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tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır MIGRAINE Groundbreaking Technologies for Life What is Migraine? It is a neurological disorder that causes a throbbing, severe headache, often felt intensely on one side of the head. The distinctive features of migraine that distinguish it from other headaches include nausea and vomiting, and sensitivity to sound and light. The pain is so severe that it interferes with the completion of daily activities and leads to limitation. Migraine attacks take the first place among the most important causes of disability and loss of work in developed countries. Many migraine attacks are seen as a type of "migraine without aura". Other conditions accompanying the headache of migraine patients without aura; nausea, vomiting, sensitivity to light, sound and smell. Migraine patients with aura, on the other hand, may experience "aura" attacks ranging from 5 minutes to 60 minutes before the headache attacks begin. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine Attacks Headache, which progresses in attacks in migraine, occurs more than fifteen days a month within three months, each pain lasts at least 4 hours and if migraine-type pain is experienced at least 8 days a month, this is defined as "chronic migraine". In Migraine Treatment, treatment is planned depending on the frequency and severity of the person's headaches and other accompanying medical conditions. The desire of the patients to sleep in a room without light or the feeling of vomiting helps to alleviate or end the migraine attack. These attacks may differ in individuals, for example; Migraine attacks that occur intermittently are called “episodic migraine”. If the attacks occur fifteen days or more per month in the last three months, it is called "chronic migraine". Chronic migraine can often be accompanied by anxiety disorders, depression and sleep problems. Chronic migraine can lead to serious health problems if left untreated. Treatment Options for Migraine Akupunktur Tedavisi One of the most commonly used treatment methods for migraine in Western countries is acupuncture. More information Migraine Surgery It can be summarized as an intervention on the nerve branches located in the forehead, temples, neck and nape of the neck of the areas of the brain associated with migraine, and the vessels and muscles around these nerve branches. More information Botulinum Toxic Therapy Another treatment method for chronic migraine patients is botulinum toxin treatment, which has been used since 2010. More information Transcutaneous Vagus Nerve Stimulation (tVNS) Migraine is a chronic disease that significantly reduces quality of life. In addition to treatment options such as vaccinations, medications, and surgery, TVNS offers a non-invasive treatment option. More information Contact us WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE

tVNS® CARE Therapy Tracking tVNS® CARE Therapy Tracking In medical device treatments that can be applied at home without a doctor's supervision, the most important requirement for the success of the treatment is that a protocol specific to the patient's needs is prepared and that the patient is using the device correctly and is monitored by the doctor and a team of experts. The world-unique tVNS Care® Technology is a digital health service that can increase the success rate of treatment by up to 50%*, where a patient-specific program is prepared by referencing the protocols of similar patients in more than 50 countries, and all details of the treatment can be monitored online by our expert teams. tVNS Therapy Devices tVNS Health website tVNS® vagus therapy devices offer a non-surgical neuromodulation treatment option by providing auricular vagus nerve stimulation in difficult-to-treat brain diseases with the help of a smartphone-sized device and a special electrode. With its innovative mobile application, the patient can share all the treatment information with a single click without leaving his home, and reach the necessary follow-up and support. tVNS® stimulates the branch of the vagus nerve in the auricle through the skin with gentle electrical impulses. Signals are passed on to the brain via special nerve fibers: first in the brain stem and then in higher centers. The treatment with tVNS® is applied by patients independently. It has been used by thousands of patients and is a treatment with very few side effects.

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Cognitive Impairment Groundbreaking Technologies for Life What is Cognitive Impairment? The shrinkage caused by the loss of cells in the brain causes various functional disorders. These dysfunctions may manifest as dementia, Alzheimer, and mild cognitive impairment, which are common in people ives. People with cognitive impairment are at high risk for Alzheimer and dementia. When adequate precautions are taken, cognitive impairment may regress, and it is possible for these people to lead a normal life. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Cognitive Disorder Dementia It is the inadequacies experienced in language, skills and orientation, especially forgetfulness. Dementia is a family that includes many different types. There are Alzheimer's, dementia due to chronic cerebrovascular disease, alcoholic dementia, depressive dementia, dementia due to infections, etc. Dementia occurs as a result of general deterioration of the upper level functions of the cerebral cortex, especially over 75 years of age, with advancing age. There are dementias that start with memory impairment such as Alzheimer's disease, as well as behavioral disorders, skill disorders, depression, There are also dementias that start with the symptoms of parkinson's disease and language disorders. It is a progressive disease. Alzheimer It is the most common type of dementia is a neurological disease that causes the destruction of brain cells. The disease, which causes a decrease in thought, memory and behavioral functions, occurs after a long time with advancing age. It may take years for the disease to reach advanced stages. Because it is a progressive disease, Alzheimer's patients experience problems such as inability to perform their daily tasks, forgetfulness and serious confusion. People with memory loss or other possible Alzheimer's symptoms may have trouble recognizing that they have a problem. Treatment Options for Cognitive Disorder There is no drug therapy approved to treat cognitive impairment. Medicines used to treat symptoms of Alzheimer's disease have been tried. Some studies have found that using these drugs for cognitive impairment is helpful, while others have concluded that there is no benefit. It has been noted that the use of other drugs, including NSAIDs, Ginkgo, Biloba and vitamin E, does not provide a great benefit. tVNS Effect Mechanism There are many clinical studies in recent years that cognitive disorders are caused by inflammation in the brain. Although the basic efficacy mechanism of tVNS has not been fully resolved, our new generation devices in 2021 became the first neuromodulation therapy approved for cognitive impairment in the world, due to both its benefits in the treatment of inflammation and the increase in neuroplasticity. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Tinnitus Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Contact Us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır IN EPILEPSY Treatment Without Drugs or Surgery Is Possible Benefits of tVNS® in Epilepsy Treatment Alternative to Invasive Surgery It can be performed without surgery. Treatment can be monitored remotely using a mobile app. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own living environment. Approved and Safe It has Class IIa medical device approval under the European Union Medical Device Regulation and Approved by the Turkish Ministry of Health. Complementary to Drug Therapy It can be used alongside AED treatment; there is no need to discontinue treatment. Individualized Therapy Stimulation parameters can be adjusted individually to the patient. Why tVNS® Therapy? In epilepsy treatment, the first-line option is usually antiepileptic drugs (AEDs). For many patients, these medications help control seizures. However, long-term drug use can cause serious side effects. Moreover, in about 30% of epilepsy patients, seizures persist despite medication. This condition is known as drug-resistant epilepsy (DRE) and represents a major clinical challenge. For DRE patients, second-line treatments may include surgical interventions or invasive vagus nerve stimulation (VNS). Yet, these options are not suitable for every patient. Some patients: Are not medically eligible for surgery Fear the risks associated with surgery Do not want a permanent implant Seek alternative solutions with fewer side effects As a result, there is a growing need for non-invasive, home-based, and personalized treatment approaches. Non-invasive vagus nerve stimulation devices such as tVNS® represent a science-based solution that is pioneering a new era in addressing this unmet need. Epilepsy is a chronic central nervous system disorder in which abnormal electrical activity in brain cells causes recurring seizures. Seizures can manifest as loss of consciousness, convulsions, sensory changes, or behavioral abnormalities. Approximately 50 million people worldwide live with epilepsy, making it one of the most common neurological disorders. Antiepileptic drugs (AEDs) are generally used as the first-line treatment for epilepsy. However, approximately 30% of patients with epilepsy do not respond adequately to these treatments. This group is defined as "drug-resistant epilepsy (DRE)." Alternative treatment methods are of great importance for patients with DRE. Why Are New Approaches Necessary in Epilepsy? Why Are New Approaches Necessary in Epilepsy? Drug resistance: Approximately 30% of patients cannot achieve adequate seizure control with medications. Side effects: Side effects such as drowsiness, loss of concentration, weight gain, and mood swings can negatively impact quality of life. Long-term use is necessary: Medications are usually used for life and sudden discontinuation may cause an increase in seizures. High risk: Surgery carries a risk of serious complications such as bleeding, infection, and neurological damage. Limited suitability: Not all patients are suitable for surgery; surgery cannot be performed, particularly in cases where seizure foci cannot be identified or are widespread. Long recovery process: Post-operative recovery may result in a temporary decrease in quality of life. Why Are New Approaches Necessary in Epilepsy? Why Are New Approaches Necessary in Epilepsy? Invasive procedure: The device is surgically implanted in the neck area, which carries surgical risks. Permanent implant: Re-surgery is required to remove or replace the device. Side effects: Side effects such as hoarseness, throat discomfort, and shortness of breath may occur. Treatment: Every change in the implant current requires a hospital visit, and every few years the battery is replaced surgically. Why Are New Approaches Necessary in Epilepsy? Patients who cannot be adequately controlled with medications (IDE) Patients who want to reduce their medication use to avoid long-term side effects of medications Individuals who are not suitable for surgical intervention Patients who wish to experience the mood, mental, and motor development effects of vagus nerve stimulation other than seizures Patients and families seeking non-invasive, at-home therapy Treatment Stories of tVNS® Patients My 7-year-old son with Dravet syndrome had seizure periods that required intensive care treatments every month. We have been using tVNS for 2 years, and we are happy to have a seizure-free life, obtain mental development, and reduction in autism symptoms. Zeliha KORKMAZ, Kayseri, Erciyes University Prof. Dr. Hakan GüMüŞ WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Cognitive Impairment Symptoms, Causes and Diagnostic Methods Cognitive Disorder Symptoms Forgetfulness Lack of attention Excitement Unrest Speech difficulties Sleep disorder Causes of Cognitive Impairment Although the exact cause of cognitive impairment is not known exactly, the person's predisposition to Alzheimer's and dementia causes this disease. The following situations may also be the cause of cognitive impairment; Thyroid, kidney, or liver problems Depression, anxiety and stress Conditions that affect blood flow in the brain Vitamin B12 deficiency Cognitive Disorder Diagnostic Methods The diagnosis of cognitive disorder is made by neurology and psychiatry specialists. At this stage, it is very important to be accompanied by someone who knows and observes the patient closely. People with Cognitive Disorder The incidence in people over the age of 65 is around 15-20%. People with cognitive impairment are likely to progress to Alzheimer and dementia. However, cognitive impairment may not always be progressive. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır MIGRAINE Groundbreaking Technologies for Life Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. " tVNS treatment provides great support for my balance issues. I can walk about 15 km on the golf course once a week. I still take medication, but I know my balance problems have improved thanks to the tVNS device. "tVNS® is a research-proven, non-invasive treatment option that supports neurological function and can help people with Parkinson's disease stay active, mobile, and engaged in life." Barry H., a Parkinson's patient and tVNS® user, What is Migraine? It is a neurological disorder that causes a throbbing, severe headache, often felt intensely on one side of the head. The distinctive features of migraine that distinguish it from other headaches include nausea and vomiting, and sensitivity to sound and light. The pain is so severe that it interferes with the completion of daily activities and leads to limitation. Migraine attacks take the first place among the most important causes of disability and loss of work in developed countries. Many migraine attacks are seen as a type of "migraine without aura". Other conditions accompanying the headache of migraine patients without aura; nausea, vomiting, sensitivity to light, sound and smell. Migraine patients with aura, on the other hand, may experience "aura" attacks ranging from 5 minutes to 60 minutes before the headache attacks begin. Increased sleep quality Decrease in motor symptoms such as tremors, muscle rigidity, and slowness Relief of complaints related to the autonomic system, such as constipation Improvement in symptoms of depression and anxiety Increase in overall quality of life Reducing dependence on medications or stabilizing the dose Marano et al. (2022) examined the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with Parkinson's disease and reported significant improvements in walking performance and reaction time. In this pilot study conducted with 12 patients, statistically significant improvements were observed in key indicators such as stride length, gait speed, and sway amplitude following taVNS application. The findings suggest that taVNS has the potential to support motor function in patients with Parkinson's disease. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır INSOMNIA (SLEEP DISORDER) Groundbreaking Technologies for Life What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Insomnia Acute insomnia : It refers to the short-term appearance of insomnia. Acute insomnia usually occurs after a stressful day or on days when mental tension is high. Our body clock has a har d time showing when it's time to rest on such difficult days. This irregularity, which usually lasts for 1 to 2 days, continues until we feel better. There are signs of acute insomnia that can last up to 4 weeks. Chronic insomnia: A sleep disorder that lasts for 1 month or more is called chronic insomnia. A large proportion of 10-15% of adults suffer from chronic in somnia. Compared to acute insomnia, chronic insomnia requires medical attention. The main cause of this type of disorder is usually the presence of major depression. Hypersomnia: characterized by excessive sleepiness and excessive daytime sleep requirements. It is less common than insomnia. Narcolepsy : Includes excessive daytime sleepiness and abnormal findings in daily REM sleep for at least 3 months. Narcolepsy is an abnormality in the sleep mechanism, especially in the REM mechanism. Treatment Options for Insomnia Sleep Techniques The flow of air in and out of the lungs during breathing Blood oxygen levels. Body position. More information CPAP Titration (Mask Therapy) In some cases of severe depression, hospitalization is necessary. This may be necessary if the individual is unable to care for themselves properly or is in danger of harming themselves or others. More information Polysomnography In other words, a sleep test is a procedure that uses devices to record sleep throughout the night to determine the quality of sleep and identify the cause of sleep disturbances. More information Transcutaneous Vagus Nerve Stimulation (tVNS) The vagus nerve facilitates communication between the gut and the brain. When you're unhappy, the vagus nerve senses that something is wrong and activates the sympathetic nervous system, a key component of the digestive system, which then releases cortisol. More information WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

Start a New Era in Clinical Practice with tVNS® A drug-free and non-surgical solution that improves your quality of life: tVNS® is a scientifically proven treatment that supports body balance by non-invasively stimulating the vagus nerve through the ear. This innovative system, which applies precise stimulation to the cymba concha region, offers personalized therapy with wireless parameter settings. Approved as a Class IIa medical device under the European Union Medical Devices Directive (EU-MDR), tVNS® meets the highest standards for safety and effectiveness. tVNS® R Transcutaneous Vagus Nerve Stimulation Device Full Wireless Parameter Programmability Patient Application for Data Collection Support for Clinical Research Triggered tVNS® Legacy and Hook Electrode Sham Stimulation Leading Healthcare Organizations Worldwide Trust tVNS® Devices To play, press and hold the enter key. To stop, release the enter key. Why Are We Pioneers in This Field with tVNS®? We Offer Reliable and Scientific Solutions with Over 20 Years of Experience For over twenty years, we have been pioneering the field with our innovative work in non-invasive vagus nerve stimulation. Our devices were developed in Germany using advanced technology, and their effectiveness has been validated through clinical studies. Approved as a Class IIa medical device under EU-MDR, tVNS® stands out in the clinical field not only for its effectiveness but also for its reliability and low side effect profile. In today's world, where scientifically unverified practices are becoming increasingly common, tVNS® offers an evidence-based and approved treatment method. Since we first introduced the Cerbomed Nemos® device, we have maintained our market leadership in vagus nerve technologies. tVNS® systems, preferred both clinically and in research, distinguish themselves with their safety, precision, and user-friendliness. Prioritizing patient comfort and long-term benefits, our devices are manufactured to the highest quality standards at our production center in Germany. Because we believe in the safe start of the healing process. What is tVNS®? Non-Invasive Vagus Nerve Stimulation in the Treatment of Neurological Diseases In cases where pharmacological or invasive treatment approaches are inadequate or cause undesirable side effects, tVNS® offers an effective and comfortable treatment option for patients. The vagus nerve, which plays a central role in our body's nervous system, is critical for maintaining internal balance (homeostasis). tVNS® (Transcutaneous Vagus Nerve Stimulation) harnesses the therapeutic potential of this nerve by targeting its auricular branch, which is accessible in the ear. This innovative method modulates vagus nerve activity with low-intensity electrical stimulation and aims to promote balance among body systems. This reduces the symptoms of neurological disorders associated with sympathovagal imbalance. Furthermore, this effect is achieved without the need for surgery or the side effects of medications. Approved as a Class IIa medical device under the European Medical Device Regulation (EU-MDR), tVNS® sets a new standard by combining efficacy, safety and ease of use in the treatment of neurological diseases. tVNS® is indicated for the treatment of the following clinical conditions: ✓Anxiety ✓Atrial Fibrillation ✓Autism ✓Cognitive Disorders ✓Depression ✓Epilepsy ✓Crohn's Disease ✓Inflammatory Bowel Disease ✓Migraine ✓Parkinson ✓Prader-Willi Syndrome ✓Sleep Disorders ✓Systemic Sclerosis ✓Tinnitus Why Choose tVNS® Device? tVNS®: The Only Non-Invasive Vagus Nerve Stimulation Device with EU-MDR Approval tVNS® is the only non-invasive vagus nerve stimulation device approved as a Class IIa medical device under the European Medical Device Regulation (EU-MDR). This innovative, clinically validated, non-surgical method offers a safer and more comfortable alternative to invasive procedures. Using patented electrode technology, it provides maximum effectiveness by stimulating the concha cymba, targeting the auricular branch of the vagus nerve (100% innervation). Unlike other devices that only provide partial innervation, tVNS® is a unique solution that maximizes effectiveness in this regard. EU-MDR Cla ss IIa EU-MDR Approved Medical Device tVNS® is the only non-invasive vagus nerve stimulation (VNS) device approved under the European Medical Device Regulation (EU-MDR). Our device has a unique stimulation technology that targets the cymba concha region, providing 100% innervation of the auricular branch of the vagus nerve. Unlike other devices on the market, they provide partial innervation by stimulating different anatomical areas and are not manufactured to the same quality and safety standards as tVNS®. Non-Surgical Clinical Approach tVNS® provides the clinical effectiveness of vagus nerve stimulation without the risks and operational difficulties associated with surgical interventions. In this way, patients can benefit from significant therapeutic benefits in a non-invasive way and under their own application control. Minimal Side Effects The process of moving away from pharmacological treatments often goes hand in hand with the search for fewer side effects. tVNS®, a drug-free method, offers a safer treatment alternative by reducing the risk of long-term adverse effects. German Engineering and Production Quality Our commitment to excellence ensures that every tVNS® device meets the highest standards for quality and performance. Our devices are developed with durability and innovative design in mind, reflecting Germany's long-established engineering and manufacturing precision. With tVNS®, you invest in a technology focused on clinical success, trusted by healthcare professionals and researchers worldwide. Mobile App-Supported Therapy Experience Tracking and understanding your treatment progress is critical to clinical success. The tVNS® Patient mobile application developed for this purpose not only provides real-time monitoring but also enables seamless sharing of data with healthcare professionals. Access from Anywhere In today's world, remote access is of great importance for patient comfort. In response to this need, tVNS® offers a combination of device delivery directly to the patient's address and distance learning support. In this way, patients can easily begin their treatment process without the necessity of travel or logistical restrictions. Pediatric Compatibility tVNS® has been rigorously designed and approved for use in children. In this way, it fills an important gap in pediatric treatment in a safe and effective manner. Easy to Use Functionality should not compromise on simplicity. Standing out with its advanced technology, the tVNS® device is also as user-friendly as a smartphone and can be effortlessly integrated into your daily routine. tVNS® treatment stands out for its ease of use and integration into daily life . At the heart of this method is the principle of neurostimulation, which utilizes the vagus nerve's ability to influence various bodily functions and systems. tVNS® stimulates the auricular branch of the vagus nerve (ABVN) with gentle electrical impulses delivered through the skin. These impulses generate therapeutic signals that are transmitted first to the brainstem and then to higher centers, aiming to alleviate disorders within the nervous system. The device is designed with a completely patient-centered approach: easy to use, portable, and discreet. This allows you to integrate treatment sessions into your schedule without disrupting your daily routine. Whether you're at home, at work, or traveling, tVNS® offers a consistent and accessible solution for managing the symptoms of neurological disorders, including reducing seizure frequency in epilepsy. Each session with the tVNS® device is a step toward rebalancing the nervous system. This method uses the body's natural pathways to support healing and symptom relief. The device's ease of use makes starting and maintaining treatment extremely convenient. This empowers users to take control of their health through a non-invasive and effective method. Mechanism of Action of tVNS® Therapy tVNS® is designed to be portable and easy for patients to use at any time of the day and in any environment they choose. tVNS® Clinical Research and Patient Tracking Application Two Apps Integrated with Your tVNS® R Device: tVNS® Research and tVNS® Patient Your tVNS® R device provides access to two applications developed for research and patient monitoring: tVNS® Research and tVNS® Patient. The tVNS® Research app allows all technical parameters to be easily reprogrammed and transmitted wirelessly to the device. This gives researchers the flexibility to experiment with entirely new stimulation protocols. Technical and patient data can also be collected and securely stored through the app. The tVNS® Patient app automatically records all stimulation data (application time, duration, parameters, etc.). Additionally, it offers a structured survey module where patients can provide feedback on their experience. The tVNS® Patient app is fully compliant with the General Data Protection Regulation (GDPR). This means patient data is processed and stored in accordance with the highest confidentiality and security standards. tVNS® Technology Supported by Clinical Research Multi-center clinical studies and scientific research demonstrate the proven efficacy and safety of tVNS®. Thanks to our unique stimulation approach focused on the cymba concha region, our high quality standards, and our strong clinical data base, tVNS® has become a preferred neurotherapeutic solution for researchers. This holistic approach positions tVNS® at the forefront of innovation and patient-centered care in the field of neuromodulation. Epilepsy After 20 weeks of treatment, patients receiving active tVNS® had an average 34.2% reduction in seizure frequency. Prader-Willi-Syndrome After 12 months of treatment, 80% of patients treated with tVNS® had an average 50% reduction in the number of daily seizures/attacks compared to pre-treatment levels. Depression tVNS® administration, when used in conjunction with psychopharmacological treatment and psychotherapy, resulted in a reduction of at least 2–3 points in depression-specific HAMD scores in adult patients after a 9-week period. Migraine tVNS® treatment resulted in a 50% reduction in the frequency of migraine days after 12 weeks of treatment. Click for more information and clinical studies about the tVNS® Research device. tVNS® Research devices Clinical Research Enter a New Era in Patient Treatment with tVNS® Discover how tVNS® can transform your treatment approach. Incorporate this innovative solution into your practice, offering a safe and non-invasive way to heal your patients who haven't seen satisfactory results with conventional treatment methods. Let's take a step together to pioneer an innovative and people-centered approach to healthcare. Contact our expert experts to learn more about how you can integrate tVNS® into your clinical practice and the benefits it can provide for your patients. Together, let's pave the way for a healthier future and a higher quality of life. Contact us