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tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır EPILEPSY Breakthrough Technologies for Life What is Epilepsy? Epileptic seizure (or seizure) is a clinical condition that occurs when the normal activity of the brain is disrupted as a result of temporary abnormal electrical activity in nerve cells. Epilepsy, also known as "Sara Disease" among the people, manifests itself with epileptic seizures. Epilepsy is a chronic disease. It develops in people who have brain damage during or after birth for any reason. It is a disease seen in 1% of the population in the world and in our country, and about 70% of these patients can be treated with epilepsy drugs called antiepileptic. More than 30 percent of all epileptic patients continue to have seizures despite taking appropriate medications (anticonvulsants) for epileptic seizures, a condition called refractory epilepsy. Several treatment options are available for patients in this condition. Epilepsi, beyin hücrelerinde anormal elektriksel aktivitelerin tekrarlayan nöbetlere yol açtığı kronik bir merkezi sinir sistemi hastalığıdır. Nöbetler; bilinç kaybı, kasılmalar, duyu değişiklikleri veya davranışsal anormallikler şeklinde kendini gösterebilir. Dünya genelinde yaklaşık 50 milyon kişi epilepsi ile yaşamaktadır ve bu sayı epilepsiyi en yaygın nörolojik bozukluklardan biri haline getirmektedir. Epilepsinin tedavisinde genellikle antiepileptik ilaçlar (AEİ) birinci basamak olarak kullanılır. Ancak, epilepsi hastalarının yaklaşık %30’u bu tedavilere yeterli yanıt vermez. Bu grup “ilaca dirençli epilepsi (İDE)” olarak tanımlanır. İDE hastaları için alternatif tedavi yöntemleri büyük önem taşımaktadır. Epilepside Neden Yeni Yaklaşımlar Gerekli? What is Epilepsy? Epileptic seizure (or seizure) is a clinical condition that occurs when the normal activity of the brain is disrupted as a result of temporary abnormal electrical activity in nerve cells. Epilepsy, also known as "Sara Disease" among the people, manifests itself with epileptic seizures. Epilepsy is a chronic disease. It develops in people who have brain damage during or after birth for any reason. It is a disease seen in 1% of the population in the world and in our country, and about 70% of these patients can be treated with epilepsy drugs called antiepileptic. More than 30 percent of all epileptic patients continue to have seizures despite taking appropriate medications (anticonvulsants) for epileptic seizures, a condition called refractory epilepsy. Several treatment options are available for patients in this condition. İlaca direnç: Hastaların yaklaşık %30’u ilaçlarla yeterli nöbet kontrolü sağlayamaz. Yan etkiler: Uyuşukluk, konsantrasyon bozukluğu, kilo artışı, ruh hali değişiklikleri gibi yan etkiler yaşam kalitesini olumsuz etkileyebilir. Uzun süreli kullanım zorunluluğu: İlaçlar genellikle hayat boyu kullanılır ve ani kesilmesi nöbetlerin artmasına neden olabilir. What is Epilepsy? Epileptic seizure (or seizure) is a clinical condition that occurs when the normal activity of the brain is disrupted as a result of temporary abnormal electrical activity in nerve cells. Epilepsy, also known as "Sara Disease" among the people, manifests itself with epileptic seizures. Epilepsy is a chronic disease. It develops in people who have brain damage during or after birth for any reason. It is a disease seen in 1% of the population in the world and in our country, and about 70% of these patients can be treated with epilepsy drugs called antiepileptic. More than 30 percent of all epileptic patients continue to have seizures despite taking appropriate medications (anticonvulsants) for epileptic seizures, a condition called refractory epilepsy. Several treatment options are available for patients in this condition. Yüksek risk: Ameliyat, kanama, enfeksiyon ve nörolojik hasar gibi ciddi komplikasyon riski taşır. Uygunluk sınırlı: Tüm hastalar cerrahi için uygun değildir; özellikle nöbet odaklarının belirlenemediği ya da yaygın olduğu durumlarda ameliyat yapılamaz. Uzun iyileşme süreci: Ameliyat sonrası iyileşme, yaşam kalitesinde geçici azalma yaşanabilir. What is Epilepsy? Epileptic seizure (or seizure) is a clinical condition that occurs when the normal activity of the brain is disrupted as a result of temporary abnormal electrical activity in nerve cells. Epilepsy, also known as "Sara Disease" among the people, manifests itself with epileptic seizures. Epilepsy is a chronic disease. It develops in people who have brain damage during or after birth for any reason. It is a disease seen in 1% of the population in the world and in our country, and about 70% of these patients can be treated with epilepsy drugs called antiepileptic. More than 30 percent of all epileptic patients continue to have seizures despite taking appropriate medications (anticonvulsants) for epileptic seizures, a condition called refractory epilepsy. Several treatment options are available for patients in this condition. İnvaziv prosedür: Cihaz, boyun bölgesine cerrahi ile implant edilir, ameliyat riskleri taşır. Kalıcı implant: Cihaz çıkarılması ya da değiştirilmesi için tekrar cerrahi operasyon gerekir. Yan etkiler: Ses kısıklığı, boğazda rahatsızlık, nefes darlığı gibi yan etkiler görülebilir. Tedavi : İmplantta yapılacak her akım değişikliği hastane ziyareti gerektirir ve bir kaç yılda bir, pil ameliyatla yenilenir. What is Epilepsy? Epileptic seizure (or seizure) is a clinical condition that occurs when the normal activity of the brain is disrupted as a result of temporary abnormal electrical activity in nerve cells. Epilepsy, also known as "Sara Disease" among the people, manifests itself with epileptic seizures. Epilepsy is a chronic disease. It develops in people who have brain damage during or after birth for any reason. It is a disease seen in 1% of the population in the world and in our country, and about 70% of these patients can be treated with epilepsy drugs called antiepileptic. More than 30 percent of all epileptic patients continue to have seizures despite taking appropriate medications (anticonvulsants) for epileptic seizures, a condition called refractory epilepsy. Several treatment options are available for patients in this condition. Epilepsi tedavisinde genellikle ilk seçenek antiepileptik ilaçlardır (AEİ). Bu ilaçlar, birçok hasta için nöbetlerin kontrol altına alınmasını sağlar. Ancak uzun süreli ilaç kullanımı ciddi yan etkilere sebep olur. Ayrıca epilepsi hastalarının yaklaşık %30’unda ilaçlara rağmen nöbetler devam eder. Bu durum, “ilaca dirençli epilepsi (İDE)” olarak adlandırılır ve ciddi bir klinik sorun teşkil eder. İDE hastaları için ikinci basamak tedavi olarak cerrahi yöntemler veya invaziv vagus sinir stimülasyonu (VNS) önerilebilmektedir. Ancak bu seçenekler her hasta için uygun değildir. Bazı hastalar: Cerrahi müdahaleye tıbbi olarak uygun değildir Ameliyatla ilgili risklerden endişe duyar Kalıcı implant istemez Alternatif ve daha az yan etkili çözümler arar Bu nedenle, invaziv olmayan, evde uygulanabilir, bireyselleştirilebilir tedavi yaklaşımlarına ihtiyaç giderek artmaktadır. tVNS® gibi non-invaziv vagus sinir stimülasyonu cihazları, bu ihtiyaca yönelik geliştirilen bilimsel tabanlı seçenekler arasında yeni bir çağa öncülük etmektedir. tVNS®’nin Epilepsi Tedavisine Sağladığı Faydalar İnvaziv Cerrahiye Alternatif Ameliyat gerektirmeden uygulanabilir. Tedavi takibi mobil uygulama ile uzaktan yapılabilir. Evde Uygulama İmkanı Hasta tarafından günlük olarak, kendi yaşam ortamında kolaylıkla kullanılabilir. Onaylı ve Güvenli Avrupa Birliği Tıbbi Cihaz Regülasyonu kapsamında Sınıf IIa medikal cihaz onayına sahiptir ve TC Sağlık Bakanlığı onaylıdır. İlaç Tedavisini Tamamlayıcı AEİ tedavisinin yanında kullanılabilir; tedavinin kesilmesine gerek yoktur. Bireyselleştirilmiş Terapi Uyarım parametreleri hastaya özel olarak ayarlanabilir. What is Epilepsy? Epileptic seizure (or seizure) is a clinical condition that occurs when the normal activity of the brain is disrupted as a result of temporary abnormal electrical activity in nerve cells. Epilepsy, also known as "Sara Disease" among the people, manifests itself with epileptic seizures. Epilepsy is a chronic disease. It develops in people who have brain damage during or after birth for any reason. It is a disease seen in 1% of the population in the world and in our country, and about 70% of these patients can be treated with epilepsy drugs called antiepileptic. More than 30 percent of all epileptic patients continue to have seizures despite taking appropriate medications (anticonvulsants) for epileptic seizures, a condition called refractory epilepsy. Several treatment options are available for patients in this condition. İlaçlarla yeterli kontrol sağlanamayan hastalar (İDE) İlaçların uzun dönemli yan etkilerinden kaçınmak için ilaç kullanımını azaltmak isteyen hastalar Cerrahi müdahaleye uygun olmayan bireyler Vagus sinir stimülasyonunun nöbet dışında ruh hali, zihin ve motor gelişimi etkilerini deneyimlemek isteyen hastalar Non-invaziv ve evde uygulanabilir bir terapi arayan hastalar ve aileleri WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır AUTISM Groundbreaking Technologies For life What is Autism? Autism is a congenital, neurological disease, and it is a behavioral and verbal disorder that negatively affects a person's quality of life. There are symptoms such as inability to make eye contact, repetitive behaviors, and difficulty in social activities. In addition, individuals with autism are sensitive to sensory stimuli such as lights and sounds. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Autism Asperger's Syndrome: Asperger's Syndrome is the mildest type of autism. The person with this syndrome may be very intelligent and excel at work. However, they have difficulty in socializing. Classical Au tis m: Classical autism, also known as autism, shows symptoms such as communication disorder, restrictive and repetitive behaviors with severe socialization and communication problems. Atypical Autis m: Children who have autism symptoms but do not meet the criteria enough to diagnose the disease are called atypical autism. Speech and communication disorders of individuals with atypical autism can be corrected with early diagnosis and correct treatment methods. Treatment Options for Autism Özel Eğitim Tedavisi Özel eğitim tedavisi otizmli bireylerin sosyal hayata adaptasyonunu kolaylaştırır. Daha fazla bilgi Fizik Tedavi Bireyin motor becerilerini geliştirmek için fizik tedavi uygulanır. Daha fazla bilgi Özel Diyetler Otizmin toplumda görülme sıklığı artıkça, beslemenin önemi de artmaktadır. Daha fazla bilgi Transkutanöz Vagus Sinir Stimulasyonu (tVNS) tVNS® cihazı dünyada "otizm" için onaylanmış tek medikal vagus uyarım cihazıdır. Daha fazla bilgi Rett Syndrome: It is a disease as a type of autism that occurs in infancy. The incidence in girls is higher than in boys. It has symptoms such as problems with crawling or walking, decreased eye contact. WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Crohn's Disease Groundbreaking Technologies for Life What is Crohn's Disease ? Crohn's disease is a type of inflammatory bowel disease that causes inflammation of the gastrointestinal tract from the mouth to the anus. This inflammation can be attached to one or more parts of the digestive system, but it is usually seen in the ileum, which is the last part of the small intestine, and in the beginning of the large intestine. Crohn's disease can cause inflammation in your digestive tract, leading to abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition. Growth-development retardation in children may be signs of Crohn's disease. Extra-intestinal diseases are also observed in a quarter of Crohn's patients. These mostly occur in the skin, joints, eyes, liver and biliary tract, kidney and urinary tract, vascular heart and lungs. Crohn's Disease Symptoms Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Insomnia Diagnostic Methods Crohn's Disease Causes Immune system: It is possible for a virus or bacteria to trigger Crohn's disease; however, scientists have yet to identify such a trigger. When your immune system tries to fight off the invading microorganism, an abnormal immune response can cause the immune system to attack cells in the digestive tract as well. Heredity: Crohn's disease is more common in people with a family history of the same disease, so genes may play a role in the occurrence of the disease. Crohn's Disease Diagnostic Methods Blood analysis stool analysis Stomach, small and large intestine films Colonoscopy and endoscopy CT and MRI images Crohn's disease can occur at any age, but it usually occurs when the disease is young. Most people who develop Crohn's disease are diagnosed before they reach the age of about 30. You are at higher risk for the disease if you have a first-degree relative with the disease, such as a parent, sibling, or child. About 1 in 5 people with Crohn's disease have a family member with the disease. Facts About Crohn's Disease Treatment Options for Crohn's Disease İlaç Tedavisi Steroid ilaçlar: Sindirim sistemindeki iltihabı azaltmaya yönelik ilaçlardır. Daha fazla bilgi Cerrahi Tedavi Crohn hastalarının çoğu cerrahi tedaviye gerek duyabilmektedir. Daha fazla bilgi Crohn Hastalığı Diyeti Genel olarak hastaya yüksek enerji içeren, bol protein, az posalı, az yağlı, vitamin ve minerallerden zengin diyet uygulanır. Daha fazla bilgi Transkutanöz Vagus Sinir Stimulasyonu (tVNS) tVNS-L ® bağırsaktaki enflamasyonun azaltılması, bağırsağın görevini daha sağlıklı yapabilmesine olanak tanır. Daha fazla bilgi Contact us

tVNS PARKINSON EXPERIENCE Barry Hanner is a famous Baritone opera singer. He has been using the tVNS device for Parkinson's disease for about two years. Before tVNS, he was suffering from disturbance of equilibrium. He uses it four hours a day at least five times a week. He says that the biggest effect of tVNS is eliminating the disturbance of equilibrium. " tVNS was recommended to help me with my Parkinson's disease symptoms. I use it at least 5 times a week. I realized that the tVNS device has eliminated the balance disorder caused by Parkinson's disease.The device's biggest advantage is providing such a recovery without the requirement for any surgical intervention and without being exposed to the side effects of drugs. I have been using tVNS device for over 2 years and will continue to use it." Barry Hanner. We are working for a better life...

The "tVNS Special Issue", has been published in the "Journal Autonomic Neuroscience", the official journal of the International Society for Autonomic Neuroscience, published by Elsevier. We are proud to design the future of neuroscience and to be the pioneer of the medical technologies. Below are the titles of the articles in the journal. Link is below: 1. tVNS in the treatment of drug-resistant epilepsy 2. Cardiovascular responses to low-level transcutaneous vagus nerve stimulation 3. Electrical vagus nerve stimulation as a prophylaxis for SIRS and postoperative ileus 4. tVNS as a potential therapeutic application for neurodegenerative disorders – A focus on dysautonomia in Parkinson's disease 5. tVNS in the management of headache and pain 6. Brain plasticity and vagus nerve stimulation 7. tVNS for the treatment of postural tachycardia syndrome 8. Functional anatomy of the vagus system – Emphasis on the somato-visceral interface 9. Effects of tVNS on cardiovascular autonomic control in health and disease 10. tVNS and heart rate variability: Analysis of parameters and targets 11. Current challenges in reliably targeting the noradrenergic locus coeruleus using transcutaneous auricular vagus nerve stimulation (taVNS) 12. The LC-NE system as a potential target for neuromodulation to ameliorate non-motor symptoms in Parkinson's disease 13. Vagus nerve afferent stimulation: Projection into the brain, reflexive physiological, perceptual, and behavioral responses, and clinical relevance 14. Transcutaneous vagus nerve stimulation (tVNS) in stroke: the evidence, challenges and future directions 15. t-VNS to treat disorders of behaviour in Prader-Willi Syndrome and in people with other neurodevelopmental conditions 16. Technical aspects and future approaches in transcutaneous vagus nerve stimulation (tVNS) 17. A two-week course of transcutaneous vagal nerve stimulation improves global sleep: Findings from a randomised trial in community-dwelling adults https://www.sciencedirect.com/journal/autonomic-neuroscience/special-issue/10DBND1B8HC

tVNS Nemos, that has improved the quality of life , in more than 3000 patients with epilepsy in the world since 2012, was has been applied to the first pediatric resistant epilepsy patient in Turkey last week. tVNS Nemos, which is the size of a mobile phone, stimulates the ear branch of the vagus nerve with the help of a special electrode headset, reduce the frequency and severity of epilepsy seizures by providing vagus nerve stimulation without the need for any invasive intervention and placement of a device in the body as a result of a total of 4 hours of sessions applied every day. As tVNS Turkey, we aim to reach patients who are suitable for tVNS vagus stimulation therapy and to increase the quality of life of our epilepsy patients.