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tVNS® Vagus Stimulasyon Cihazları ile ilgili ihtiyacınız olan bilgilendirme ve yönlendirmelerin olduğu içerik portali You can access the content portal, which contains the information and guidance you need regarding t VNS® Vagus Stimulation Devices, using the links below. If you are an individual tVNS user, please click on the "tVNS User Portal" link for your training and support needs. If you are a physician working on clinical research and different indication applications with our tVNS devices , please click on the "tVNS Clinical Portal" link. Welcome to tVNS Portal tVNS User Portal tVNS Clinic Portal

FAQs Frequently Asked Questions Am I suitable for treatment with tVNS®? 1 tVNS® is a non-invasive device used in the treatment of sympathetic vagal imbalances. It can be used in patients of all ages from 3 years of age. It can be used at any age from newborns with the approval of the doctor. In general, whether you are suitable for treatment is a decision that you will make in consultation with your doctor. If your doctor does not recommend or does not know the treatment, you can contact us. We can contact your doctor . What does it mean for the tvNS® device to be medically approved? 2 The manufacturer of the tVNS® therapy device, Germany-based tVNS Tehnologies GmbH, was established in Germany in 2003 and, as the world's pioneer of this technology, manages the worldwide clinical research and operations of the devices that have received the first medical approval in the world since 2010. With the medical approvals received in 2021 and 2023, it is the only auricular stimulation device that can safely apply vagus nerve treatment and is produced with the latest engineering technologies with the R&D and production team in Erlangen, Germany. Stimulation of the vagus nerve with devices that do not have safety and medical approval can lead to very serious consequences ranging from respiratory to cardiac arrest. Do I need to consult my doctor or device manufacturer for device settings when starting to use tVNS®? 3 No. tVNS® is very easy to use. It can be easily adjusted without the support of a doctor with the device training and instructions for use. When you receive the device, approximately 2 hours of device usage training is given. Afterwards, all settings related to the device are made by Turkey with a remote Bluetooth-supported application. Your therapy protocol is shared with your doctor on a regular basis. How often do I need to use tVNS®? 4 Therapy with tVNS® requires a total of 2 to 4 hours of sessions per day, depending on the indication used. The duration of these sessions can be planned as 1.5 hours. The time at which it will be is determined according to both the indication used and the daily routines and needs of the patient. What side effects might I experience? 5 Therapy with tVNS® is a treatment with very few side effects. In general, two types of side effects are observed. The first of these is local side effects that may occur in the form of itching, redness and pressure sores in the area where the outer auricle is stimulated. On the other hand, since the stimulation of the vagus nerve can affect the autonomic nervous system, systemic side effects may occur. These may include headache, nausea, or dizziness. As with other drug or neurostimulation treatments, an increase in seizures may occur. However, it differs from other treatments in that the side effects usually disappear soon after the end of treatment. Can I avoid taking medication if I choose tvNS ® treatment? 6 tVNS® therapy is an adjunct to medication, if you decide to stop or reduce your medication you should discuss this with your doctor. In general, it is not recommended to start a new drug, increase or decrease the dose, or start it simultaneously with another treatment at the time of initiation of treatment. In this way, we can observe the effects of tVNS® more objectively. How long will I need to use tVNS® treatment and how long will it take for the treatment to work? 7 tVNS® treatment is not an acute treatment, there is no external drug intake. It provides a long-term treatment option by stimulating certain centers of the brain and increasing the release of neurotransmitters over time, eliminating the sympathovagal imbalance. Like most drugs and neuromodulatory therapies for epilepsy treatment, tVNS® therapy is a long-term therapy. Even if you do respond to treatment with tVNS®, the effect usually starts with a delay of just a few weeks to months. Can tVNS ® be used by children? 8 tVNS® can be safely used by children under parental supervision. It was applied to two different 8 and 9 months old babies with the approval of a doctor in Turkey and no negative results were encountered. If it will be used with children, the sessions must be given under parental supervision. tVNS® can be used by children 6 years and older. If it is to be used in children younger than 6 years old, the sessions must be performed under the supervision of the parents. How can I access tvNS ® ? 9 If deemed appropriate by your doctor for the treatment of tVNS®, you can apply to our center and obtain the device. After planning how to use the device and the treatment protocol, you can start the treatment by receiving remote treatment support. 1 0 What are the approved indications of the device? Indicated since 2021 for Anxiety, Migraine, Autism, Cognitive Impairment, Depression, Fibromyalgia, Epilepsy, Inflammation, Prader-Willi Syndrome, Sleep Disorders, Stroke, Tinnitus, Asthma, Crohn's Disease, Atrial Fibrillation and Parkinson's. Apart from this, researches continue on different subjects such as neural plasticity, coma and diabetes. To what extent does tVNS ® treatment affect epileptic seizures? 11 According to clinical studies conducted in 2000 patients using the tVNS® device between 2010 and 2018, a significant reduction in the severity and number of seizures was observed in an average of 60% of the patients. It can be said that a secondary effect, which is widely seen, is an increase in vitality, cognitive progress and improvement in sleep patterns. It can completely stop seizures in 10-20% of patients. What are the indications (effects) of the t-VNS ® device? 12 1) It undertakes the task of increasing the activity of the parasympathetic nervous system (resting mode). 2) It provides the balance of neurotransmitter hormone that the body cannot produce enough. 3) It helps to increase brain plasticity (Neural plasticity /: the ability of the brain to undergo structural or physiological changes) in the medium and long term. 4) Reducing inflammation. In recent years, clinical studies of tVNS® have proven the inflammatory effects of nerve stimulation. Inflammation (colloquially known as inflammation/inflammation) in the simplest terms, against all kinds of foreign factors or internal-external tissue damage of living tissue; cellular (cellular), body fluid (humoral) or veins (vascular) are some series of reactions on the basis. By developing inflammation, the body actually aims to destroy the disease factor, to isolate the factors that it cannot destroy from healthy tissues or to eliminate damaged tissues. It is divided into acute and chronic inflammation. Examples of acute inflammation: Redness, swelling, fever, pain, edema, increased temperature Examples of chronic inflammation: Cancer, ALS, heart diseases, diabetes, hypertension, asthma, depression, neurological diseases Is the response time of vagal stimulation therapy (vagus nerve stimulation) the same in patients of all ages? 13 It has been observed that the earlier the patient starts vagal nerve stimulation therapy or the shorter the epilepsy history, the shorter the response time to the disease. For example, a 40-year-old epilepsy patient may take longer to respond to vagal nerve stimulation treatment than a pediatric epilepsy patient. Is nonsurgical tVNS (through the skin) vagus nerve stimulation) only a preliminary step for patients responding to surgical VNS therapy? Should epilepsy patients who respond to cutaneous vagus stimulation therapy switch to invasive therapy? 14 tVNS® therapy may be a preliminary step for invasive vagal nerve stimulation requiring surgical intervention, but it is also an alternative treatment modality. The reasons for this are; I. Not every patient is suitable for invasive intervention. II. In case of failure to respond to treatment, removal of the electrode is difficult and risky, as the tissues of the vagus nerve wrap and fuse with the electrode. Even if the battery is removed, the patient will have to live with an inactive implant electrode in his body for life. It may cause pain or pressure, and infection may develop over time. Can the transcutaneous (through the skin conduction/non-invasive) method and the Invasive (surgical implant) method give the same effect in vagal nerve stimulation? 15 According to fMRI studies, it has been proven that both methods stimulate the same points in the brain. However, tVNS® has some advantages over the invasive method: 1. Contrary to the invasive alternative, since it has a rechargeable battery, it can give electrical stimulation as more frequent and intense programs. 2. As with the invasive alternative, high currents up to 5MA can be given, as it does not directly give the electric current attached to the nerve and does not pose the risk of nerve damage. Why does not every patient respond to his treatment in the same way or at the same rate? 16 There are different hypotheses about this, one of them is myelin thickness. Thick myelin nerves conduct electrical conduction better, and in this way vagus nerve stimulation can be done more effectively. Myelin thickness can vary from person to person genetically. Studies have shown that patients with thick myelin nerves respond better to treatment. What is the direct current (milliamps) to stimulate the ear? 17 There are scientifically proven studies on this subject. The minimum electrical current required to stimulate the vagus nerve is kept somewhat below the pain/pain threshold so that it does not activate the pain nerves. For this reason, there should be no pain or pain during stimulation, but a distinct vibration sensation. This is the most optimal stimulation intensity and should be at a level that does not disturb the patient. In which situations can the device not be used during the day? 18 You can safely use the tVNS® device while mobile, while walking, watching TV, reading a book, or at the computer. For safety reasons, it is recommended not to be used while driving to avoid distractions. It is recommended that the device be turned off when passing near high magnetic fields and devices that create high magnetic fields. Apart from this, it can be used in children both while they are asleep and awake. Adults are advised not to sleep while performing self-therapy. In order to avoid the risk of any cable entanglement around the neck, our children can be given therapy both while awake and asleep under parental supervision. Contact us

DEPRESSION Groundbreaking Technologies for Life " The scientific solution for depression: tVNS®. The life of a 17-year-old girl diagnosed with medication-resistant, suicidal depression was completely changed by transcutaneous vagus nerve stimulation. This clinically proven, non-invasive method is especially promising for young individuals. It enables the safe management of depression by affecting the brain's mood centers via the vagus nerve. Key Features of tVNS®: Clinically proven effectiveness, non-invasive and drug-free therapy, the ability to monitor your recovery process, and suitability for pediatric use. " What is Depression? Depression is a mood disorder that causes constant sadness and loss of interest. Depression is also called major depressive disorder or clinical depression. The feelings, thoughts and behaviors of individuals suffering from this condition are affected and various emotional or physical problems may arise due to this. There may be problems doing normal daily activities, and sometimes life may seem not worth living. Depression is not just a feeling of malaise or momentary weakness. Depression is also not such a simple problem that it can be solved in an instant. Depression is a treatable medical condition that requires treatment. This treatment process may take a long time in some cases. Everyone goes through periods of not feeling well emotionally and psychologically from time to time. These periods generally last for a certain period of time, depending on the intensity of the troubles and sorrows you experience. However, if your bad periods last longer than two or three weeks and prevent you from doing many of the things you do in your daily life properly; this condition is called depression (major depressive disorder). SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Depression The symptoms caused by major depression are different for each individual. Medical professionals look for various markers or traits that clarify an individual's type of depression. A marker or feature may indicate the presence of a particular type of depression: Anxiety distress : Unusual restlessness or depression with worry about possible events or loss of control. Atypical features : Depression with temporary happiness from certain events, increased appetite, excessive need for sleep, hypersensitivity to rejection, and a feeling of heaviness in the organs. Mixed features : High self-esteem, and energetic mania concurrent with depression involving too much talk Catatonia : Depression with uncontrollable motor activity and purposeless movements or with fixed and rigid postures. Melancholic features : Depression, which is seen as a cooling reaction to something that once brought pleasure, depression that may be accompanied by worsening mood, weakness or agitation during waking up early in the morning. Seasonal features : Depression triggered by seasonal changes and less exposure to sunlight. Peripartum onset : depression that occurs during pregnancy or in the weeks or months after birth, that is, in the "postpartum" period Psychotic features : depression accompanied by personal inadequacy or other negative delusions or hallucinations Treatment Options for Depression Drug Therapy The medications to be used during depression treatment should be determined under the supervision of a doctor. More information Hospital Treatment In some cases of severe depression, hospitalization is necessary. This may be necessary if the individual is unable to care for themselves properly or is in danger of harming themselves or others. More information Psychotherapy It is a general term used for an individual pursuing treatment for depression by talking with a mental health professional about their condition and related issues. More information Transcutaneous Vagus Nerve Stimulation (tVNS) Increased parasympathetic activity promotes relaxation and well-being. Increased serotonin release also boosts mood. More information WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

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tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır insomnia Symptoms, Causes and Diagnostic Methods Insomnia Symptoms Difficulty falling asleep, waking up before expected, Not feeling fresh after sleep, Being angry and aggressive, Feeling tired and sluggish during the day, Difficulty with coordination and focus, Having difficulty remembering events, Being sleepy during the day, Worrying about sleep, Increase in the number of errors and accidents, Hyperactivity, Mood disorders, Anxiety and depression. Causes of Insomnia Stress Environmental disturbances (noise, light, or extreme heat/cold) Disruption of normal sleep patterns (Travel or a newborn baby) Jetlag after travel Medication use for various ailments The cause of the emergence of chronic insomnia. Unlike acute insomnia chronic diseases can also cause mental tension. Asthma chronic body aches heart palpitations chronic stress Depression drug use emotional or physical discomfort Thyroid diseases psychological reasons Insomnia Diagnostic Methods He or she may perform a physical exam to look for signs of medical problems that may be related to insomnia. While investigating the underlying physical diseases that may cause insomnia, it is also investigated whether there is a problem with the thyroid. If deemed necessary, reports of high-resolution imaging methods such as MRI may be requested. For a definitive diagnosis of insomnia, the doctor may request a chart of one or two weeks of sleep patterns or an overnight follow-up at the patient's sleep clinic. Thus, how long you stay awake at night, breathing movements, brain waves and body activities can be monitored and recorded. People with Insomnia Researchers state that 30% to 40% of adults try to cope with insomnia every year. According to the National Sleep Epidemiology Survey (TAPES) in Adults in Turkey, the incidence of insomnia is 15% (Male: 10.5%, Female: 20.2%). Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır MIGRAINE What is Migraine? It is a neurological disorder that causes a throbbing, severe headache, often felt intensely on one side of the head. The distinctive features of migraine that distinguish it from other headaches include nausea and vomiting, and sensitivity to sound and light. The pain is so severe that it interferes with the completion of daily activities and leads to limitation. Migraine attacks take the first place among the most important causes of disability and loss of work in developed countries. Many migraine attacks are seen as a type of "migraine without aura". Other conditions accompanying the headache of migraine patients without aura; nausea, vomiting, sensitivity to light, sound and smell. Migraine patients with aura, on the other hand, may experience "aura" attacks ranging from 5 minutes to 60 minutes before the headache attacks begin. What is Migraine? It is a neurological disorder that causes a throbbing, severe headache, often felt intensely on one side of the head. The distinctive features of migraine that distinguish it from other headaches include nausea and vomiting, and sensitivity to sound and light. The pain is so severe that it interferes with the completion of daily activities and leads to limitation. Migraine attacks take the first place among the most important causes of disability and loss of work in developed countries. Many migraine attacks are seen as a type of "migraine without aura". Other conditions accompanying the headache of migraine patients without aura; nausea, vomiting, sensitivity to light, sound and smell. Migraine patients with aura, on the other hand, may experience "aura" attacks ranging from 5 minutes to 60 minutes before the headache attacks begin. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Benefits of tVNS® in Migraine Treatment Decrease in the frequency of migraine attacks Reduction of stress-induced migraine triggers Decrease in duration and severity of attacks Decreased need for medication Better quality of life between attacks In a 2015 study, Straube et al. investigated the effectiveness of auricular vagus nerve stimulation (VNS) in migraine prophylaxis. Patients received low-frequency electrical stimulation four times a week, each lasting one hour. A total of 46 patients with chronic migraine participated in this randomized, double-blind, sham-controlled study. Participants were assigned to either the active vagus nerve stimulation or sham stimulation groups. At the end of the four-week treatment period, a significant reduction in migraine days was observed in the active stimulation group, and this effect was more pronounced than in the sham group. Differences in pain intensity and medication use were also found in favor of the active treatment. The study demonstrated that auricular vagus nerve stimulation may be an effective and well-tolerated approach for chronic migraine prophylaxis. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us Contact us

tVNS klinik araştırma cihazları ile ilgili bilgileri içerir tVNS® R T ranscutaneous Vagus Nerve Stimulati on ( tVNS®) Research Device Full Wireless Parameter Programmability Patient App for Data Collection Support for Clinical Trials Triggered tVNS® Legacy and Hook Electrode Sham Stimulatio n What's in the Box? Your tVNS® R device comes with a starter pack that includes everything you need to start using your tVNS® device. We also offer special electrodes for sham stimulation or fMRI use for sale. Please contact us to order specialized accessories. tVNS® L stimulation device Ear electrode with cable clip Carrying case Charger Electrode pads Electrode contact cream Travel jar for electrode cream Access to tVNS® app Instructions for Use Research and Patient App Your tVNS® R device gives you access to two apps: the tVNS® Research and tVNS® Patient app. All technical parameters can easily be reprogrammed and wirelessly transmitted with the tVNS® Research app, allowing the researcher to try completely new stimulation protocols. In addition, you can collect and store technical and patient data. The tVNS® Patient app automatically stores all technical data (stimulation parameters, time and duration of the stimulation etc.) and offers a questionnaire for patient feedback. Research and Patient Application Support for Clinical Research Support for Clinical Trials We offer an individual adaptation of all parts for certain studies, e.g by changing the questionnaire in order to allow better feedback from the patient, or through the implementation of special stimulation parameters or technical ideas. The tVNS® R device is defined as a device for investigational use. We can provide a CB report that proves the safety according to all medical device standards, in order to assist you with ethics approvals. So far, it has been accepted by all ethics committees. In addition, we offer an international expert network and can direct any questions to experienced people around the world. Triggered tVNS® We offer a separate PC-based tVNS® manager software. This software enables reaction to outside trigger signals (e.g. ECG R-wave trigger generated by an external ECG system, transferred to a PC). Thus, closed loop tVNS® or triggered tVNS® can be realized in a scientific setup. Triggered tVNS® Legacy and Hook Electrode Legacy and Hook Electrode We offer two different types of electrode designs with our tVNS® devices: The Hook Electrode (left) comes standard with all new tVNS® devices. It offers better fixation and usability during daily activities. The Legacy Electrode (right) can be used if the patient has small ears or a special ear shape. The integrated slider allows for better adaption to the ear. Sham Stimulation Sham Stimulation The well known sham stimulation at the ear lobe is still possible. Upon request, we support studies by providing other more sophisticated sham stimulation options.

tVNS Transkutanöz Vagus Sinir Stimülasyonu cihazıdır. Dirençli Epilepsi, Migren ve Depresyon Tedavisinde Ameliyatsız İlaçsız Kulaktan Vagus Sinirini Uyaran Dünyanın CE onaylı Tek Nöroterapi - vagus stimulasyonu- cihazıdır. tVNS Türkiye , "t-vnstherapy "tek yetkili satıcısıdır. The World Has Evolved, and So Have Therapies The World’s Only Medically Approved, Non-Surgical Vagus Nerve Therapy Registered in the Turkish Ministry of Health’s Product Tracking System (UTS) With 20 Years of Vagus Nerve Therapy Experience in Over 50 Countries, We Are Here to Help You Rediscover Quality of Life. tVNS® Patient Portal Healthcare Professionals To play, press and hold the enter key. To stop, release the enter key. Trusted Globally by Leading Institutions Trusted Innovation in Non-Invasive Neurological Treatment: tVNS® tVNS®, developed in Germany since 2003, is the first and only medically approved device in the world for non-invasive vagus nerve stimulation applied through the ear. tVNS®, which has the European Union CE-MDR Class IIa certification and the approval of the Ministry of Health of the Republic of Türkiye, is used safely by thousands of patients in more than 50 countries. Safe and Effective Approach to Treatment: Application that does not require surgical intervention Clinical efficacy supported by scientific studies Personalized protocols targeting sympathovagal balance Low side effect profile, high patient compliance tVNS® offers a modern and reliable solution for the management of neurological diseases. It has clinical and regulatory approvals for the restoration of sympathovagal balance in the following indications: Anxiety Migraine Autism Cognitive Impairment Depression Fibromyalgia E p ilepsy Inflammation Pr ader-Willi Syndrome Sleep Disorders Tinnitus Asthma Crohn's Disease Atrial Fibrillation Parkinson's Media Coverage of tVNS® To play, press and hold the enter key. To stop, release the enter key. Treatment Stories of tVNS® Patients My 7-year-old son with Dravet syndrome had seizure periods that required intensive care treatments every month. We have been using tVNS for 2 years, and we are happy to have a seizure-free life, obtain mental development, and reduction in autism symptoms. Zeliha KORKMAZ, Kayseri, Erciyes University Prof. Dr. Hakan GÜMÜŞ Get the tVNS® Patient App The tVNS® Patient app communicates with your tVNS® device using Bluetooth. This app allows you to keep an online diary of important health data (your patient's general mood and comfort, seizures if you have epilepsy, and important notes), compile your therapy history recorded on your device into a report, and share all records with your doctor with a single click. It allows you to monitor and make changes to your therapy from the comfort of your home, wherever you are in the world. tVNS® uses an ear electrode to deliver mild electrical impulses (neurostimulation) to the ear, activating specific nerve fibers and stimulating the auricular branch of the vagus nerve through the skin, sending nerve signals to the brainstem and higher centers. This alleviates symptoms of sympathovagal imbalance, such as reducing seizures in epilepsy. How tVNS® Works tVNS® CARE Therapy Tracking THE MOST EFFECTIVE WAY TO GET RESULTS FROM tVNS® In medical device treatments that can be applied at home without a doctor's supervision, the most important requirement for the success of the treatment is that a protocol specific to the patient's needs is prepared and that the patient is using the device correctly and is monitored by the doctor and a team of experts. The world-unique tVNS Care® Technology is a digital health service that can increase the success rate of treatment by up to 50%, where a patient-specific program is prepared by referencing the protocols of similar patients in more than 50 countries, and all details of the treatment can be monitored online by our expert teams. News from tVNS No posts published in this language yet Once posts are published, you’ll see them here. REFERENCES Contact us Name Surname Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Your E-mail Address Phone Number Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Cognitive Impairment Groundbreaking Technologies for Life There is no drug therapy approved to treat cognitive impairment. Medicines used to treat symptoms of Alzheimer's disease have been tried. Some studies have found that using these drugs for cognitive impairment is helpful, while others have concluded that there is no benefit. It has been noted that the use of other drugs, including NSAIDs, Ginkgo, Biloba and vitamin E, does not provide a great benefit. tVNS Effect Mechanism There are many clinical studies in recent years that cognitive disorders are caused by inflammation in the brain. Although the basic efficacy mechanism of tVNS has not been fully resolved, our new generation devices in 2021 became the first neuromodulation therapy approved for cognitive impairment in the world, due to both its benefits in the treatment of inflammation and the increase in neuroplasticity. Types of Cognitive Disorder Dementia It is the inadequacies experienced in language, skills and orientation, especially forgetfulness. Dementia is a family that includes many different types. There are Alzheimer's, dementia due to chronic cerebrovascular disease, alcoholic dementia, depressive dementia, dementia due to infections, etc. Dementia occurs as a result of general deterioration of the upper level functions of the cerebral cortex, especially over 75 years of age, with advancing age. Treatment Options for Cognitive Disorder Improving memory and attention processes by increasing prefrontal cortex and hippocampal activity Increasing attention and alertness via the noradrenergic system Protecting nerve cells with anti-inflammatory effects (neuroprotection) Reducing stress-induced cognitive impairment by increasing parasympathetic activity Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Findings from Neuroimaging Studies Increased Memory and Learning Potential Benefits for Individuals at Risk for MCI and Dementia Increased Brain Activity Supported by fMRI Findings What is Cognitive Impairment? The shrinkage caused by the loss of cells in the brain causes various functional disorders. These dysfunctions may manifest as dementia, Alzheimer, and mild cognitive impairment, which are common in people ives. People with cognitive impairment are at high risk for Alzheimer and dementia. When adequate precautions are taken, cognitive impairment may regress, and it is possible for these people to lead a normal life. Targeted Cognitive Benefits with tVNS® Memory Improvement in short-term and long-term memory Attention Increased attention and concentration Learning Increased capacity to learn new information Cognitive development Improvement in mental flexibility and decision-making processes Focusing Reduction of stress-induced cognitive clouding These effects make tVNS a valuable supportive tool, especially for older adults, those with post-traumatic cognitive impairment, those with post-depressive cognitive decline, and individuals diagnosed with MCI. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home Hasta tarafından günlük olarak, kendi ev ortamında kolaylıkla kullanılabilir. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Uyarım parametreleri hastaya özel olarak ayarlanabilir. Contact us Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır INSOMNIA (SLEEP DISORDER) Groundbreaking Technologies for Life What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Insomnia Acute insomnia : It refers to the short-term appearance of insomnia. Acute insomnia usually occurs after a stressful day or on days when mental tension is high. Our body clock has a har d time showing when it's time to rest on such difficult days. This irregularity, which usually lasts for 1 to 2 days, continues until we feel better. There are signs of acute insomnia that can last up to 4 weeks. Chronic insomnia: A sleep disorder that lasts for 1 month or more is called chronic insomnia. A large proportion of 10-15% of adults suffer from chronic in somnia. Compared to acute insomnia, chronic insomnia requires medical attention. The main cause of this type of disorder is usually the presence of major depression. Hypersomnia: characterized by excessive sleepiness and excessive daytime sleep requirements. It is less common than insomnia. Narcolepsy : Includes excessive daytime sleepiness and abnormal findings in daily REM sleep for at least 3 months. Narcolepsy is an abnormality in the sleep mechanism, especially in the REM mechanism. Treatment Options for Insomnia Sleep Techniques The flow of air in and out of the lungs during breathing Blood oxygen levels. Body position. More information CPAP Titration (Mask Therapy) In some cases of severe depression, hospitalization is necessary. This may be necessary if the individual is unable to care for themselves properly or is in danger of harming themselves or others. More information Polysomnography In other words, a sleep test is a procedure that uses devices to record sleep throughout the night to determine the quality of sleep and identify the cause of sleep disturbances. More information Transcutaneous Vagus Nerve Stimulation (tVNS) The vagus nerve facilitates communication between the gut and the brain. When you're unhappy, the vagus nerve senses that something is wrong and activates the sympathetic nervous system, a key component of the digestive system, which then releases cortisol. More information WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

Start a New Era in Clinical Practice with tVNS® A drug-free and non-surgical solution that improves your quality of life: tVNS® is a scientifically proven treatment that supports body balance by non-invasively stimulating the vagus nerve through the ear. This innovative system, which applies precise stimulation to the cymba concha region, offers personalized therapy with wireless parameter settings. Approved as a Class IIa medical device under the European Union Medical Devices Directive (EU-MDR), tVNS® meets the highest standards for safety and effectiveness. tVNS® R Transcutaneous Vagus Nerve Stimulation Device Full Wireless Parameter Programmability Patient Application for Data Collection Support for Clinical Research Triggered tVNS® Legacy and Hook Electrode Sham Stimulation Leading Healthcare Organizations Worldwide Trust tVNS® Devices To play, press and hold the enter key. To stop, release the enter key. Why Are We Pioneers in This Field with tVNS®? We Offer Reliable and Scientific Solutions with Over 20 Years of Experience For over twenty years, we have been pioneering the field with our innovative work in non-invasive vagus nerve stimulation. Our devices were developed in Germany using advanced technology, and their effectiveness has been validated through clinical studies. Approved as a Class IIa medical device under EU-MDR, tVNS® stands out in the clinical field not only for its effectiveness but also for its reliability and low side effect profile. In today's world, where scientifically unverified practices are becoming increasingly common, tVNS® offers an evidence-based and approved treatment method. Since we first introduced the Cerbomed Nemos® device, we have maintained our market leadership in vagus nerve technologies. tVNS® systems, preferred both clinically and in research, distinguish themselves with their safety, precision, and user-friendliness. Prioritizing patient comfort and long-term benefits, our devices are manufactured to the highest quality standards at our production center in Germany. Because we believe in the safe start of the healing process. What is tVNS®? Non-Invasive Vagus Nerve Stimulation in the Treatment of Neurological Diseases In cases where pharmacological or invasive treatment approaches are inadequate or cause undesirable side effects, tVNS® offers an effective and comfortable treatment option for patients. The vagus nerve, which plays a central role in our body's nervous system, is critical for maintaining internal balance (homeostasis). tVNS® (Transcutaneous Vagus Nerve Stimulation) harnesses the therapeutic potential of this nerve by targeting its auricular branch, which is accessible in the ear. This innovative method modulates vagus nerve activity with low-intensity electrical stimulation and aims to promote balance among body systems. This reduces the symptoms of neurological disorders associated with sympathovagal imbalance. Furthermore, this effect is achieved without the need for surgery or the side effects of medications. Approved as a Class IIa medical device under the European Medical Device Regulation (EU-MDR), tVNS® sets a new standard by combining efficacy, safety and ease of use in the treatment of neurological diseases. tVNS® is indicated for the treatment of the following clinical conditions: ✓Anxiety ✓Atrial Fibrillation ✓Autism ✓Cognitive Disorders ✓Depression ✓Epilepsy ✓Crohn's Disease ✓Inflammatory Bowel Disease ✓Migraine ✓Parkinson ✓Prader-Willi Syndrome ✓Sleep Disorders ✓Systemic Sclerosis ✓Tinnitus Why Choose tVNS® Device? tVNS®: The Only Non-Invasive Vagus Nerve Stimulation Device with EU-MDR Approval tVNS® is the only non-invasive vagus nerve stimulation device approved as a Class IIa medical device under the European Medical Device Regulation (EU-MDR). This innovative, clinically validated, non-surgical method offers a safer and more comfortable alternative to invasive procedures. Using patented electrode technology, it provides maximum effectiveness by stimulating the concha cymba, targeting the auricular branch of the vagus nerve (100% innervation). Unlike other devices that only provide partial innervation, tVNS® is a unique solution that maximizes effectiveness in this regard. EU-MDR Cla ss IIa EU-MDR Approved Medical Device tVNS® is the only non-invasive vagus nerve stimulation (VNS) device approved under the European Medical Device Regulation (EU-MDR). Our device has a unique stimulation technology that targets the cymba concha region, providing 100% innervation of the auricular branch of the vagus nerve. Unlike other devices on the market, they provide partial innervation by stimulating different anatomical areas and are not manufactured to the same quality and safety standards as tVNS®. Non-Surgical Clinical Approach tVNS® provides the clinical effectiveness of vagus nerve stimulation without the risks and operational difficulties associated with surgical interventions. In this way, patients can benefit from significant therapeutic benefits in a non-invasive way and under their own application control. Minimal Side Effects The process of moving away from pharmacological treatments often goes hand in hand with the search for fewer side effects. tVNS®, a drug-free method, offers a safer treatment alternative by reducing the risk of long-term adverse effects. German Engineering and Production Quality Our commitment to excellence ensures that every tVNS® device meets the highest standards for quality and performance. Our devices are developed with durability and innovative design in mind, reflecting Germany's long-established engineering and manufacturing precision. With tVNS®, you invest in a technology focused on clinical success, trusted by healthcare professionals and researchers worldwide. Mobile App-Supported Therapy Experience Tracking and understanding your treatment progress is critical to clinical success. The tVNS® Patient mobile application developed for this purpose not only provides real-time monitoring but also enables seamless sharing of data with healthcare professionals. Access from Anywhere In today's world, remote access is of great importance for patient comfort. In response to this need, tVNS® offers a combination of device delivery directly to the patient's address and distance learning support. In this way, patients can easily begin their treatment process without the necessity of travel or logistical restrictions. Pediatric Compatibility tVNS® has been rigorously designed and approved for use in children. In this way, it fills an important gap in pediatric treatment in a safe and effective manner. Easy to Use Functionality should not compromise on simplicity. Standing out with its advanced technology, the tVNS® device is also as user-friendly as a smartphone and can be effortlessly integrated into your daily routine. tVNS® treatment stands out for its ease of use and integration into daily life . At the heart of this method is the principle of neurostimulation, which utilizes the vagus nerve's ability to influence various bodily functions and systems. tVNS® stimulates the auricular branch of the vagus nerve (ABVN) with gentle electrical impulses delivered through the skin. These impulses generate therapeutic signals that are transmitted first to the brainstem and then to higher centers, aiming to alleviate disorders within the nervous system. The device is designed with a completely patient-centered approach: easy to use, portable, and discreet. This allows you to integrate treatment sessions into your schedule without disrupting your daily routine. Whether you're at home, at work, or traveling, tVNS® offers a consistent and accessible solution for managing the symptoms of neurological disorders, including reducing seizure frequency in epilepsy. Each session with the tVNS® device is a step toward rebalancing the nervous system. This method uses the body's natural pathways to support healing and symptom relief. The device's ease of use makes starting and maintaining treatment extremely convenient. This empowers users to take control of their health through a non-invasive and effective method. Mechanism of Action of tVNS® Therapy tVNS® is designed to be portable and easy for patients to use at any time of the day and in any environment they choose. tVNS® Clinical Research and Patient Tracking Application Two Apps Integrated with Your tVNS® R Device: tVNS® Research and tVNS® Patient Your tVNS® R device provides access to two applications developed for research and patient monitoring: tVNS® Research and tVNS® Patient. The tVNS® Research app allows all technical parameters to be easily reprogrammed and transmitted wirelessly to the device. This gives researchers the flexibility to experiment with entirely new stimulation protocols. Technical and patient data can also be collected and securely stored through the app. The tVNS® Patient app automatically records all stimulation data (application time, duration, parameters, etc.). Additionally, it offers a structured survey module where patients can provide feedback on their experience. The tVNS® Patient app is fully compliant with the General Data Protection Regulation (GDPR). This means patient data is processed and stored in accordance with the highest confidentiality and security standards. tVNS® Technology Supported by Clinical Research Multi-center clinical studies and scientific research demonstrate the proven efficacy and safety of tVNS®. Thanks to our unique stimulation approach focused on the cymba concha region, our high quality standards, and our strong clinical data base, tVNS® has become a preferred neurotherapeutic solution for researchers. This holistic approach positions tVNS® at the forefront of innovation and patient-centered care in the field of neuromodulation. Epilepsy After 20 weeks of treatment, patients receiving active tVNS® had an average 34.2% reduction in seizure frequency. Prader-Willi-Syndrome After 12 months of treatment, 80% of patients treated with tVNS® had an average 50% reduction in the number of daily seizures/attacks compared to pre-treatment levels. Depression tVNS® administration, when used in conjunction with psychopharmacological treatment and psychotherapy, resulted in a reduction of at least 2–3 points in depression-specific HAMD scores in adult patients after a 9-week period. Migraine tVNS® treatment resulted in a 50% reduction in the frequency of migraine days after 12 weeks of treatment. Click for more information and clinical studies about the tVNS® Research device. tVNS® Research devices Clinical Research Enter a New Era in Patient Treatment with tVNS® Discover how tVNS® can transform your treatment approach. Incorporate this innovative solution into your practice, offering a safe and non-invasive way to heal your patients who haven't seen satisfactory results with conventional treatment methods. Let's take a step together to pioneer an innovative and people-centered approach to healthcare. Contact our expert experts to learn more about how you can integrate tVNS® into your clinical practice and the benefits it can provide for your patients. Together, let's pave the way for a healthier future and a higher quality of life. Contact us

tVNS® CARE Therapy Tracking tVNS® CARE Therapy Tracking In medical device treatments that can be applied at home without a doctor's supervision, the most important requirement for the success of the treatment is that a protocol specific to the patient's needs is prepared and that the patient is using the device correctly and is monitored by the doctor and a team of experts. The world-unique tVNS Care® Technology is a digital health service that can increase the success rate of treatment by up to 50%*, where a patient-specific program is prepared by referencing the protocols of similar patients in more than 50 countries, and all details of the treatment can be monitored online by our expert teams. tVNS Therapy Devices tVNS Health website tVNS® vagus therapy devices offer a non-surgical neuromodulation treatment option by providing auricular vagus nerve stimulation in difficult-to-treat brain diseases with the help of a smartphone-sized device and a special electrode. With its innovative mobile application, the patient can share all the treatment information with a single click without leaving his home, and reach the necessary follow-up and support. tVNS® stimulates the branch of the vagus nerve in the auricle through the skin with gentle electrical impulses. Signals are passed on to the brain via special nerve fibers: first in the brain stem and then in higher centers. The treatment with tVNS® is applied by patients independently. It has been used by thousands of patients and is a treatment with very few side effects.