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tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Tinnitus According to clinical studies conducted in 2000 patients using the tVNS® device between 2010 and 2018, a significant reduction in the severity and number of seizures was observed in an average of 60% of the patients. It can be said that a secondary effect, which is widely seen, is an increase in vitality, cognitive progress and improvement in sleep patterns. It can completely stop seizures in 10-20% of patients. According to clinical studies conducted in 2000 patients using the tVNS® device between 2010 and 2018, a significant reduction in the severity and number of seizures was observed in an average of 60% of the patients. It can be said that a secondary effect, which is widely seen, is an increase in vitality, cognitive progress and improvement in sleep patterns. It can completely stop seizures in 10-20% of patients. In Türkiye, one person has a stroke every 4 minutes. 8% – 39% The lifetime risk of stroke for individuals over the age of 25 varies between 8% and 39% depending on the region. 12,000,000 Approximately 12 million people worldwide experience a first stroke each year. 200,000 Approximately 200,000 people have a stroke every year in Türkiye. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Application and Security Improving Motor Functions It can help regain hand-arm movements. Promoting Neuroplasticity It can strengthen rehabilitation by supporting the formation of new connections between brain cells. Improvement in mood and sleep It may help alleviate symptoms of depression, sleep disturbances, and anxiety that are common after stroke. Cognitive Improvement Treatment It can support improvement in areas such as attention, memory, and learning. Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Contact us Contact us

Transkutanöz Vagus Sinir Stimülasyonu (tVNS), vagus sinirine bir kulakluk yardımıyla elektriksel uyarılar verilmesini içeren tıbbi bir tedavidir . Dirençli epilepsi, kronik migren ve ilaca dirençli depresyon için etkili bir tedavi olarak kullanılır. What is Vagus Nerve? The vagus nerve is the longest cranial nerve in the body. It comes from the Latin word, vagus, for “wandering.” That’s because it wanders throughout your body, with wide distribution connecting the brainstem to the body. Only mammals have this nerve. The vagus nerve serves as the body's superhighway, carrying information between the brain and the internal organs and controlling the body's response in times of rest and relaxation. It helps the immune system and inflammation response to disease. It has four main functions: sensory, special sensory, motor and parasympathetic. The vagus nerve also manages fears and sends information from the gut to the brain, which is linked to dealing with stress, anxiety, and fear–hence the saying, ‘gut feeling'. Discover Historical Development of Vagus Nerve Stimulation Epilepsy has existed in human history with the first record found in a Babylonian text written 4000 years ago, and humanity has sought a cure for this disease for centuries. With the emergence of neurology in the 19th century, the mechanism between the nervous system and epilepsy was tried to be solved and the first vagus nerve stimulation was tried by a New York neurologist in the early 1880s. Over the next 100 years, the effects of vagus nerve stimulation were first investigated in animal experiments, then in humans, and in 1996, the vagus nerve was surgically implanted into the body and become an invasive stimulation option. At the beginning of the 2000s, for eliminating the side effects of invasive VNS, scientists tried to find out ways to stimulate the vagus nerve non-invasively, and by 2010 these studies were concluded successfully. Our first generation device, Nemos, was approved in 2010 for the treatment of epilepsy and depression, and Vitos in 2012 for the treatment of pain and migraine, as the first medically approved non-invasive vagus nerve stimulation treatment in the world. Our 2nd generation device, tVNS-L, has been approved in 2021, and has become a treatment option used in many neurodegenerative diseases. Vagus Nerve Stimulation Effect Overview Regulation of neurotransmitter release Increase in parasympathetic activity Increase in brain neuroplasticity Reducing inflammation Increasing the secretion of serotonin and increasing the mood What Are the Effects of Vagus Nerve Stimulation? Stimulation of the vagus triggers regulatory mechanisms in the nervous, immune, autonomic, endocrine, cardiorespiratory, and gastrointestinal systems. Clinical studies on the vagus nerve have shown that the activity in this nerve is closely related to epilepsy, depression, migraine, headache, inflammatory bowel disease, Alzheimer's, arthritis and many other common disorders by activating the parasympathetic nervous system in the brain and increasing the secretion of neurotransmitters in special regions of the brain. shows. Vagus nerve stimulation therapies are approved by FDA in the USA and CE in Europe for use in treatments such as mood improvement, pain relief, sleep improvement, memory enhancement and anxiety reduction. Research continues on the effects of neuroplasticity as well as its cardiac and inflammatory properties. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır MIGRAINE Groundbreaking Technologies for Life Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. " tVNS treatment provides great support for my balance issues. I can walk about 15 km on the golf course once a week. I still take medication, but I know my balance problems have improved thanks to the tVNS device. "tVNS® is a research-proven, non-invasive treatment option that supports neurological function and can help people with Parkinson's disease stay active, mobile, and engaged in life." Barry H., a Parkinson's patient and tVNS® user, What is Migraine? It is a neurological disorder that causes a throbbing, severe headache, often felt intensely on one side of the head. The distinctive features of migraine that distinguish it from other headaches include nausea and vomiting, and sensitivity to sound and light. The pain is so severe that it interferes with the completion of daily activities and leads to limitation. Migraine attacks take the first place among the most important causes of disability and loss of work in developed countries. Many migraine attacks are seen as a type of "migraine without aura". Other conditions accompanying the headache of migraine patients without aura; nausea, vomiting, sensitivity to light, sound and smell. Migraine patients with aura, on the other hand, may experience "aura" attacks ranging from 5 minutes to 60 minutes before the headache attacks begin. Increased sleep quality Decrease in motor symptoms such as tremors, muscle rigidity, and slowness Relief of complaints related to the autonomic system, such as constipation Improvement in symptoms of depression and anxiety Increase in overall quality of life Reducing dependence on medications or stabilizing the dose Marano et al. (2022) examined the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with Parkinson's disease and reported significant improvements in walking performance and reaction time. In this pilot study conducted with 12 patients, statistically significant improvements were observed in key indicators such as stride length, gait speed, and sway amplitude following taVNS application. The findings suggest that taVNS has the potential to support motor function in patients with Parkinson's disease. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us Contact us

tVNS PARKINSON EXPERIENCE Barry Hanner is a famous Baritone opera singer. He has been using the tVNS device for Parkinson's disease for about two years. Before tVNS, he was suffering from disturbance of equilibrium. He uses it four hours a day at least five times a week. He says that the biggest effect of tVNS is eliminating the disturbance of equilibrium. " tVNS was recommended to help me with my Parkinson's disease symptoms. I use it at least 5 times a week. I realized that the tVNS device has eliminated the balance disorder caused by Parkinson's disease.The device's biggest advantage is providing such a recovery without the requirement for any surgical intervention and without being exposed to the side effects of drugs. I have been using tVNS device for over 2 years and will continue to use it." Barry Hanner. We are working for a better life...

The "tVNS Special Issue", has been published in the "Journal Autonomic Neuroscience", the official journal of the International Society for Autonomic Neuroscience, published by Elsevier. We are proud to design the future of neuroscience and to be the pioneer of the medical technologies. Below are the titles of the articles in the journal. Link is below: 1. tVNS in the treatment of drug-resistant epilepsy 2. Cardiovascular responses to low-level transcutaneous vagus nerve stimulation 3. Electrical vagus nerve stimulation as a prophylaxis for SIRS and postoperative ileus 4. tVNS as a potential therapeutic application for neurodegenerative disorders – A focus on dysautonomia in Parkinson's disease 5. tVNS in the management of headache and pain 6. Brain plasticity and vagus nerve stimulation 7. tVNS for the treatment of postural tachycardia syndrome 8. Functional anatomy of the vagus system – Emphasis on the somato-visceral interface 9. Effects of tVNS on cardiovascular autonomic control in health and disease 10. tVNS and heart rate variability: Analysis of parameters and targets 11. Current challenges in reliably targeting the noradrenergic locus coeruleus using transcutaneous auricular vagus nerve stimulation (taVNS) 12. The LC-NE system as a potential target for neuromodulation to ameliorate non-motor symptoms in Parkinson's disease 13. Vagus nerve afferent stimulation: Projection into the brain, reflexive physiological, perceptual, and behavioral responses, and clinical relevance 14. Transcutaneous vagus nerve stimulation (tVNS) in stroke: the evidence, challenges and future directions 15. t-VNS to treat disorders of behaviour in Prader-Willi Syndrome and in people with other neurodevelopmental conditions 16. Technical aspects and future approaches in transcutaneous vagus nerve stimulation (tVNS) 17. A two-week course of transcutaneous vagal nerve stimulation improves global sleep: Findings from a randomised trial in community-dwelling adults https://www.sciencedirect.com/journal/autonomic-neuroscience/special-issue/10DBND1B8HC

tVNS Nemos, that has improved the quality of life , in more than 3000 patients with epilepsy in the world since 2012, was has been applied to the first pediatric resistant epilepsy patient in Turkey last week. tVNS Nemos, which is the size of a mobile phone, stimulates the ear branch of the vagus nerve with the help of a special electrode headset, reduce the frequency and severity of epilepsy seizures by providing vagus nerve stimulation without the need for any invasive intervention and placement of a device in the body as a result of a total of 4 hours of sessions applied every day. As tVNS Turkey, we aim to reach patients who are suitable for tVNS vagus stimulation therapy and to increase the quality of life of our epilepsy patients.