Search Results

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Epilepsy Symptoms, Causes and Diagnostic Methods Epilepsy Symptoms Since epilepsy is a dysfunction that occurs in the brain, the symptoms of epilepsy may vary depending on the function of the affected area of the brain. We can list some symptoms of the disease as follows: Sudden contractions in the body Loss of consciousness Very rapid nodding Uncontrollable shaking in arms and legs wink quickly Looking at a fixed point Being unable to react to sounds or speech for a short time Fear, anxiety or deja vu etc. psychological symptoms Epilepsy Causes Epilepsy is a condition that can have many causes and can occur at any age. It usually starts in childhood. Any disease that affects the brain can cause epileptic seizures. Infections in the womb Birth traumas, lack of oxygen during birth Head injury Genetic and metabolic diseases High fever diseases, Excessive low blood sugar, Intracranial tumors, Brain inflammations. Paralysis Brain tumor Developmental brain malformations Brain infections such as meningitis can lead to epilepsy, Vascular abnormalities, especially in the brain vessels of individuals in the advanced age group, Some epilepsies occur as a result of an electrical activity spreading from this region as a result of disruption in a certain region of the brain. Epilepsies resulting from brain tumors and traumas can be given as examples for this situation. In some types of epilepsy, there is no damage in a single area. An epileptic seizure begins suddenly in the entire brain. Childhood-onset epilepsies are usually of this type. Types of epilepsy also differ from person to person, and this situation also affects the causes and causes of epilepsy. Because not every epilepsy person shows the same symptoms. Epilepsy Diagnostic Methods Imaging methods are one of the primary methods used in the diagnosis of epilepsy. (EEG), (MR) and computed tomography are among the most commonly used imaging methods. EEG, which indicates the electrical activity of the brain, is especially important in the diagnosis of epilepsy. Thanks to EEG, regions of the brain with uncontrolled bioelectrical activity are detected. Whether there is any structural problem that causes seizures is understood by MRI and tomography. If required by specialist physicians, blood and urine tests are also performed. For the diagnosis of epilepsy, the patient's medical history, frequency and severity of seizures, and symptoms are among the points that physicians pay attention to. Sometimes, extreme stress, fatigue, emotional and hormonal changes can also cause seizures. In this sense, not every seizure indicates epilepsy. Physicians can diagnose after listening to patients' stories. People with epilepsy About 50 million people in the world have epilepsy, making epilepsy one of the most common neurological diseases worldwide. It can be seen at any age, although it is more common in childhood and over 65 years of age. Epilepsy can occur in both sexes at any age and in any geographic area. Most people are likely to have an epileptic seizure once in their lifetime. People with more than one epileptic seizure are considered epileptic and should be treated with appropriate medications. In Turkey, 7 out of every 1000 people suffer from epilepsy. Contact us

tVNS Vagus Stimülasyon Cihazları Bilgi Talep Formu Home Page

2012 yılından bu yana epilepsi, migren ve depresyona karşı etkinliğini test edebilmek için, transkutanöz vagus siniri uyarımı, tVNS E ve tVNS M üzerine dünyanın çeşitli üniversite ve araştırma klinklerinde çok sayıda çalışma ve araştırmalar yapılmıştır. Science for a better life We Design the Treatments of the Future Clinical Studies Vagus nerve stimulation (VNS) has become a standard therapeutic option for patients with treatment resistant epilepsy and depression and globally is gaining increasing acceptance. Based on the positive experiences with implantable systems, transcutaneous vagus nerve stimulation (tVNS) was first introduced 20 years ago. The field of tVNS is rapidly expanding since the external stimulation is non-invasive and thus avoids numerous side-effects of invasive VNS; tVNS is easily accessible, less expensive and therefore more readily available than conventional VNS. However, transcutaneous stimulation of the outer ear poses new questions regarding the optimal stimulation site and stimulus parameters as well as the physiology and pathways of transcutaneous auricular VNS. Moreover, therapeutic options and realistically reachable goals of tVNS need to be explored. During the last 20 years, basic and clinical research has unraveled many of these questions and augmented our understanding of tVNS pathways and physiologic effects. The number of publications increased exponentially within the last three years and continues to grow rapidly. Many questions have been addressed and therapeutic indications beyond the treatment of drug-resistant epilepsy and depression are steadily expanding and continue to be explored. Redgrave 2018: Safety and Tolerability of tvNS Wrede Case Study 2019 : Sustained seizure freedom with transcutaneous vagal nerve stimulation in drug-resistant epilepsy caused by subcortical band heterotopias Yakunina 2016: Optimization of Transcutaneous Vagus Nerve Stimulation Using Functional MRI Ellrich 2019: Transcutaneous Auricular Vagus Nerve Stimulation Study Bauer 2015: Transcutaneous Vagus Nerve Stimulation (tVNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial Straube 2015: Treatment of chronic migraine with Transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial tVNS JOURNAL The "tVNS Special Issue", which includes 17 studies on our tVNS devices, has been published in the "Journal Autonomic Neuroscience" by Elsevier, the official journal of the International Society for Autonomic Neuroscience. Journal Please contact us if you would like to receive more information about the results of many clinical studies and ongoing studies, apart from the studies given as examples above. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Groundbreaking Technologies For life Potential Therapeutic Benefits Reduction of Anxiety and Hyperarousal Improvement of Social Engagement Enhancement of Attention and Cognitive Flexibility Regulation and Improvement of Sleep Patterns Support for Language Development While 1 in every 150 children was diagnosed with autism in the early 2000s, this rate increased to 1 in every 36 children by 2025 . Mechanism of Action of tVNS in Autism The Vagus Nerve and Its Brain Connections tVNS works by stimulating the auricular vagus nerve, located in the ear (specifically in the cymba concha region), through the skin surface. This nerve carries information directly to the brainstem and from there to regions such as the limbic system and prefrontal cortex. 🔹 Nucleus Tractus Solitarius (NTS) → This center in the brainstem receives vagus signals. 🔹 Signals from NTS: Amygdala → Emotional regulation Hippocampus → Learning and memory Prefrontal Cortex → Social decision making, planning, attention What You Wonder About tVNS in Autism tVNS®, kaygıyı azaltıp konsantrasyonu arttırarak, beyni öğrenmeye daha açık bir biyolojik duruma getirebilir. Bu gelişmiş dikkat ve öğrenme potansiyeli, bireylerin yeni beceriler kazanımını hızlandırabilir. By reducing anxiety and increasing concentration, tVNS® can put the brain in a more receptive biological state for learning. This improved attention and learning potential can accelerate individuals' acquisition of new skills. tVNS®, kaygıyı azaltıp konsantrasyonu arttırarak, beyni öğrenmeye daha açık bir biyolojik duruma getirebilir. Bu gelişmiş dikkat ve öğrenme potansiyeli, bireylerin yeni beceriler kazanımını hızlandırabilir. By reducing anxiety and increasing concentration, tVNS® can put the brain in a more receptive biological state for learning. This improved attention and learning potential can accelerate individuals' acquisition of new skills. Potential Benefits Targeted in Autism with tVNS® Increased capacity for social interaction Improving emotional regulation Increased attention and focus Decrease in irritability and repetitive behaviors Better quality and regular sleep Reducing anxiety and stress response In their study published in the journal Frontiers in Neuroscience, He and colleagues (2021) examined the effects of tVNS on functional connectivity between brain regions in children with autism spectrum disorder (ASD). The study used functional magnetic resonance imaging (fMRI) and observed increased connectivity, particularly in networks associated with social cognition, emotional regulation, and attention. The findings revealed that tVNS strengthened neural communication in children with autism. This supports its potential for improvement in clinical symptoms. The authors emphasize that tVNS, as a non-invasive intervention, could be an important complementary treatment option for neurodevelopmental disorders. The study also highlighted its safe use profile in children. Why Are New Approaches Necessary? Targets specific symptoms: It is used only for behavioral or accompanying symptoms (such as anxiety, hyperactivity, sleep disorders), not for the root cause of autism. Side effects: Appetite changes, sleep problems, weight gain, hormonal and neurological side effects may occur. Long-term use may be necessary: Dependence and long-term effects from the drug may be a concern. Security and Ease of Application Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. What is Autism? Autism is a congenital, neurological disease, and it is a behavioral and verbal disorder that negatively affects a person's quality of life. There are symptoms such as inability to make eye contact, repetitive behaviors, and difficulty in social activities. In addition, individuals with autism are sensitive to sensory stimuli such as lights and sounds. WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us Contact us

tVNS, Vagus Nerve Stimulation for Depression Depression Symptoms, Causes and Diagnostic Methods Depression Symptoms Constantly feeling sad Loss of interest and pleasure in daily activities Appetite changes: Overeating and loss of appetite Difficulty falling asleep, waking up frequently, or sleeping excessively Constantly feeling tired Slowness in speech and movements Feeling worthless and guilty Loss of concentration, difficulty making decisions Suicidal tendencies Kokkun emotion Life-threatening thoughts Causes of Depression The causes of depression may vary from person to person, but in general, it is possible to collect them under a few headings. Depression, which is seen in almost every age group due to different reasons, is a psychological disorder that manifests itself with different symptoms. In general, it is known that stress, anxiety, current problems and many other factors can cause depression. Depression Diagnostic Methods Diagnosis of depression usually begins with a physical examination. During the physical examination, the doctor may ask questions about the individual's health. In some cases, depression may be linked to an underlying physical health condition. Laboratory tests may then be required. The doctor may do a blood test called a complete blood count or test the thyroid gland to make sure it's working properly. The next step is a psychiatric evaluation. The mental health professional asks questions to learn about their symptoms, thoughts, feelings, and behavior patterns. The individual may be asked to complete a questionnaire to help answer these questions. Who Has Depression visible Depression is a mood disorder that can be seen in almost every age group. It is stated that depression can be seen in children and adolescents as well as in the elderly. Studies show that the prevalence of depression in Turkey is 2.3% in men and 5.4% in women. Depression is more common in women, on the other hand, it is defined as more areas where men can express themselves differently. According to the data, one out of every six people will experience depression at least once in their lifetime. Therefore, it would not be wrong to say that depression is one of the most common psychological disorders. Although its effects are not as large as many other psychological disorders, depression is a condition that should be taken seriously because it can cause different psychological disorders. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır INSOMNIA (SLEEP DISORDER) Groundbreaking Technologies for Life What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Insomnia Acute insomnia : It refers to the short-term appearance of insomnia. Acute insomnia usually occurs after a stressful day or on days when mental tension is high. Our body clock has a har d time showing when it's time to rest on such difficult days. This irregularity, which usually lasts for 1 to 2 days, continues until we feel better. There are signs of acute insomnia that can last up to 4 weeks. Chronic insomnia: A sleep disorder that lasts for 1 month or more is called chronic insomnia. A large proportion of 10-15% of adults suffer from chronic in somnia. Compared to acute insomnia, chronic insomnia requires medical attention. The main cause of this type of disorder is usually the presence of major depression. Hypersomnia: characterized by excessive sleepiness and excessive daytime sleep requirements. It is less common than insomnia. Narcolepsy : Includes excessive daytime sleepiness and abnormal findings in daily REM sleep for at least 3 months. Narcolepsy is an abnormality in the sleep mechanism, especially in the REM mechanism. Treatment Options for Insomnia Sleep Techniques The flow of air in and out of the lungs during breathing Blood oxygen levels. Body position. More information CPAP Titration (Mask Therapy) In some cases of severe depression, hospitalization is necessary. This may be necessary if the individual is unable to care for themselves properly or is in danger of harming themselves or others. More information Polysomnography In other words, a sleep test is a procedure that uses devices to record sleep throughout the night to determine the quality of sleep and identify the cause of sleep disturbances. More information Transcutaneous Vagus Nerve Stimulation (tVNS) The vagus nerve facilitates communication between the gut and the brain. When you're unhappy, the vagus nerve senses that something is wrong and activates the sympathetic nervous system, a key component of the digestive system, which then releases cortisol. More information WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır MIGRAINE Groundbreaking Technologies for Life What is Migraine? It is a neurological disorder that causes a throbbing, severe headache, often felt intensely on one side of the head. The distinctive features of migraine that distinguish it from other headaches include nausea and vomiting, and sensitivity to sound and light. The pain is so severe that it interferes with the completion of daily activities and leads to limitation. Migraine attacks take the first place among the most important causes of disability and loss of work in developed countries. Many migraine attacks are seen as a type of "migraine without aura". Other conditions accompanying the headache of migraine patients without aura; nausea, vomiting, sensitivity to light, sound and smell. Migraine patients with aura, on the other hand, may experience "aura" attacks ranging from 5 minutes to 60 minutes before the headache attacks begin. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine Attacks Headache, which progresses in attacks in migraine, occurs more than fifteen days a month within three months, each pain lasts at least 4 hours and if migraine-type pain is experienced at least 8 days a month, this is defined as "chronic migraine". In Migraine Treatment, treatment is planned depending on the frequency and severity of the person's headaches and other accompanying medical conditions. The desire of the patients to sleep in a room without light or the feeling of vomiting helps to alleviate or end the migraine attack. These attacks may differ in individuals, for example; Migraine attacks that occur intermittently are called “episodic migraine”. If the attacks occur fifteen days or more per month in the last three months, it is called "chronic migraine". Chronic migraine can often be accompanied by anxiety disorders, depression and sleep problems. Chronic migraine can lead to serious health problems if left untreated. Treatment Options for Migraine Akupunktur Tedavisi One of the most commonly used treatment methods for migraine in Western countries is acupuncture. More information Migraine Surgery It can be summarized as an intervention on the nerve branches located in the forehead, temples, neck and nape of the neck of the areas of the brain associated with migraine, and the vessels and muscles around these nerve branches. More information Botulinum Toxic Therapy Another treatment method for chronic migraine patients is botulinum toxin treatment, which has been used since 2010. More information Transcutaneous Vagus Nerve Stimulation (tVNS) Migraine is a chronic disease that significantly reduces quality of life. In addition to treatment options such as vaccinations, medications, and surgery, TVNS offers a non-invasive treatment option. More information Contact us WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE

PATIENT DECLARATION FORM CLINICAL DIAGNOSIS & HEALTH CONDITIONS

Transkutanöz Vagus Sinir Stimülasyonu (tVNS), vagus sinirine bir kulakluk yardımıyla elektriksel uyarılar verilmesini içeren tıbbi bir tedavidir . Dirençli epilepsi, kronik migren ve ilaca dirençli depresyon için etkili bir tedavi olarak kullanılır. What is Vagus Nerve? Discover The vagus nerve is the longest cranial nerve in the body. It comes from the Latin word, vagus, for “wandering.” That’s because it wanders throughout your body, with wide distribution connecting the brainstem to the body. Only mammals have this nerve. The vagus nerve serves as the body's superhighway, carrying information between the brain and the internal organs and controlling the body's response in times of rest and relaxation. It helps the immune system and inflammation response to disease. It has four main functions: sensory, special sensory, motor and parasympathetic. The vagus nerve also manages fears and sends information from the gut to the brain, which is linked to dealing with stress, anxiety, and fear–hence the saying, ‘gut feeling'. Historical Development of Vagus Nerve Stimulation Epilepsy has existed in human history with the first record found in a Babylonian text written 4000 years ago, and humanity has sought a cure for this disease for centuries. With the emergence of neurology in the 19th century, the mechanism between the nervous system and epilepsy was tried to be solved and the first vagus nerve stimulation was tried by a New York neurologist in the early 1880s. Over the next 100 years, the effects of vagus nerve stimulation were first investigated in animal experiments, then in humans, and in 1996, the vagus nerve was surgically implanted into the body and become an invasive stimulation option. At the beginning of the 2000s, for eliminating the side effects of invasive VNS, scientists tried to find out ways to stimulate the vagus nerve non-invasively, and by 2010 these studies were concluded successfully. Our first generation device, Nemos, was approved in 2010 for the treatment of epilepsy and depression, and Vitos in 2012 for the treatment of pain and migraine, as the first medically approved non-invasive vagus nerve stimulation treatment in the world. Our 2nd generation device, tVNS-L, has been approved in 2021, and has become a treatment option used in many neurodegenerative diseases. Vagus Nerve Stimulation Effect Overview Regulation of neurotransmitter release Increase in parasympathetic activity Increase in brain neuroplasticity Reducing inflammation Increasing the secretion of serotonin and increasing the mood What Are the Effects of Vagus Nerve Stimulation? Stimulation of the vagus triggers regulatory mechanisms in the nervous, immune, autonomic, endocrine, cardiorespiratory, and gastrointestinal systems. Clinical studies on the vagus nerve have shown that the activity in this nerve is closely related to epilepsy, depression, migraine, headache, inflammatory bowel disease, Alzheimer's, arthritis and many other common disorders by activating the parasympathetic nervous system in the brain and increasing the secretion of neurotransmitters in special regions of the brain. shows. Vagus nerve stimulation therapies are approved by FDA in the USA and CE in Europe for use in treatments such as mood improvement, pain relief, sleep improvement, memory enhancement and anxiety reduction. Research continues on the effects of neuroplasticity as well as its cardiac and inflammatory properties. Contact us