Crohn's Disease ?

 

Crohn's disease is a type of inflammatory bowel disease that causes inflammation of the gastrointestinal tract from the mouth to the anus. This inflammation can be attached to one or more parts of the digestive system, but it is usually seen in the ileum, which is the last part of the small intestine, and in the beginning of the large intestine. Crohn's disease can cause inflammation in your digestive tract, leading to abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition. 

 

Growth-development retardation in children may be signs of Crohn's disease. Extra-intestinal diseases are also observed in a quarter of Crohn's patients. These mostly occur in the skin, joints, eyes, liver and biliary tract, kidney and urinary tract, vascular heart and lungs. 

Crohn's Disease Symptoms

Crohn's

  • Diarrhea 

  • Abdominal pains 

  • Intestinal blockages 

  • Fever 

  • Fatigue 

  • Loss of appetite and weight loss 

  • Still feeling full after using the toilet 

  • Frequent toileting is one of the early symptoms of Crohn's disease. 

  • Diarrhea 

  • Abdominal pains 

  • Intestinal blockages 

  • Fever 

  • Fatigue 

  • Loss of appetite and weight loss 

  • Still feeling full after using the toilet 

  • Frequent toileting is one of the early symptoms of Crohn's disease. 

Crohn's

Crohn's Disease Diagnostic Methods

  • Blood analysis

  • stool analysis

  • Stomach, small and large intestine films

  • Colonoscopy and endoscopy

  • CT and MRI images

Crohn's Disease Diagnostic Methods

  • Diarrhea 

  • Abdominal pains 

  • Intestinal blockages 

  • Fever 

  • Fatigue 

  • Loss of appetite and weight loss 

  • Still feeling full after using the toilet 

  • Frequent toileting is one of the early symptoms of Crohn's disease. 

Corticosteroids

Immunosuppressants

Aminosalicylates

Biological agents (anti-TNF α)

  • Diarrhea 

  • Abdominal pains 

  • Intestinal blockages 

  • Fever 

  • Fatigue 

  • Loss of appetite and weight loss 

  • Still feeling full after using the toilet 

  • Frequent toileting is one of the early symptoms of Crohn's disease. 

Clinical Response in Human Studies

​
In a study by Bonaz et al. (2016), a significant decrease in disease activity scores (CDAI) was noted in the majority of Crohn's disease patients who underwent tVNS. At 6-month follow-up, clinical remission was achieved in more than 60% of the tVNS group. No side effects were observed in this study, and patients' quality of life also improved.

Changes in Immune Profile and Cytokine Responses

While pro-inflammatory cytokine levels decreased in patients undergoing tVNS, an increase in anti-inflammatory IL-10 levels was detected.

A Drug-Free and Safe Alternative

 
tVNS offers a promising approach, especially for patients who do not respond to immunosuppressive therapy, who are discontinuing medication due to side effects, or who wish to avoid surgery.

Crohn's Disease Causes

​

  • Immune system: It is possible for a virus or bacteria to trigger Crohn's disease; however, scientists have yet to identify such a trigger. When your immune system tries to fight off the invading microorganism, an abnormal immune response can cause the immune system to attack cells in the digestive tract as well. 

  • Heredity: Crohn's disease is more common in people with a family history of the same disease, so genes may play a role in the occurrence of the disease.

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