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About us The medical technology company Cerbomed GmbH, which was founded in 2003 in Erlangen, led the world in the field of transcutaneous vagus nerve stimulation until 2018. In October 2018, the brand was restructures as tVNS Technologies Gmbh. The new generation device, tVNS®, approved in 2021, is the only non-invasive vagus stimulation device in the world approved for epilepsy, depression, autism, insomnia and many other neurodegenerative diseases. tVNS® has been used in thousands of treatments since 2010 and has significantly improved patients' quality of life. tVNS® devices has been developed and manufactured in Germany. tVNS Health GmbH, based in Munich, Germany is responsible for the worldwide sales and therapy support services for tVNS® devices, serving in more than 40 countries worldwide. Nervovita Medikal Teknolojiler is a medical technology company established by tVNS Health GmbH to carry out its activities in Turkey, Azerbaijan and Balkans, and provides tVNS therapy devices to hundreds of patients. Meet our team About us The medical technology company Cerbomed GmbH, which was founded in 2003 in Erlangen, led the world in the field of transcutaneous vagus nerve stimulation until 2018. In October 2018, the brand was restructures as tVNS Technologies Gmbh. The new generation device, tVNS®, approved in 2021, is the only non-invasive vagus stimulation device in the world approved for epilepsy, depression, autism, insomnia and many other neurodegenerative diseases. tVNS® has been used in thousands of treatments since 2010 and has significantly improved patients' quality of life. tVNS® devices has been developed and manufactured in Germany. tVNS Health GmbH, based in Munich, Germany is responsible for the worldwide sales and therapy support services for tVNS® devices, serving in more than 40 countries worldwide. Nervovita Medikal Teknolojiler is a medical technology company established by tVNS Health GmbH to carry out its activities in Turkey, Azerbaijan and Balkans, and provides tVNS therapy devices to hundreds of patients. About us The medical technology company Cerbomed GmbH, which was founded in 2003 in Erlangen, led the world in the field of transcutaneous vagus nerve stimulation until 2018. In October 2018, the brand was restructures as tVNS Technologies Gmbh. The new generation device, tVNS®, approved in 2021, is the only non-invasive vagus stimulation device in the world approved for epilepsy, depression, autism, insomnia and many other neurodegenerative diseases. tVNS® has been used in thousands of treatments since 2010 and has significantly improved patients' quality of life. tVNS® devices has been developed and manufactured in Germany. tVNS Health GmbH, based in Munich, Germany is responsible for the worldwide sales and therapy support services for tVNS® devices, serving in more than 40 countries worldwide. Nervovita Medikal Teknolojiler is a medical technology company established by tVNS Health GmbH to carry out its activities in Turkey, Azerbaijan and Balkans, and provides tVNS therapy devices to hundreds of patients. Our Vision The patient is at the center of all our activities - customer proximity and customer satisfaction are extremely important to us. Our vision is to increase the quality of life of patients and their loved ones with our solutions, to give them a new life for the future, and to provide a more predictable life. We support our patients in their pursuit of safety, stability, and self-control. İletişim Bilgileri Contact us tvNS Health GmbH Türkiye - Azerbaijan - Northern Cyprus - North Macedonia Office NERVOVITA Medical Technologies RELUX Plaza, FSM Mah Poligon Cad Siir Sok Floor :9 No:58 34771, Umraniye /Istanbul /TURKEY Whatsapp Link +90 850 241 93 15 info@t-vnstherapy.com Our Socia Media Channels tVNS Health GmbH Headquater Südliche Münchner Str. 62, 82031 Grünwald, Germany info@tvns.health www.t-vns.com Whatsapp Link +49 89 24410244 info@tvns.health Our Socia Media Channels Contact us Name Surname Your E-mail Address Phone Number Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible.

PATIENT DECLARATION FORM CLINICAL DIAGNOSIS & HEALTH CONDITIONS

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Cognitive Impairment Groundbreaking Technologies for Life What is Cognitive Impairment? The shrinkage caused by the loss of cells in the brain causes various functional disorders. These dysfunctions may manifest as dementia, Alzheimer, and mild cognitive impairment, which are common in people ives. People with cognitive impairment are at high risk for Alzheimer and dementia. When adequate precautions are taken, cognitive impairment may regress, and it is possible for these people to lead a normal life. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Cognitive Disorder Dementia It is the inadequacies experienced in language, skills and orientation, especially forgetfulness. Dementia is a family that includes many different types. There are Alzheimer's, dementia due to chronic cerebrovascular disease, alcoholic dementia, depressive dementia, dementia due to infections, etc. Dementia occurs as a result of general deterioration of the upper level functions of the cerebral cortex, especially over 75 years of age, with advancing age. There are dementias that start with memory impairment such as Alzheimer's disease, as well as behavioral disorders, skill disorders, depression, There are also dementias that start with the symptoms of parkinson's disease and language disorders. It is a progressive disease. Alzheimer It is the most common type of dementia is a neurological disease that causes the destruction of brain cells. The disease, which causes a decrease in thought, memory and behavioral functions, occurs after a long time with advancing age. It may take years for the disease to reach advanced stages. Because it is a progressive disease, Alzheimer's patients experience problems such as inability to perform their daily tasks, forgetfulness and serious confusion. People with memory loss or other possible Alzheimer's symptoms may have trouble recognizing that they have a problem. Treatment Options for Cognitive Disorder There is no drug therapy approved to treat cognitive impairment. Medicines used to treat symptoms of Alzheimer's disease have been tried. Some studies have found that using these drugs for cognitive impairment is helpful, while others have concluded that there is no benefit. It has been noted that the use of other drugs, including NSAIDs, Ginkgo, Biloba and vitamin E, does not provide a great benefit. tVNS Effect Mechanism There are many clinical studies in recent years that cognitive disorders are caused by inflammation in the brain. Although the basic efficacy mechanism of tVNS has not been fully resolved, our new generation devices in 2021 became the first neuromodulation therapy approved for cognitive impairment in the world, due to both its benefits in the treatment of inflammation and the increase in neuroplasticity. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır INSOMNIA (SLEEP DISORDER) Groundbreaking Technologies for Life What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Tinnitus and Vagus Nerve Stimulation Is tVNS® treatment painful? No. The tVNS® device delivers mild electrical impulses through the ear. Patients typically feel this as a tingling or gentle vibration. Do I need to use the device every day? Yes, regular use is important for optimal treatment results. The duration and frequency of application are determined by factors such as the patient's age and indication. Are there any side effects? Side effects of tVNS® treatment are generally mild. A rare side effect is mild skin irritation at the application site. How long does it take to see results? Some patients experience positive changes in sleep and mood within the first weeks, while reductions in tinnitus intensity may be noticeable within a few weeks to months. Tinnitus and Vagus Nerve Stimulation Individuals whose sleep and quality of life are impaired due to tinnitus Those seeking treatment without medication or surgery Patients with high psychological impact (anxiety, restlessness) Users who prefer a minimally invasive and safe method Contact us Contact us

Start a New Era in Clinical Practice with tVNS® A drug-free and non-surgical solution that improves your quality of life: tVNS® is a scientifically proven treatment that supports body balance by non-invasively stimulating the vagus nerve through the ear. This innovative system, which applies precise stimulation to the cymba concha region, offers personalized therapy with wireless parameter settings. Approved as a Class IIa medical device under the European Union Medical Devices Directive (EU-MDR), tVNS® meets the highest standards for safety and effectiveness. tVNS® R Transcutaneous Vagus Nerve Stimulation Device Full Wireless Parameter Programmability Patient Application for Data Collection Support for Clinical Research Triggered tVNS® Legacy and Hook Electrode Sham Stimulation Leading Healthcare Organizations Worldwide Trust tVNS® Devices To play, press and hold the enter key. To stop, release the enter key. Why Are We Pioneers in This Field with tVNS®? We Offer Reliable and Scientific Solutions with Over 20 Years of Experience For over twenty years, we have been pioneering the field with our innovative work in non-invasive vagus nerve stimulation. Our devices were developed in Germany using advanced technology, and their effectiveness has been validated through clinical studies. Approved as a Class IIa medical device under EU-MDR, tVNS® stands out in the clinical field not only for its effectiveness but also for its reliability and low side effect profile. In today's world, where scientifically unverified practices are becoming increasingly common, tVNS® offers an evidence-based and approved treatment method. Since we first introduced the Cerbomed Nemos® device, we have maintained our market leadership in vagus nerve technologies. tVNS® systems, preferred both clinically and in research, distinguish themselves with their safety, precision, and user-friendliness. Prioritizing patient comfort and long-term benefits, our devices are manufactured to the highest quality standards at our production center in Germany. Because we believe in the safe start of the healing process. What is tVNS®? Non-Invasive Vagus Nerve Stimulation in the Treatment of Neurological Diseases In cases where pharmacological or invasive treatment approaches are inadequate or cause undesirable side effects, tVNS® offers an effective and comfortable treatment option for patients. The vagus nerve, which plays a central role in our body's nervous system, is critical for maintaining internal balance (homeostasis). tVNS® (Transcutaneous Vagus Nerve Stimulation) harnesses the therapeutic potential of this nerve by targeting its auricular branch, which is accessible in the ear. This innovative method modulates vagus nerve activity with low-intensity electrical stimulation and aims to promote balance among body systems. This reduces the symptoms of neurological disorders associated with sympathovagal imbalance. Furthermore, this effect is achieved without the need for surgery or the side effects of medications. Approved as a Class IIa medical device under the European Medical Device Regulation (EU-MDR), tVNS® sets a new standard by combining efficacy, safety and ease of use in the treatment of neurological diseases. tVNS® is indicated for the treatment of the following clinical conditions: ✓Anxiety ✓Atrial Fibrillation ✓Autism ✓Cognitive Disorders ✓Depression ✓Epilepsy ✓Crohn's Disease ✓Inflammatory Bowel Disease ✓Migraine ✓Parkinson ✓Prader-Willi Syndrome ✓Sleep Disorders ✓Systemic Sclerosis ✓Tinnitus Why Choose tVNS® Device? tVNS®: The Only Non-Invasive Vagus Nerve Stimulation Device with EU-MDR Approval tVNS® is the only non-invasive vagus nerve stimulation device approved as a Class IIa medical device under the European Medical Device Regulation (EU-MDR). This innovative, clinically validated, non-surgical method offers a safer and more comfortable alternative to invasive procedures. Using patented electrode technology, it provides maximum effectiveness by stimulating the concha cymba, targeting the auricular branch of the vagus nerve (100% innervation). Unlike other devices that only provide partial innervation, tVNS® is a unique solution that maximizes effectiveness in this regard. EU-MDR Cla ss IIa EU-MDR Approved Medical Device tVNS® is the only non-invasive vagus nerve stimulation (VNS) device approved under the European Medical Device Regulation (EU-MDR). Our device has a unique stimulation technology that targets the cymba concha region, providing 100% innervation of the auricular branch of the vagus nerve. Unlike other devices on the market, they provide partial innervation by stimulating different anatomical areas and are not manufactured to the same quality and safety standards as tVNS®. Non-Surgical Clinical Approach tVNS® provides the clinical effectiveness of vagus nerve stimulation without the risks and operational difficulties associated with surgical interventions. In this way, patients can benefit from significant therapeutic benefits in a non-invasive way and under their own application control. Minimal Side Effects The process of moving away from pharmacological treatments often goes hand in hand with the search for fewer side effects. tVNS®, a drug-free method, offers a safer treatment alternative by reducing the risk of long-term adverse effects. German Engineering and Production Quality Our commitment to excellence ensures that every tVNS® device meets the highest standards for quality and performance. Our devices are developed with durability and innovative design in mind, reflecting Germany's long-established engineering and manufacturing precision. With tVNS®, you invest in a technology focused on clinical success, trusted by healthcare professionals and researchers worldwide. Mobile App-Supported Therapy Experience Tracking and understanding your treatment progress is critical to clinical success. The tVNS® Patient mobile application developed for this purpose not only provides real-time monitoring but also enables seamless sharing of data with healthcare professionals. Access from Anywhere In today's world, remote access is of great importance for patient comfort. In response to this need, tVNS® offers a combination of device delivery directly to the patient's address and distance learning support. In this way, patients can easily begin their treatment process without the necessity of travel or logistical restrictions. Pediatric Compatibility tVNS® has been rigorously designed and approved for use in children. In this way, it fills an important gap in pediatric treatment in a safe and effective manner. Easy to Use Functionality should not compromise on simplicity. Standing out with its advanced technology, the tVNS® device is also as user-friendly as a smartphone and can be effortlessly integrated into your daily routine. tVNS® treatment stands out for its ease of use and integration into daily life . At the heart of this method is the principle of neurostimulation, which utilizes the vagus nerve's ability to influence various bodily functions and systems. tVNS® stimulates the auricular branch of the vagus nerve (ABVN) with gentle electrical impulses delivered through the skin. These impulses generate therapeutic signals that are transmitted first to the brainstem and then to higher centers, aiming to alleviate disorders within the nervous system. The device is designed with a completely patient-centered approach: easy to use, portable, and discreet. This allows you to integrate treatment sessions into your schedule without disrupting your daily routine. Whether you're at home, at work, or traveling, tVNS® offers a consistent and accessible solution for managing the symptoms of neurological disorders, including reducing seizure frequency in epilepsy. Each session with the tVNS® device is a step toward rebalancing the nervous system. This method uses the body's natural pathways to support healing and symptom relief. The device's ease of use makes starting and maintaining treatment extremely convenient. This empowers users to take control of their health through a non-invasive and effective method. Mechanism of Action of tVNS® Therapy tVNS® is designed to be portable and easy for patients to use at any time of the day and in any environment they choose. tVNS® Clinical Research and Patient Tracking Application Two Apps Integrated with Your tVNS® R Device: tVNS® Research and tVNS® Patient Your tVNS® R device provides access to two applications developed for research and patient monitoring: tVNS® Research and tVNS® Patient. The tVNS® Research app allows all technical parameters to be easily reprogrammed and transmitted wirelessly to the device. This gives researchers the flexibility to experiment with entirely new stimulation protocols. Technical and patient data can also be collected and securely stored through the app. The tVNS® Patient app automatically records all stimulation data (application time, duration, parameters, etc.). Additionally, it offers a structured survey module where patients can provide feedback on their experience. The tVNS® Patient app is fully compliant with the General Data Protection Regulation (GDPR). This means patient data is processed and stored in accordance with the highest confidentiality and security standards. tVNS® Technology Supported by Clinical Research Multi-center clinical studies and scientific research demonstrate the proven efficacy and safety of tVNS®. Thanks to our unique stimulation approach focused on the cymba concha region, our high quality standards, and our strong clinical data base, tVNS® has become a preferred neurotherapeutic solution for researchers. This holistic approach positions tVNS® at the forefront of innovation and patient-centered care in the field of neuromodulation. Epilepsy After 20 weeks of treatment, patients receiving active tVNS® had an average 34.2% reduction in seizure frequency. Prader-Willi-Syndrome After 12 months of treatment, 80% of patients treated with tVNS® had an average 50% reduction in the number of daily seizures/attacks compared to pre-treatment levels. Depression tVNS® administration, when used in conjunction with psychopharmacological treatment and psychotherapy, resulted in a reduction of at least 2–3 points in depression-specific HAMD scores in adult patients after a 9-week period. Migraine tVNS® treatment resulted in a 50% reduction in the frequency of migraine days after 12 weeks of treatment. Click for more information and clinical studies about the tVNS® Research device. tVNS® Research devices Clinical Research Enter a New Era in Patient Treatment with tVNS® Discover how tVNS® can transform your treatment approach. Incorporate this innovative solution into your practice, offering a safe and non-invasive way to heal your patients who haven't seen satisfactory results with conventional treatment methods. Let's take a step together to pioneer an innovative and people-centered approach to healthcare. Contact our expert experts to learn more about how you can integrate tVNS® into your clinical practice and the benefits it can provide for your patients. Together, let's pave the way for a healthier future and a higher quality of life. Contact us

PATIENT DECLARATION FORM CLINICAL DIAGNOSIS & HEALTH CONDITIONS Please click the button to download the guide: Download document

FAQs Frequently Asked Questions Am I suitable for treatment with tVNS®? 1 tVNS® is a non-invasive device used in the treatment of sympathetic vagal imbalances. It can be used in patients of all ages from 3 years of age. It can be used at any age from newborns with the approval of the doctor. In general, whether you are suitable for treatment is a decision that you will make in consultation with your doctor. If your doctor does not recommend or does not know the treatment, you can contact us. We can contact your doctor . What does it mean for the tvNS® device to be medically approved? 2 The manufacturer of the tVNS® therapy device, Germany-based tVNS Tehnologies GmbH, was established in Germany in 2003 and, as the world's pioneer of this technology, manages the worldwide clinical research and operations of the devices that have received the first medical approval in the world since 2010. With the medical approvals received in 2021 and 2023, it is the only auricular stimulation device that can safely apply vagus nerve treatment and is produced with the latest engineering technologies with the R&D and production team in Erlangen, Germany. Stimulation of the vagus nerve with devices that do not have safety and medical approval can lead to very serious consequences ranging from respiratory to cardiac arrest. Do I need to consult my doctor or device manufacturer for device settings when starting to use tVNS®? 3 No. tVNS® is very easy to use. It can be easily adjusted without the support of a doctor with the device training and instructions for use. When you receive the device, approximately 2 hours of device usage training is given. Afterwards, all settings related to the device are made by Turkey with a remote Bluetooth-supported application. Your therapy protocol is shared with your doctor on a regular basis. How often do I need to use tVNS®? 4 Therapy with tVNS® requires a total of 2 to 4 hours of sessions per day, depending on the indication used. The duration of these sessions can be planned as 1.5 hours. The time at which it will be is determined according to both the indication used and the daily routines and needs of the patient. What side effects might I experience? 5 Therapy with tVNS® is a treatment with very few side effects. In general, two types of side effects are observed. The first of these is local side effects that may occur in the form of itching, redness and pressure sores in the area where the outer auricle is stimulated. On the other hand, since the stimulation of the vagus nerve can affect the autonomic nervous system, systemic side effects may occur. These may include headache, nausea, or dizziness. As with other drug or neurostimulation treatments, an increase in seizures may occur. However, it differs from other treatments in that the side effects usually disappear soon after the end of treatment. Can I avoid taking medication if I choose tvNS ® treatment? 6 tVNS® therapy is an adjunct to medication, if you decide to stop or reduce your medication you should discuss this with your doctor. In general, it is not recommended to start a new drug, increase or decrease the dose, or start it simultaneously with another treatment at the time of initiation of treatment. In this way, we can observe the effects of tVNS® more objectively. How long will I need to use tVNS® treatment and how long will it take for the treatment to work? 7 tVNS® treatment is not an acute treatment, there is no external drug intake. It provides a long-term treatment option by stimulating certain centers of the brain and increasing the release of neurotransmitters over time, eliminating the sympathovagal imbalance. Like most drugs and neuromodulatory therapies for epilepsy treatment, tVNS® therapy is a long-term therapy. Even if you do respond to treatment with tVNS®, the effect usually starts with a delay of just a few weeks to months. Can tVNS ® be used by children? 8 tVNS® can be safely used by children under parental supervision. It was applied to two different 8 and 9 months old babies with the approval of a doctor in Turkey and no negative results were encountered. If it will be used with children, the sessions must be given under parental supervision. tVNS® can be used by children 6 years and older. If it is to be used in children younger than 6 years old, the sessions must be performed under the supervision of the parents. How can I access tvNS ® ? 9 If deemed appropriate by your doctor for the treatment of tVNS®, you can apply to our center and obtain the device. After planning how to use the device and the treatment protocol, you can start the treatment by receiving remote treatment support. 1 0 What are the approved indications of the device? Indicated since 2021 for Anxiety, Migraine, Autism, Cognitive Impairment, Depression, Fibromyalgia, Epilepsy, Inflammation, Prader-Willi Syndrome, Sleep Disorders, Stroke, Tinnitus, Asthma, Crohn's Disease, Atrial Fibrillation and Parkinson's. Apart from this, researches continue on different subjects such as neural plasticity, coma and diabetes. To what extent does tVNS ® treatment affect epileptic seizures? 11 According to clinical studies conducted in 2000 patients using the tVNS® device between 2010 and 2018, a significant reduction in the severity and number of seizures was observed in an average of 60% of the patients. It can be said that a secondary effect, which is widely seen, is an increase in vitality, cognitive progress and improvement in sleep patterns. It can completely stop seizures in 10-20% of patients. What are the indications (effects) of the t-VNS ® device? 12 1) It undertakes the task of increasing the activity of the parasympathetic nervous system (resting mode). 2) It provides the balance of neurotransmitter hormone that the body cannot produce enough. 3) It helps to increase brain plasticity (Neural plasticity /: the ability of the brain to undergo structural or physiological changes) in the medium and long term. 4) Reducing inflammation. In recent years, clinical studies of tVNS® have proven the inflammatory effects of nerve stimulation. Inflammation (colloquially known as inflammation/inflammation) in the simplest terms, against all kinds of foreign factors or internal-external tissue damage of living tissue; cellular (cellular), body fluid (humoral) or veins (vascular) are some series of reactions on the basis. By developing inflammation, the body actually aims to destroy the disease factor, to isolate the factors that it cannot destroy from healthy tissues or to eliminate damaged tissues. It is divided into acute and chronic inflammation. Examples of acute inflammation: Redness, swelling, fever, pain, edema, increased temperature Examples of chronic inflammation: Cancer, ALS, heart diseases, diabetes, hypertension, asthma, depression, neurological diseases Is the response time of vagal stimulation therapy (vagus nerve stimulation) the same in patients of all ages? 13 It has been observed that the earlier the patient starts vagal nerve stimulation therapy or the shorter the epilepsy history, the shorter the response time to the disease. For example, a 40-year-old epilepsy patient may take longer to respond to vagal nerve stimulation treatment than a pediatric epilepsy patient. Is nonsurgical tVNS (through the skin) vagus nerve stimulation) only a preliminary step for patients responding to surgical VNS therapy? Should epilepsy patients who respond to cutaneous vagus stimulation therapy switch to invasive therapy? 14 tVNS® therapy may be a preliminary step for invasive vagal nerve stimulation requiring surgical intervention, but it is also an alternative treatment modality. The reasons for this are; I. Not every patient is suitable for invasive intervention. II. In case of failure to respond to treatment, removal of the electrode is difficult and risky, as the tissues of the vagus nerve wrap and fuse with the electrode. Even if the battery is removed, the patient will have to live with an inactive implant electrode in his body for life. It may cause pain or pressure, and infection may develop over time. Can the transcutaneous (through the skin conduction/non-invasive) method and the Invasive (surgical implant) method give the same effect in vagal nerve stimulation? 15 According to fMRI studies, it has been proven that both methods stimulate the same points in the brain. However, tVNS® has some advantages over the invasive method: 1. Contrary to the invasive alternative, since it has a rechargeable battery, it can give electrical stimulation as more frequent and intense programs. 2. As with the invasive alternative, high currents up to 5MA can be given, as it does not directly give the electric current attached to the nerve and does not pose the risk of nerve damage. Why does not every patient respond to his treatment in the same way or at the same rate? 16 There are different hypotheses about this, one of them is myelin thickness. Thick myelin nerves conduct electrical conduction better, and in this way vagus nerve stimulation can be done more effectively. Myelin thickness can vary from person to person genetically. Studies have shown that patients with thick myelin nerves respond better to treatment. What is the direct current (milliamps) to stimulate the ear? 17 There are scientifically proven studies on this subject. The minimum electrical current required to stimulate the vagus nerve is kept somewhat below the pain/pain threshold so that it does not activate the pain nerves. For this reason, there should be no pain or pain during stimulation, but a distinct vibration sensation. This is the most optimal stimulation intensity and should be at a level that does not disturb the patient. In which situations can the device not be used during the day? 18 You can safely use the tVNS® device while mobile, while walking, watching TV, reading a book, or at the computer. For safety reasons, it is recommended not to be used while driving to avoid distractions. It is recommended that the device be turned off when passing near high magnetic fields and devices that create high magnetic fields. Apart from this, it can be used in children both while they are asleep and awake. Adults are advised not to sleep while performing self-therapy. In order to avoid the risk of any cable entanglement around the neck, our children can be given therapy both while awake and asleep under parental supervision. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Cognitive Impairment Groundbreaking Technologies for Life There is no drug therapy approved to treat cognitive impairment. Medicines used to treat symptoms of Alzheimer's disease have been tried. Some studies have found that using these drugs for cognitive impairment is helpful, while others have concluded that there is no benefit. It has been noted that the use of other drugs, including NSAIDs, Ginkgo, Biloba and vitamin E, does not provide a great benefit. tVNS Effect Mechanism There are many clinical studies in recent years that cognitive disorders are caused by inflammation in the brain. Although the basic efficacy mechanism of tVNS has not been fully resolved, our new generation devices in 2021 became the first neuromodulation therapy approved for cognitive impairment in the world, due to both its benefits in the treatment of inflammation and the increase in neuroplasticity. Types of Cognitive Disorder Dementia It is the inadequacies experienced in language, skills and orientation, especially forgetfulness. Dementia is a family that includes many different types. There are Alzheimer's, dementia due to chronic cerebrovascular disease, alcoholic dementia, depressive dementia, dementia due to infections, etc. Dementia occurs as a result of general deterioration of the upper level functions of the cerebral cortex, especially over 75 years of age, with advancing age. Treatment Options for Cognitive Disorder Improving memory and attention processes by increasing prefrontal cortex and hippocampal activity Increasing attention and alertness via the noradrenergic system Protecting nerve cells with anti-inflammatory effects (neuroprotection) Reducing stress-induced cognitive impairment by increasing parasympathetic activity Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Findings from Neuroimaging Studies Hafıza ve Öğrenmede Artış MCI ve Demans Riski Altındaki Bireylerde Potansiyel Faydalar fMRI Bulguları ile Desteklenen Beyin Aktivitesi Artışı What is Cognitive Impairment? The shrinkage caused by the loss of cells in the brain causes various functional disorders. These dysfunctions may manifest as dementia, Alzheimer, and mild cognitive impairment, which are common in people ives. People with cognitive impairment are at high risk for Alzheimer and dementia. When adequate precautions are taken, cognitive impairment may regress, and it is possible for these people to lead a normal life. Targeted Cognitive Benefits with tVNS® Memory Improvement in short-term and long-term memory Attention Increased attention and concentration Learning Increased capacity to learn new information Cognitive development Improvement in mental flexibility and decision-making processes Focusing Reduction of stress-induced cognitive clouding These effects make tVNS a valuable supportive tool, especially for older adults, those with post-traumatic cognitive impairment, those with post-depressive cognitive decline, and individuals diagnosed with MCI. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home Hasta tarafından günlük olarak, kendi ev ortamında kolaylıkla kullanılabilir. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Uyarım parametreleri hastaya özel olarak ayarlanabilir. Contact us Contact us

Vagus nerve stimulation for depression DEPRESSION Groundbreaking Technologies for Life What is Depression? Depression is a mood disorder that causes constant sadness and loss of interest. Depression is also called major depressive disorder or clinical depression. The feelings, thoughts and behaviors of individuals suffering from this condition are affected and various emotional or physical problems may arise due to this. There may be problems doing normal daily activities, and sometimes life may seem not worth living. Depression is not just a feeling of malaise or momentary weakness. Depression is also not such a simple problem that it can be solved in an instant. Depression is a treatable medical condition that requires treatment. This treatment process may take a long time in some cases. Everyone goes through periods of not feeling well emotionally and psychologically from time to time. These periods generally last for a certain period of time, depending on the intensity of the troubles and sorrows you experience. However, if your bad periods last longer than two or three weeks and prevent you from doing many of the things you do in your daily life properly; this condition is called depression (major depressive disorder). Targeted Benefits in the Treatment of Depression with tVNS® Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Why Are Alternative Treatment Options Needed? Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Meet tVNS®: A New Approach to Depression Through the Vagus Nerve Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. " The scientific solution for depression: tVNS®. The life of a 17-year-old girl diagnosed with medication-resistant, suicidal depression was completely changed by transcutaneous vagus nerve stimulation. This clinically proven, non-invasive method is especially promising for young individuals. It enables the safe management of depression by affecting the brain's mood centers via the vagus nerve. Key Features of tVNS®: Clinically proven effectiveness, non-invasive and drug-free therapy, the ability to monitor your recovery process, and suitability for pediatric use. " Who is it suitable for? tVNS® can be a complementary solution in the following situations: Individuals experiencing mild, moderate and severe depression Those who do not benefit sufficiently from drug treatment Those seeking alternatives due to drug side effects Those who experience depression along with anxiety and sleep disturbances What is Depression? What is Depression? Depression is a mood disorder that causes constant sadness and loss of interest. Depression is also called major depressive disorder or clinical depression. The feelings, thoughts and behaviors of individuals suffering from this condition are affected and various emotional or physical problems may arise due to this. There may be problems doing normal daily activities, and sometimes life may seem not worth living. Depression is not just a feeling of malaise or momentary weakness. Depression is also not such a simple problem that it can be solved in an instant. Depression is a treatable medical condition that requires treatment. This treatment process may take a long time in some cases. Everyone goes through periods of not feeling well emotionally and psychologically from time to time. These periods generally last for a certain period of time, depending on the intensity of the troubles and sorrows you experience. However, if your bad periods last longer than two or three weeks and prevent you from doing many of the things you do in your daily life properly; this condition is called depression (major depressive disorder). Adolescence is a critical period when depression most frequently begins and treatment-resistant cases are observed. Safe and non-invasive options are needed for adolescents who fail to respond to traditional treatments. Transcutaneous auricular vagus nerve stimulation (taVNS) is a new method that can be applied without the need for surgery by stimulating the vagus nerve through the ear. In this study, a 17-year-old girl with treatment-resistant depression received taVNS treatment for 7.5 months, with daily sessions at home, in conjunction with escitalopram therapy, and under regular monitoring by the clinical team. A total of over 270 sessions were administered, with an average daily use of approximately 3 hours. Aside from mild skin irritation, no serious side effects were observed, and cardiac safety tests were normal. Depression severity decreased during treatment, both as assessed by self-report and clinician assessments. The patient completed high school and entered university, and partial improvements in functioning were noted. The results suggest that taVNS is a feasible, safe, and promising complementary treatment option for adolescents. Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. Types of Depression Symptoms Types of Depression The symptoms caused by major depression are different for each individual. Medical professionals look for various markers or traits that clarify an individual's type of depression. A marker or feature may indicate the presence of a particular type of depression: Anxiety distress : Unusual restlessness or depression with worry about possible events or loss of control. Atypical features : Depression with temporary happiness from certain events, increased appetite, excessive need for sleep, hypersensitivity to rejection, and a feeling of heaviness in the organs. WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us Contact us

tVNS Vagus Stimulation Devices Information Request Form Name Surname Your E-mail Address Phone Number Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible. Home Page

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Migraine Symptoms, Causes and Diagnostic Methods Migraine Symptoms Migraine symptoms usually begin in the teenage years. The probability of its occurrence increases from the last stages of adolescence, and this probability decreases after the age of 35. As it is known in people with migraine, the most common and most severe symptom is headache. This headache can sometimes be so severe that it puts the person in bed. The most common areas of migraine attacks are the back of the head, behind the ears and forehead. Other physical symptoms of migraine are the desire to drink excessively, increase in appetite, diarrhea or constipation depending on the situation, and swelling in the abdomen. In addition to these physical symptoms, people who experience migraine attacks also experience various emotional symptoms. Symptoms such as depressed mood, excessive cheerfulness, excessive stagnation, concentration disorders, olfactory sensitivity, attention deficits, hypersensitivity and an intense desire for sleep can be seen. Migraine Causes Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. Triggers of Migraine Hormonal changes experienced by women Hormone medications, such as oral contraceptives (birth control pills) and hormone replacement therapy Some foodstuffs Stress plays an important role in migraine attacks. Stress at work or home life may be the cause of frequent migraine attacks. Loud noises, bright lights, or exposure to sunlight Changes in sleep and wake patterns Migraine attacks may occur with sexual activity or intense physical exertion. Ambient air pressure or barometric changes can trigger migraines. Medicines; Vasodilators (vasodilators) such as nitroglycerin or oral contraceptives (birth control pills) can worsen migraines. Brain tumor Migraine Diagnostic Methods Diagnosis is made during the interview by a specialist physician. If you are experiencing any of the following symptoms, you should see a doctor immediately; Sudden, severe headache like thunder Fever, stiff neck, confusion, double vision, drowsiness, or slurred speech Worsening of headache, especially after a head injury A headache that develops after coughing, exertion, straining, or a sudden movement New onset headache over 50, Migraine is not known enough and its treatment is not done because patients do not apply to the neurology department and try to control their headaches with painkillers. If you regularly experience migraine attacks and symptoms, it is useful to record them. If you think that the attacks and severity of your headaches have changed, you should definitely see a neurologist as soon as possible. For the diagnosis of epilepsy, the patient's medical history, frequency and severity of seizures, and symptoms are among the points that physicians pay attention to. Sometimes, extreme stress, fatigue, emotional and hormonal changes can also cause seizures. In this sense, not every seizure indicates epilepsy. Physicians can diagnose after listening to patients' stories. Genetic factors take the first place among the causes of migraine headaches. The incidence of migraine in patients with a family history of migraine varies between 40% and 75%. Hormonal changes also cause an increase in migraine attacks. Migraine attacks are 3 times more common in women than in men. Migraine Who has visible Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır INSOMNIA (SLEEP DISORDER) Groundbreaking Technologies for Life What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Treatment Options for Insomnia What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Treatment Options for Insomnia Uykuya Dalma ve Sürdürme Sürelerinde İyileşme Parasempatik Aktivitenin Artışı Uyku Kalitesinde Objektif Artış What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Sleep Tests Air flow in and out of the lungs during breathing Blood oxygen levels. Body position. More information CPAP Titration (Mask Therapy) In some cases of severe depression, hospitalization is necessary. This may be necessary if the individual is unable to care for themselves properly or is in danger of harming themselves or others. More information Polysomnography In other words, a sleep test is a procedure that uses devices to record sleep throughout the night to determine the quality of sleep and identify the cause of sleep disturbances. More information Transcutaneous Vagus Nerve Stimulation (tVNS) The vagus nerve facilitates communication between the gut and the brain. When you're unhappy, the vagus nerve senses that something is wrong and activates the sympathetic nervous system, a key component of the digestive system, which then releases cortisol. More information What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Types of Insomnia Acute insomnia : It refers to the short-term appearance of insomnia. Acute insomnia usually occurs after a stressful day or on days when mental tension is high. Our body clock has a har d time showing when it's time to rest on such difficult days. This irregularity, which usually lasts for 1 to 2 days, continues until we feel better. There are signs of acute insomnia that can last up to 4 weeks. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. Contact us Contact us