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tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Tinnitus Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Contact Us

tVNS Transkutanöz Vagus Sinir Stimülasyonu cihazıdır. Dirençli Epilepsi, Migren ve Depresyon Tedavisinde Ameliyatsız İlaçsız Kulaktan Vagus Sinirini Uyaran Dünyanın CE onaylı Tek Nöroterapi - vagus stimulasyonu- cihazıdır. tVNS Türkiye , "t-vnstherapy "tek yetkili satıcısıdır. Changing the World, Changing the Lives In More than 50 Countries of the World With Our 20 Years of Vagus Treatment Experience We Are Here for a Brand New Quality of Life Our tVNS® health solutions help thousands of patients to discover a brand new quality of life. What is tVNS®? tVNS® is a medical device for the treatment of symptoms of sympathovagal imbalance and was specially developed for patients who are not free of symptoms despite drug therapy. tVNS® stimulates the branch of the vagus nerve in the auricle through the skin with gentle electrical impulses. Signals are passed on to the brain via special nerve fibers: first in the brain stem and then in higher centers. The treatment with tVNS® is applied by patients independently. It has been used by thousands of patients and is a treatment with very few side effects. tVNS® is indicated to treat sympathovagal imbalance in the following conditions: Anxiety Migrain Autism Cognitive Impairment Depression Fibromyalgia E p ilepsy Inflammation Pr ader-Willi Syndrome Sleep Disorders Stroke Tinnitus Asthma Crohn's Disease Atrial Fibrillation Parkinson's tVNS® CARE Therapy Tracking THE MOST EFFECTIVE WAY TO GET RESULTS FROM tVNS®* For patient-driven medical device treatments that the patient can apply at home without the supervision of a doctor, the most important need for the success of the treatment is the preparation of a protocol specific to the patient's needs and the remote follow-up by the doctor and an expert team to see whether the patient can use the device correctly. tVNS Care®, o ur unique digital health service, where a patient-specific program is prepared based on the protocols of similar patients in more than 50 countries and all details of the treatment can be followed online by our expert teams. Why Treatment with tVNS® Device? Customized Therapy t VNS® therapies are customized for each patient, based on indication and needs, so can provide a unique solution for every patient. More Flexibility With the help of the rechargeable battery, it allows several different parameters and treatment protocols. Innovative App With the tVNS® Patient App you can track your treatment, share results with your doctor and get therapy consultation wherever you are R emote Training tVNS® allows remote delivery and training without any need for travel, so that any patient can start using the therapy on their home No Surg ery tVNS® enables non-surgical vagus nerve stimulation with full patient control and no invasive- risks Few Side Effects tVNS® has very few side effects compared to drugs and invasive treatments, and easily tolarable. Pediatric Flexibility It can be used safely at any age from newborn babies with the approval of the doctor. Easy to Use tVNS® is easy to use, as small as a smartphone and can be easily integrated into everyday life. Treatment Stories of tVNS® Patients Our doctor Barış Ekici has contributed a lot to my autistic son Kaan. We have benefited greatly from the tVNS treatment, which is Vagus nerve stimulation. We have seen progress in his word count and awareness. He has become calmer, his hyperactivity has decreased, and his sleep has become more regular. Dr. Nurbanu Gürbüzer, Istanbul, Assoc. Prof. Dr. Barış Ekici, mother of a patient followed up Download the tVNS ® Patient App Meet the Tele-Medicine Technologies of the Future With the innovative tVNS® patient app, you can track your treatment at any time and share your data with your doctor. In addition, the tVNS® patient app enables us to continuously improve our technology and optimize your treatment. The tVNS® Patient App is available now in the Google Play Store and in the Apple App Store (EU-only). How does tVNS® work? You can use tVNS® anytime, anywhere. It is easy to use, portable and discrete. tVNS® activates special nerve fibers through gentle electrical impulses (neurostimulation) via an ear electrode on the ear, stimulating the branch of the vagus nerve in the auricle through the skin, by sending nerve signals to the brainstem and the higher centers. This alleviates symptoms of sympathovagal imbalance, for example reducing seizures in epilepsy. Watch this short video to learn more about our tVNS® health solutions and how tVNS® works. blog Contact us Name Surname Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Your E-mail Address Phone Number Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır IN EPILEPSY Treatment Without Drugs or Surgery Is Possible Benefits of tVNS® in Epilepsy Treatment Alternative to Invasive Surgery It can be performed without surgery. Treatment can be monitored remotely using a mobile app. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own living environment. Approved and Safe It has Class IIa medical device approval under the European Union Medical Device Regulation and Approved by the Turkish Ministry of Health. Complementary to Drug Therapy It can be used alongside AED treatment; there is no need to discontinue treatment. Individualized Therapy Stimulation parameters can be adjusted individually to the patient. Why tVNS® Therapy? In epilepsy treatment, the first-line option is usually antiepileptic drugs (AEDs). For many patients, these medications help control seizures. However, long-term drug use can cause serious side effects. Moreover, in about 30% of epilepsy patients, seizures persist despite medication. This condition is known as drug-resistant epilepsy (DRE) and represents a major clinical challenge. For DRE patients, second-line treatments may include surgical interventions or invasive vagus nerve stimulation (VNS). Yet, these options are not suitable for every patient. Some patients: Are not medically eligible for surgery Fear the risks associated with surgery Do not want a permanent implant Seek alternative solutions with fewer side effects As a result, there is a growing need for non-invasive, home-based, and personalized treatment approaches. Non-invasive vagus nerve stimulation devices such as tVNS® represent a science-based solution that is pioneering a new era in addressing this unmet need. Epilepsy is a chronic central nervous system disorder in which abnormal electrical activity in brain cells causes recurring seizures. Seizures can manifest as loss of consciousness, convulsions, sensory changes, or behavioral abnormalities. Approximately 50 million people worldwide live with epilepsy, making it one of the most common neurological disorders. Antiepileptic drugs (AEDs) are generally used as the first-line treatment for epilepsy. However, approximately 30% of patients with epilepsy do not respond adequately to these treatments. This group is defined as "drug-resistant epilepsy (DRE)." Alternative treatment methods are of great importance for patients with DRE. Why Are New Approaches Necessary in Epilepsy? Why Are New Approaches Necessary in Epilepsy? Drug resistance: Approximately 30% of patients cannot achieve adequate seizure control with medications. Side effects: Side effects such as drowsiness, loss of concentration, weight gain, and mood swings can negatively impact quality of life. Long-term use is necessary: Medications are usually used for life and sudden discontinuation may cause an increase in seizures. High risk: Surgery carries a risk of serious complications such as bleeding, infection, and neurological damage. Limited suitability: Not all patients are suitable for surgery; surgery cannot be performed, particularly in cases where seizure foci cannot be identified or are widespread. Long recovery process: Post-operative recovery may result in a temporary decrease in quality of life. Why Are New Approaches Necessary in Epilepsy? Why Are New Approaches Necessary in Epilepsy? Invasive procedure: The device is surgically implanted in the neck area, which carries surgical risks. Permanent implant: Re-surgery is required to remove or replace the device. Side effects: Side effects such as hoarseness, throat discomfort, and shortness of breath may occur. Treatment: Every change in the implant current requires a hospital visit, and every few years the battery is replaced surgically. Why Are New Approaches Necessary in Epilepsy? Patients who cannot be adequately controlled with medications (IDE) Patients who want to reduce their medication use to avoid long-term side effects of medications Individuals who are not suitable for surgical intervention Patients who wish to experience the mood, mental, and motor development effects of vagus nerve stimulation other than seizures Patients and families seeking non-invasive, at-home therapy Treatment Stories of tVNS® Patients My 7-year-old son with Dravet syndrome had seizure periods that required intensive care treatments every month. We have been using tVNS for 2 years, and we are happy to have a seizure-free life, obtain mental development, and reduction in autism symptoms. Zeliha KORKMAZ, Kayseri, Erciyes University Prof. Dr. Hakan GüMüŞ WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Crohn's Disease Groundbreaking Technologies for Life What is Crohn's Disease ? Crohn's disease is a type of inflammatory bowel disease that causes inflammation of the gastrointestinal tract from the mouth to the anus. This inflammation can be attached to one or more parts of the digestive system, but it is usually seen in the ileum, which is the last part of the small intestine, and in the beginning of the large intestine. Crohn's disease can cause inflammation in your digestive tract, leading to abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition. Growth-development retardation in children may be signs of Crohn's disease. Extra-intestinal diseases are also observed in a quarter of Crohn's patients. These mostly occur in the skin, joints, eyes, liver and biliary tract, kidney and urinary tract, vascular heart and lungs. Crohn's Disease Symptoms Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Insomnia Diagnostic Methods Crohn's Disease Causes Immune system: It is possible for a virus or bacteria to trigger Crohn's disease; however, scientists have yet to identify such a trigger. When your immune system tries to fight off the invading microorganism, an abnormal immune response can cause the immune system to attack cells in the digestive tract as well. Heredity: Crohn's disease is more common in people with a family history of the same disease, so genes may play a role in the occurrence of the disease. Crohn's Disease Diagnostic Methods Blood analysis stool analysis Stomach, small and large intestine films Colonoscopy and endoscopy CT and MRI images Crohn's disease can occur at any age, but it usually occurs when the disease is young. Most people who develop Crohn's disease are diagnosed before they reach the age of about 30. You are at higher risk for the disease if you have a first-degree relative with the disease, such as a parent, sibling, or child. About 1 in 5 people with Crohn's disease have a family member with the disease. Facts About Crohn's Disease Treatment Options for Crohn's Disease Drug Therapy Steroid medications: These are medications that reduce inflammation in the digestive system. More information Surgical Treatment Many people with Crohn's disease may require surgical treatment. More information Crohn's Disease Diet In general, the patient is given a diet that is high in energy, high in protein, low in fiber, low in fat, and rich in vitamins and minerals. More information Transcutaneous Vagus Nerve Stimulation (tVNS) tVNS-L ® reduces inflammation in the intestine, allowing the intestine to perform its function more healthily. More information Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır insomnia Symptoms, Causes and Diagnostic Methods Insomnia Symptoms Difficulty falling asleep, waking up before expected, Not feeling fresh after sleep, Being angry and aggressive, Feeling tired and sluggish during the day, Difficulty with coordination and focus, Having difficulty remembering events, Being sleepy during the day, Worrying about sleep, Increase in the number of errors and accidents, Hyperactivity, Mood disorders, Anxiety and depression. Causes of Insomnia Stress Environmental disturbances (noise, light, or extreme heat/cold) Disruption of normal sleep patterns (Travel or a newborn baby) Jetlag after travel Medication use for various ailments The cause of the emergence of chronic insomnia. Unlike acute insomnia chronic diseases can also cause mental tension. Asthma chronic body aches heart palpitations chronic stress Depression drug use emotional or physical discomfort Thyroid diseases psychological reasons Insomnia Diagnostic Methods He or she may perform a physical exam to look for signs of medical problems that may be related to insomnia. While investigating the underlying physical diseases that may cause insomnia, it is also investigated whether there is a problem with the thyroid. If deemed necessary, reports of high-resolution imaging methods such as MRI may be requested. For a definitive diagnosis of insomnia, the doctor may request a chart of one or two weeks of sleep patterns or an overnight follow-up at the patient's sleep clinic. Thus, how long you stay awake at night, breathing movements, brain waves and body activities can be monitored and recorded. People with Insomnia Researchers state that 30% to 40% of adults try to cope with insomnia every year. According to the National Sleep Epidemiology Survey (TAPES) in Adults in Turkey, the incidence of insomnia is 15% (Male: 10.5%, Female: 20.2%). Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Cognitive Impairment Symptoms, Causes and Diagnostic Methods Cognitive Disorder Symptoms Forgetfulness Lack of attention Excitement Unrest Speech difficulties Sleep disorder Causes of Cognitive Impairment Although the exact cause of cognitive impairment is not known exactly, the person's predisposition to Alzheimer's and dementia causes this disease. The following situations may also be the cause of cognitive impairment; Thyroid, kidney, or liver problems Depression, anxiety and stress Conditions that affect blood flow in the brain Vitamin B12 deficiency Cognitive Disorder Diagnostic Methods The diagnosis of cognitive disorder is made by neurology and psychiatry specialists. At this stage, it is very important to be accompanied by someone who knows and observes the patient closely. People with Cognitive Disorder The incidence in people over the age of 65 is around 15-20%. People with cognitive impairment are likely to progress to Alzheimer and dementia. However, cognitive impairment may not always be progressive. Contact us

Start a New Era in Clinical Practice with tVNS® A drug-free and non-surgical solution that improves your quality of life: tVNS® is a scientifically proven treatment that supports body balance by non-invasively stimulating the vagus nerve through the ear. This innovative system, which applies precise stimulation to the cymba concha region, offers personalized therapy with wireless parameter settings. Approved as a Class IIa medical device under the European Union Medical Devices Directive (EU-MDR), tVNS® meets the highest standards for safety and effectiveness. tVNS® R Transcutaneous Vagus Nerve Stimulation Device Full Wireless Parameter Programmability Patient Application for Data Collection Support for Clinical Research Triggered tVNS® Legacy and Hook Electrode Sham Stimulation Leading Healthcare Organizations Worldwide Trust tVNS® Devices To play, press and hold the enter key. To stop, release the enter key. Why Are We Pioneers in This Field with tVNS®? We Offer Reliable and Scientific Solutions with Over 20 Years of Experience For over twenty years, we have been pioneering the field with our innovative work in non-invasive vagus nerve stimulation. Our devices were developed in Germany using advanced technology, and their effectiveness has been validated through clinical studies. Approved as a Class IIa medical device under EU-MDR, tVNS® stands out in the clinical field not only for its effectiveness but also for its reliability and low side effect profile. In today's world, where scientifically unverified practices are becoming increasingly common, tVNS® offers an evidence-based and approved treatment method. Since we first introduced the Cerbomed Nemos® device, we have maintained our market leadership in vagus nerve technologies. tVNS® systems, preferred both clinically and in research, distinguish themselves with their safety, precision, and user-friendliness. Prioritizing patient comfort and long-term benefits, our devices are manufactured to the highest quality standards at our production center in Germany. Because we believe in the safe start of the healing process. What is tVNS®? Non-Invasive Vagus Nerve Stimulation in the Treatment of Neurological Diseases In cases where pharmacological or invasive treatment approaches are inadequate or cause undesirable side effects, tVNS® offers an effective and comfortable treatment option for patients. The vagus nerve, which plays a central role in our body's nervous system, is critical for maintaining internal balance (homeostasis). tVNS® (Transcutaneous Vagus Nerve Stimulation) harnesses the therapeutic potential of this nerve by targeting its auricular branch, which is accessible in the ear. This innovative method modulates vagus nerve activity with low-intensity electrical stimulation and aims to promote balance among body systems. This reduces the symptoms of neurological disorders associated with sympathovagal imbalance. Furthermore, this effect is achieved without the need for surgery or the side effects of medications. Approved as a Class IIa medical device under the European Medical Device Regulation (EU-MDR), tVNS® sets a new standard by combining efficacy, safety and ease of use in the treatment of neurological diseases. tVNS® is indicated for the treatment of the following clinical conditions: ✓Anxiety ✓Atrial Fibrillation ✓Autism ✓Cognitive Disorders ✓Depression ✓Epilepsy ✓Crohn's Disease ✓Inflammatory Bowel Disease ✓Migraine ✓Parkinson ✓Prader-Willi Syndrome ✓Sleep Disorders ✓Systemic Sclerosis ✓Tinnitus Why Choose tVNS® Device? tVNS®: The Only Non-Invasive Vagus Nerve Stimulation Device with EU-MDR Approval tVNS® is the only non-invasive vagus nerve stimulation device approved as a Class IIa medical device under the European Medical Device Regulation (EU-MDR). This innovative, clinically validated, non-surgical method offers a safer and more comfortable alternative to invasive procedures. Using patented electrode technology, it provides maximum effectiveness by stimulating the concha cymba, targeting the auricular branch of the vagus nerve (100% innervation). Unlike other devices that only provide partial innervation, tVNS® is a unique solution that maximizes effectiveness in this regard. EU-MDR Cla ss IIa EU-MDR Approved Medical Device tVNS® is the only non-invasive vagus nerve stimulation (VNS) device approved under the European Medical Device Regulation (EU-MDR). Our device has a unique stimulation technology that targets the cymba concha region, providing 100% innervation of the auricular branch of the vagus nerve. Unlike other devices on the market, they provide partial innervation by stimulating different anatomical areas and are not manufactured to the same quality and safety standards as tVNS®. Non-Surgical Clinical Approach tVNS® provides the clinical effectiveness of vagus nerve stimulation without the risks and operational difficulties associated with surgical interventions. In this way, patients can benefit from significant therapeutic benefits in a non-invasive way and under their own application control. Minimal Side Effects The process of moving away from pharmacological treatments often goes hand in hand with the search for fewer side effects. tVNS®, a drug-free method, offers a safer treatment alternative by reducing the risk of long-term adverse effects. German Engineering and Production Quality Our commitment to excellence ensures that every tVNS® device meets the highest standards for quality and performance. Our devices are developed with durability and innovative design in mind, reflecting Germany's long-established engineering and manufacturing precision. With tVNS®, you invest in a technology focused on clinical success, trusted by healthcare professionals and researchers worldwide. Mobile App-Supported Therapy Experience Tracking and understanding your treatment progress is critical to clinical success. The tVNS® Patient mobile application developed for this purpose not only provides real-time monitoring but also enables seamless sharing of data with healthcare professionals. Access from Anywhere In today's world, remote access is of great importance for patient comfort. In response to this need, tVNS® offers a combination of device delivery directly to the patient's address and distance learning support. In this way, patients can easily begin their treatment process without the necessity of travel or logistical restrictions. Pediatric Compatibility tVNS® has been rigorously designed and approved for use in children. In this way, it fills an important gap in pediatric treatment in a safe and effective manner. Easy to Use Functionality should not compromise on simplicity. Standing out with its advanced technology, the tVNS® device is also as user-friendly as a smartphone and can be effortlessly integrated into your daily routine. tVNS® treatment stands out for its ease of use and integration into daily life . At the heart of this method is the principle of neurostimulation, which utilizes the vagus nerve's ability to influence various bodily functions and systems. tVNS® stimulates the auricular branch of the vagus nerve (ABVN) with gentle electrical impulses delivered through the skin. These impulses generate therapeutic signals that are transmitted first to the brainstem and then to higher centers, aiming to alleviate disorders within the nervous system. The device is designed with a completely patient-centered approach: easy to use, portable, and discreet. This allows you to integrate treatment sessions into your schedule without disrupting your daily routine. Whether you're at home, at work, or traveling, tVNS® offers a consistent and accessible solution for managing the symptoms of neurological disorders, including reducing seizure frequency in epilepsy. Each session with the tVNS® device is a step toward rebalancing the nervous system. This method uses the body's natural pathways to support healing and symptom relief. The device's ease of use makes starting and maintaining treatment extremely convenient. This empowers users to take control of their health through a non-invasive and effective method. Mechanism of Action of tVNS® Therapy tVNS® is designed to be portable and easy for patients to use at any time of the day and in any environment they choose. tVNS® Clinical Research and Patient Tracking Application Two Apps Integrated with Your tVNS® R Device: tVNS® Research and tVNS® Patient Your tVNS® R device provides access to two applications developed for research and patient monitoring: tVNS® Research and tVNS® Patient. The tVNS® Research app allows all technical parameters to be easily reprogrammed and transmitted wirelessly to the device. This gives researchers the flexibility to experiment with entirely new stimulation protocols. Technical and patient data can also be collected and securely stored through the app. The tVNS® Patient app automatically records all stimulation data (application time, duration, parameters, etc.). Additionally, it offers a structured survey module where patients can provide feedback on their experience. The tVNS® Patient app is fully compliant with the General Data Protection Regulation (GDPR). This means patient data is processed and stored in accordance with the highest confidentiality and security standards. tVNS® Technology Supported by Clinical Research Multi-center clinical studies and scientific research demonstrate the proven efficacy and safety of tVNS®. Thanks to our unique stimulation approach focused on the cymba concha region, our high quality standards, and our strong clinical data base, tVNS® has become a preferred neurotherapeutic solution for researchers. This holistic approach positions tVNS® at the forefront of innovation and patient-centered care in the field of neuromodulation. Epilepsy After 20 weeks of treatment, patients receiving active tVNS® had an average 34.2% reduction in seizure frequency. Prader-Willi-Syndrome After 12 months of treatment, 80% of patients treated with tVNS® had an average 50% reduction in the number of daily seizures/attacks compared to pre-treatment levels. Depression tVNS® administration, when used in conjunction with psychopharmacological treatment and psychotherapy, resulted in a reduction of at least 2–3 points in depression-specific HAMD scores in adult patients after a 9-week period. Migraine tVNS® treatment resulted in a 50% reduction in the frequency of migraine days after 12 weeks of treatment. Click for more information and clinical studies about the tVNS® Research device. tVNS® Research devices Clinical Research Enter a New Era in Patient Treatment with tVNS® Discover how tVNS® can transform your treatment approach. Incorporate this innovative solution into your practice, offering a safe and non-invasive way to heal your patients who haven't seen satisfactory results with conventional treatment methods. Let's take a step together to pioneer an innovative and people-centered approach to healthcare. Contact our expert experts to learn more about how you can integrate tVNS® into your clinical practice and the benefits it can provide for your patients. Together, let's pave the way for a healthier future and a higher quality of life. Contact us

PATIENT DECLARATION FORM CLINICAL DIAGNOSIS & HEALTH CONDITIONS Please click the button to download the guide: Download document

FAQs Frequently Asked Questions Am I suitable for treatment with tVNS®? 1 tVNS® is a non-invasive device used in the treatment of sympathetic vagal imbalances. It can be used in patients of all ages from 3 years of age. It can be used at any age from newborns with the approval of the doctor. In general, whether you are suitable for treatment is a decision that you will make in consultation with your doctor. If your doctor does not recommend or does not know the treatment, you can contact us. We can contact your doctor . What does it mean for the tvNS® device to be medically approved? 2 The manufacturer of the tVNS® therapy device, Germany-based tVNS Tehnologies GmbH, was established in Germany in 2003 and, as the world's pioneer of this technology, manages the worldwide clinical research and operations of the devices that have received the first medical approval in the world since 2010. With the medical approvals received in 2021 and 2023, it is the only auricular stimulation device that can safely apply vagus nerve treatment and is produced with the latest engineering technologies with the R&D and production team in Erlangen, Germany. Stimulation of the vagus nerve with devices that do not have safety and medical approval can lead to very serious consequences ranging from respiratory to cardiac arrest. Do I need to consult my doctor or device manufacturer for device settings when starting to use tVNS®? 3 No. tVNS® is very easy to use. It can be easily adjusted without the support of a doctor with the device training and instructions for use. When you receive the device, approximately 2 hours of device usage training is given. Afterwards, all settings related to the device are made by Turkey with a remote Bluetooth-supported application. Your therapy protocol is shared with your doctor on a regular basis. How often do I need to use tVNS®? 4 Therapy with tVNS® requires a total of 2 to 4 hours of sessions per day, depending on the indication used. The duration of these sessions can be planned as 1.5 hours. The time at which it will be is determined according to both the indication used and the daily routines and needs of the patient. What side effects might I experience? 5 Therapy with tVNS® is a treatment with very few side effects. In general, two types of side effects are observed. The first of these is local side effects that may occur in the form of itching, redness and pressure sores in the area where the outer auricle is stimulated. On the other hand, since the stimulation of the vagus nerve can affect the autonomic nervous system, systemic side effects may occur. These may include headache, nausea, or dizziness. As with other drug or neurostimulation treatments, an increase in seizures may occur. However, it differs from other treatments in that the side effects usually disappear soon after the end of treatment. Can I avoid taking medication if I choose tvNS ® treatment? 6 tVNS® therapy is an adjunct to medication, if you decide to stop or reduce your medication you should discuss this with your doctor. In general, it is not recommended to start a new drug, increase or decrease the dose, or start it simultaneously with another treatment at the time of initiation of treatment. In this way, we can observe the effects of tVNS® more objectively. How long will I need to use tVNS® treatment and how long will it take for the treatment to work? 7 tVNS® treatment is not an acute treatment, there is no external drug intake. It provides a long-term treatment option by stimulating certain centers of the brain and increasing the release of neurotransmitters over time, eliminating the sympathovagal imbalance. Like most drugs and neuromodulatory therapies for epilepsy treatment, tVNS® therapy is a long-term therapy. Even if you do respond to treatment with tVNS®, the effect usually starts with a delay of just a few weeks to months. Can tVNS ® be used by children? 8 tVNS® can be safely used by children under parental supervision. It was applied to two different 8 and 9 months old babies with the approval of a doctor in Turkey and no negative results were encountered. If it will be used with children, the sessions must be given under parental supervision. tVNS® can be used by children 6 years and older. If it is to be used in children younger than 6 years old, the sessions must be performed under the supervision of the parents. How can I access tvNS ® ? 9 If deemed appropriate by your doctor for the treatment of tVNS®, you can apply to our center and obtain the device. After planning how to use the device and the treatment protocol, you can start the treatment by receiving remote treatment support. 1 0 What are the approved indications of the device? Indicated since 2021 for Anxiety, Migraine, Autism, Cognitive Impairment, Depression, Fibromyalgia, Epilepsy, Inflammation, Prader-Willi Syndrome, Sleep Disorders, Stroke, Tinnitus, Asthma, Crohn's Disease, Atrial Fibrillation and Parkinson's. Apart from this, researches continue on different subjects such as neural plasticity, coma and diabetes. To what extent does tVNS ® treatment affect epileptic seizures? 11 According to clinical studies conducted in 2000 patients using the tVNS® device between 2010 and 2018, a significant reduction in the severity and number of seizures was observed in an average of 60% of the patients. It can be said that a secondary effect, which is widely seen, is an increase in vitality, cognitive progress and improvement in sleep patterns. It can completely stop seizures in 10-20% of patients. What are the indications (effects) of the t-VNS ® device? 12 1) It undertakes the task of increasing the activity of the parasympathetic nervous system (resting mode). 2) It provides the balance of neurotransmitter hormone that the body cannot produce enough. 3) It helps to increase brain plasticity (Neural plasticity /: the ability of the brain to undergo structural or physiological changes) in the medium and long term. 4) Reducing inflammation. In recent years, clinical studies of tVNS® have proven the inflammatory effects of nerve stimulation. Inflammation (colloquially known as inflammation/inflammation) in the simplest terms, against all kinds of foreign factors or internal-external tissue damage of living tissue; cellular (cellular), body fluid (humoral) or veins (vascular) are some series of reactions on the basis. By developing inflammation, the body actually aims to destroy the disease factor, to isolate the factors that it cannot destroy from healthy tissues or to eliminate damaged tissues. It is divided into acute and chronic inflammation. Examples of acute inflammation: Redness, swelling, fever, pain, edema, increased temperature Examples of chronic inflammation: Cancer, ALS, heart diseases, diabetes, hypertension, asthma, depression, neurological diseases Is the response time of vagal stimulation therapy (vagus nerve stimulation) the same in patients of all ages? 13 It has been observed that the earlier the patient starts vagal nerve stimulation therapy or the shorter the epilepsy history, the shorter the response time to the disease. For example, a 40-year-old epilepsy patient may take longer to respond to vagal nerve stimulation treatment than a pediatric epilepsy patient. Is nonsurgical tVNS (through the skin) vagus nerve stimulation) only a preliminary step for patients responding to surgical VNS therapy? Should epilepsy patients who respond to cutaneous vagus stimulation therapy switch to invasive therapy? 14 tVNS® therapy may be a preliminary step for invasive vagal nerve stimulation requiring surgical intervention, but it is also an alternative treatment modality. The reasons for this are; I. Not every patient is suitable for invasive intervention. II. In case of failure to respond to treatment, removal of the electrode is difficult and risky, as the tissues of the vagus nerve wrap and fuse with the electrode. Even if the battery is removed, the patient will have to live with an inactive implant electrode in his body for life. It may cause pain or pressure, and infection may develop over time. Can the transcutaneous (through the skin conduction/non-invasive) method and the Invasive (surgical implant) method give the same effect in vagal nerve stimulation? 15 According to fMRI studies, it has been proven that both methods stimulate the same points in the brain. However, tVNS® has some advantages over the invasive method: 1. Contrary to the invasive alternative, since it has a rechargeable battery, it can give electrical stimulation as more frequent and intense programs. 2. As with the invasive alternative, high currents up to 5MA can be given, as it does not directly give the electric current attached to the nerve and does not pose the risk of nerve damage. Why does not every patient respond to his treatment in the same way or at the same rate? 16 There are different hypotheses about this, one of them is myelin thickness. Thick myelin nerves conduct electrical conduction better, and in this way vagus nerve stimulation can be done more effectively. Myelin thickness can vary from person to person genetically. Studies have shown that patients with thick myelin nerves respond better to treatment. What is the direct current (milliamps) to stimulate the ear? 17 There are scientifically proven studies on this subject. The minimum electrical current required to stimulate the vagus nerve is kept somewhat below the pain/pain threshold so that it does not activate the pain nerves. For this reason, there should be no pain or pain during stimulation, but a distinct vibration sensation. This is the most optimal stimulation intensity and should be at a level that does not disturb the patient. In which situations can the device not be used during the day? 18 You can safely use the tVNS® device while mobile, while walking, watching TV, reading a book, or at the computer. For safety reasons, it is recommended not to be used while driving to avoid distractions. It is recommended that the device be turned off when passing near high magnetic fields and devices that create high magnetic fields. Apart from this, it can be used in children both while they are asleep and awake. Adults are advised not to sleep while performing self-therapy. In order to avoid the risk of any cable entanglement around the neck, our children can be given therapy both while awake and asleep under parental supervision. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Cognitive Impairment Groundbreaking Technologies for Life There is no drug therapy approved to treat cognitive impairment. Medicines used to treat symptoms of Alzheimer's disease have been tried. Some studies have found that using these drugs for cognitive impairment is helpful, while others have concluded that there is no benefit. It has been noted that the use of other drugs, including NSAIDs, Ginkgo, Biloba and vitamin E, does not provide a great benefit. tVNS Effect Mechanism There are many clinical studies in recent years that cognitive disorders are caused by inflammation in the brain. Although the basic efficacy mechanism of tVNS has not been fully resolved, our new generation devices in 2021 became the first neuromodulation therapy approved for cognitive impairment in the world, due to both its benefits in the treatment of inflammation and the increase in neuroplasticity. Types of Cognitive Disorder Dementia It is the inadequacies experienced in language, skills and orientation, especially forgetfulness. Dementia is a family that includes many different types. There are Alzheimer's, dementia due to chronic cerebrovascular disease, alcoholic dementia, depressive dementia, dementia due to infections, etc. Dementia occurs as a result of general deterioration of the upper level functions of the cerebral cortex, especially over 75 years of age, with advancing age. Treatment Options for Cognitive Disorder Improving memory and attention processes by increasing prefrontal cortex and hippocampal activity Increasing attention and alertness via the noradrenergic system Protecting nerve cells with anti-inflammatory effects (neuroprotection) Reducing stress-induced cognitive impairment by increasing parasympathetic activity Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Findings from Neuroimaging Studies Hafıza ve Öğrenmede Artış MCI ve Demans Riski Altındaki Bireylerde Potansiyel Faydalar fMRI Bulguları ile Desteklenen Beyin Aktivitesi Artışı What is Cognitive Impairment? The shrinkage caused by the loss of cells in the brain causes various functional disorders. These dysfunctions may manifest as dementia, Alzheimer, and mild cognitive impairment, which are common in people ives. People with cognitive impairment are at high risk for Alzheimer and dementia. When adequate precautions are taken, cognitive impairment may regress, and it is possible for these people to lead a normal life. Targeted Cognitive Benefits with tVNS® Memory Improvement in short-term and long-term memory Attention Increased attention and concentration Learning Increased capacity to learn new information Cognitive development Improvement in mental flexibility and decision-making processes Focusing Reduction of stress-induced cognitive clouding These effects make tVNS a valuable supportive tool, especially for older adults, those with post-traumatic cognitive impairment, those with post-depressive cognitive decline, and individuals diagnosed with MCI. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home Hasta tarafından günlük olarak, kendi ev ortamında kolaylıkla kullanılabilir. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Uyarım parametreleri hastaya özel olarak ayarlanabilir. Contact us Contact us

Vagus nerve stimulation for depression DEPRESSION Groundbreaking Technologies for Life What is Depression? Depression is a mood disorder that causes constant sadness and loss of interest. Depression is also called major depressive disorder or clinical depression. The feelings, thoughts and behaviors of individuals suffering from this condition are affected and various emotional or physical problems may arise due to this. There may be problems doing normal daily activities, and sometimes life may seem not worth living. Depression is not just a feeling of malaise or momentary weakness. Depression is also not such a simple problem that it can be solved in an instant. Depression is a treatable medical condition that requires treatment. This treatment process may take a long time in some cases. Everyone goes through periods of not feeling well emotionally and psychologically from time to time. These periods generally last for a certain period of time, depending on the intensity of the troubles and sorrows you experience. However, if your bad periods last longer than two or three weeks and prevent you from doing many of the things you do in your daily life properly; this condition is called depression (major depressive disorder). Targeted Benefits in the Treatment of Depression with tVNS® Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Why Are Alternative Treatment Options Needed? Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Meet tVNS®: A New Approach to Depression Through the Vagus Nerve Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. " The scientific solution for depression: tVNS®. The life of a 17-year-old girl diagnosed with medication-resistant, suicidal depression was completely changed by transcutaneous vagus nerve stimulation. This clinically proven, non-invasive method is especially promising for young individuals. It enables the safe management of depression by affecting the brain's mood centers via the vagus nerve. Key Features of tVNS®: Clinically proven effectiveness, non-invasive and drug-free therapy, the ability to monitor your recovery process, and suitability for pediatric use. " Who is it suitable for? tVNS® can be a complementary solution in the following situations: Individuals experiencing mild, moderate and severe depression Those who do not benefit sufficiently from drug treatment Those seeking alternatives due to drug side effects Those who experience depression along with anxiety and sleep disturbances What is Depression? What is Depression? Depression is a mood disorder that causes constant sadness and loss of interest. Depression is also called major depressive disorder or clinical depression. The feelings, thoughts and behaviors of individuals suffering from this condition are affected and various emotional or physical problems may arise due to this. There may be problems doing normal daily activities, and sometimes life may seem not worth living. Depression is not just a feeling of malaise or momentary weakness. Depression is also not such a simple problem that it can be solved in an instant. Depression is a treatable medical condition that requires treatment. This treatment process may take a long time in some cases. Everyone goes through periods of not feeling well emotionally and psychologically from time to time. These periods generally last for a certain period of time, depending on the intensity of the troubles and sorrows you experience. However, if your bad periods last longer than two or three weeks and prevent you from doing many of the things you do in your daily life properly; this condition is called depression (major depressive disorder). Adolescence is a critical period when depression most frequently begins and treatment-resistant cases are observed. Safe and non-invasive options are needed for adolescents who fail to respond to traditional treatments. Transcutaneous auricular vagus nerve stimulation (taVNS) is a new method that can be applied without the need for surgery by stimulating the vagus nerve through the ear. In this study, a 17-year-old girl with treatment-resistant depression received taVNS treatment for 7.5 months, with daily sessions at home, in conjunction with escitalopram therapy, and under regular monitoring by the clinical team. A total of over 270 sessions were administered, with an average daily use of approximately 3 hours. Aside from mild skin irritation, no serious side effects were observed, and cardiac safety tests were normal. Depression severity decreased during treatment, both as assessed by self-report and clinician assessments. The patient completed high school and entered university, and partial improvements in functioning were noted. The results suggest that taVNS is a feasible, safe, and promising complementary treatment option for adolescents. Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. Types of Depression Symptoms Types of Depression The symptoms caused by major depression are different for each individual. Medical professionals look for various markers or traits that clarify an individual's type of depression. A marker or feature may indicate the presence of a particular type of depression: Anxiety distress : Unusual restlessness or depression with worry about possible events or loss of control. Atypical features : Depression with temporary happiness from certain events, increased appetite, excessive need for sleep, hypersensitivity to rejection, and a feeling of heaviness in the organs. WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us Contact us

tVNS Vagus Stimulation Devices Information Request Form Name Surname Your E-mail Address Phone Number Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible. Home Page