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Changing the World, Changing the Lives In More than 50 Countries of the World With Our 20 Years of Vagus Treatment Experience We Are Here for a Brand New Quality of Life Our tVNS® health solutions help thousands of patients to discover a brand new quality of life. What is tVNS®? tVNS® is a medical device for the treatment of symptoms of sympathovagal imbalance and was specially developed for patients who are not free of symptoms despite drug therapy. tVNS® stimulates the branch of the vagus nerve in the auricle through the skin with gentle electrical impulses. Signals are passed on to the brain via special nerve fibers: first in the brain stem and then in higher centers. The treatment with tVNS® is applied by patients independently. It has been used by thousands of patients and is a treatment with very few side effects. tVNS® is indicated to treat sympathovagal imbalance in the following conditions: Anxiety Migrain Autism Cognitive Impairment Depression Fibromyalgia E p ilepsy Inflammation Pr ader-Willi Syndrome Sleep Disorders Stroke Tinnitus Asthma Crohn's Disease Atrial Fibrillation Parkinson's tVNS® CARE Therapy Tracking THE MOST EFFECTIVE WAY TO GET RESULTS FROM tVNS®* For patient-driven medical device treatments that the patient can apply at home without the supervision of a doctor, the most important need for the success of the treatment is the preparation of a protocol specific to the patient's needs and the remote follow-up by the doctor and an expert team to see whether the patient can use the device correctly. tVNS Care®, o ur unique digital health service, where a patient-specific program is prepared based on the protocols of similar patients in more than 50 countries and all details of the treatment can be followed online by our expert teams. Why Treatment with tVNS® Device? Customized Therapy t VNS® therapies are customized for each patient, based on indication and needs, so can provide a unique solution for every patient. More Flexibility With the help of the rechargeable battery, it allows several different parameters and treatment protocols. Innovative App With the tVNS® Patient App you can track your treatment, share results with your doctor and get therapy consultation wherever you are R emote Training tVNS® allows remote delivery and training without any need for travel, so that any patient can start using the therapy on their home No Surg ery tVNS® enables non-surgical vagus nerve stimulation with full patient control and no invasive- risks Few Side Effects tVNS® has very few side effects compared to drugs and invasive treatments, and easily tolarable. Pediatric Flexibility It can be used safely at any age from newborn babies with the approval of the doctor. Easy to Use tVNS® is easy to use, as small as a smartphone and can be easily integrated into everyday life. Treatment Stories of tVNS® Patients Our doctor Barış Ekici has contributed a lot to my autistic son Kaan. We have benefited greatly from the tVNS treatment, which is Vagus nerve stimulation. We have seen progress in his word count and awareness. He has become calmer, his hyperactivity has decreased, and his sleep has become more regular. Dr. Nurbanu Gürbüzer, Istanbul, Assoc. Prof. Dr. Barış Ekici, mother of a patient followed up Download the tVNS ® Patient App Meet the Tele-Medicine Technologies of the Future With the innovative tVNS® patient app, you can track your treatment at any time and share your data with your doctor. In addition, the tVNS® patient app enables us to continuously improve our technology and optimize your treatment. The tVNS® Patient App is available now in the Google Play Store and in the Apple App Store (EU-only). How does tVNS® work? You can use tVNS® anytime, anywhere. It is easy to use, portable and discrete. tVNS® activates special nerve fibers through gentle electrical impulses (neurostimulation) via an ear electrode on the ear, stimulating the branch of the vagus nerve in the auricle through the skin, by sending nerve signals to the brainstem and the higher centers. This alleviates symptoms of sympathovagal imbalance, for example reducing seizures in epilepsy. Watch this short video to learn more about our tVNS® health solutions and how tVNS® works. Contact us blog Pediatric neurology specialist Associate Professor Dr. Barış Ekici shares his insights and experiences with transcutaneous vagus nerve stimulation therapy tVNS Parkinson Testimonial International Autonomic Neuroscience Society Journal: "tVNS Special Issue" tVNS vagus therapy has started in our first pediatric resistant epilepsy patient in Turkey Contact us Name Surname Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Your E-mail Address Phone Number Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible.

About us The medical technology company Cerbomed GmbH, which was founded in 2003 in Erlangen, led the world in the field of transcutaneous vagus nerve stimulation until 2018. In October 2018, the brand was restructures as tVNS Technologies Gmbh. The new generation device, tVNS®, approved in 2021, is the only non-invasive vagus stimulation device in the world approved for epilepsy, depression, autism, insomnia and many other neurodegenerative diseases. tVNS® has been used in thousands of treatments since 2010 and has significantly improved patients' quality of life. tVNS® devices has been developed and manufactured in Germany. tVNS Health GmbH, based in Munich, Germany is responsible for the worldwide sales and therapy support services for tVNS® devices, serving in more than 40 countries worldwide. Nervovita Medikal Teknolojiler is a medical technology company established by tVNS Health GmbH to carry out its activities in Turkey, Azerbaijan and Balkans, and provides tVNS therapy devices to hundreds of patients. Meet our team Our Vision The patient is at the center of all our activities - customer proximity and customer satisfaction are extremely important to us. Our vision is to increase the quality of life of patients and their loved ones with our solutions, to give them a new life for the future, and to provide a more predictable life. We support our patients in their pursuit of safety, stability, and self-control. İletişim Bilgileri Contact us tvNS Health GmbH Türkiye - Azerbaijan - Northern Cyprus - North Macedonia Office NERVOVITA Medical Technologies RELUX Plaza, FSM Mah Poligon Cad Siir Sok Floor :9 No:58 34771, Umraniye /Istanbul /TURKEY Whatsapp Link +90 850 241 93 15 info@t-vnstherapy.com Our Socia Media Channels tVNS Health GmbH Headquater Südliche Münchner Str. 62, 82031 Grünwald, Germany info@tvns.health www.t-vns.com Whatsapp Link +49 89 24410244 info@tvns.health Our Socia Media Channels Contact us Name Surname Your E-mail Address Phone Number Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible.

AUTISM Groundbreaking Technologies For life What is Autism? Autism is a congenital, neurological disease, and it is a behavioral and verbal disorder that negatively affects a person's quality of life. There are symptoms such as inability to make eye contact, repetitive behaviors, and difficulty in social activities. In addition, individuals with autism are sensitive to sensory stimuli such as lights and sounds. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Autism Asperger's Syndrome: Asperger's Syndrome is the mildest type of autism. The person with this syndrome may be very intelligent and excel at work. However, they have difficulty in socializing. Classical Au tis m: Classical autism, also known as autism, shows symptoms such as communication disorder, restrictive and repetitive behaviors with severe socialization and communication problems. Atypical Autis m: Children who have autism symptoms but do not meet the criteria enough to diagnose the disease are called atypical autism. Speech and communication disorders of individuals with atypical autism can be corrected with early diagnosis and correct treatment methods. Treatment Options for Autism Special Education Treatment It is the surgical intervention of areas in the brain that cause epileptic seizures and do not perform their normal functions. More information Invasive Vagus Nerve Stimulation (iVNS) With a surgical intervention, a battery is placed under the chest and an electrode wire is placed on the vagus nerve in the neck. With the help of the electrode, the vagus nerve next to the carotid artery is stimulated at regular intervals. More information Special Diets They are designed to correct the chemical imbalance in brain cells that causes seizures. These drugs work in different ways, although some are not yet fully understood. More information Transcutaneous Vagus Nerve Stimulation (tVNS) It is a treatment option that stimulates the vagus nerve with the help of an electrode attached to the ear and stimulates the centers in the brain. More information Rett Syndrome: It is a disease as a type of autism that occurs in infancy. The incidence in girls is higher than in boys. It has symptoms such as problems with crawling or walking, decreased eye contact. WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

PATIENT DECLARATION FORM CLINICAL DIAGNOSIS & HEALTH CONDITIONS

insomnia Symptoms, Causes and Diagnostic Methods Insomnia Symptoms Difficulty falling asleep, waking up before expected, Not feeling fresh after sleep, Being angry and aggressive, Feeling tired and sluggish during the day, Difficulty with coordination and focus, Having difficulty remembering events, Being sleepy during the day, Worrying about sleep, Increase in the number of errors and accidents, Hyperactivity, Mood disorders, Anxiety and depression. Causes of Insomnia Stress Environmental disturbances (noise, light, or extreme heat/cold) Disruption of normal sleep patterns (Travel or a newborn baby) Jetlag after travel Medication use for various ailments The cause of the emergence of chronic insomnia. Unlike acute insomnia chronic diseases can also cause mental tension. Asthma chronic body aches heart palpitations chronic stress Depression drug use emotional or physical discomfort Thyroid diseases psychological reasons Insomnia Diagnostic Methods He or she may perform a physical exam to look for signs of medical problems that may be related to insomnia. While investigating the underlying physical diseases that may cause insomnia, it is also investigated whether there is a problem with the thyroid. If deemed necessary, reports of high-resolution imaging methods such as MRI may be requested. For a definitive diagnosis of insomnia, the doctor may request a chart of one or two weeks of sleep patterns or an overnight follow-up at the patient's sleep clinic. Thus, how long you stay awake at night, breathing movements, brain waves and body activities can be monitored and recorded. People with Insomnia Researchers state that 30% to 40% of adults try to cope with insomnia every year. According to the National Sleep Epidemiology Survey (TAPES) in Adults in Turkey, the incidence of insomnia is 15% (Male: 10.5%, Female: 20.2%). Contact us

Tinnitus Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Contact Us

Epilepsy Symptoms, Causes and Diagnostic Methods Epilepsy Symptoms Since epilepsy is a dysfunction that occurs in the brain, the symptoms of epilepsy may vary depending on the function of the affected area of the brain. We can list some symptoms of the disease as follows: Sudden contractions in the body Loss of consciousness Very rapid nodding Uncontrollable shaking in arms and legs wink quickly Looking at a fixed point Being unable to react to sounds or speech for a short time Fear, anxiety or deja vu etc. psychological symptoms Epilepsy Causes Epilepsy is a condition that can have many causes and can occur at any age. It usually starts in childhood. Any disease that affects the brain can cause epileptic seizures. Infections in the womb Birth traumas, lack of oxygen during birth Head injury Genetic and metabolic diseases High fever diseases, Excessive low blood sugar, Intracranial tumors, Brain inflammations. Paralysis Brain tumor Developmental brain malformations Brain infections such as meningitis can lead to epilepsy, Vascular abnormalities, especially in the brain vessels of individuals in the advanced age group, Some epilepsies occur as a result of an electrical activity spreading from this region as a result of disruption in a certain region of the brain. Epilepsies resulting from brain tumors and traumas can be given as examples for this situation. In some types of epilepsy, there is no damage in a single area. An epileptic seizure begins suddenly in the entire brain. Childhood-onset epilepsies are usually of this type. Types of epilepsy also differ from person to person, and this situation also affects the causes and causes of epilepsy. Because not every epilepsy person shows the same symptoms. Epilepsy Diagnostic Methods Imaging methods are one of the primary methods used in the diagnosis of epilepsy. (EEG), (MR) and computed tomography are among the most commonly used imaging methods. EEG, which indicates the electrical activity of the brain, is especially important in the diagnosis of epilepsy. Thanks to EEG, regions of the brain with uncontrolled bioelectrical activity are detected. Whether there is any structural problem that causes seizures is understood by MRI and tomography. If required by specialist physicians, blood and urine tests are also performed. For the diagnosis of epilepsy, the patient's medical history, frequency and severity of seizures, and symptoms are among the points that physicians pay attention to. Sometimes, extreme stress, fatigue, emotional and hormonal changes can also cause seizures. In this sense, not every seizure indicates epilepsy. Physicians can diagnose after listening to patients' stories. People with epilepsy About 50 million people in the world have epilepsy, making epilepsy one of the most common neurological diseases worldwide. It can be seen at any age, although it is more common in childhood and over 65 years of age. Epilepsy can occur in both sexes at any age and in any geographic area. Most people are likely to have an epileptic seizure once in their lifetime. People with more than one epileptic seizure are considered epileptic and should be treated with appropriate medications. In Turkey, 7 out of every 1000 people suffer from epilepsy. Contact us

Use of tVNS® in Children tvNS is safe for children and CE approved for pediatric use It can be used from newborns with the approval of the doctor. Young children should use under parental supervision. Excessive drug use in children can cause developmental delay. tVNS provides long-term positive results by reducing the need for drug use. Reducing drug use helps prevent the side effects of anti-epileptic drugs Improves energy, concentration and mood Mental Development can benefit motor development issues

FAQs Frequently Asked Questions Am I suitable for treatment with tVNS®? 1 tVNS® is a non-invasive device used in the treatment of sympathetic vagal imbalances. It can be used in patients of all ages from 3 years of age. It can be used at any age from newborns with the approval of the doctor. In general, whether you are suitable for treatment is a decision that you will make in consultation with your doctor. If your doctor does not recommend or does not know the treatment, you can contact us. We can contact your doctor . What does it mean for the tvNS® device to be medically approved? 2 The manufacturer of the tVNS® therapy device, Germany-based tVNS Tehnologies GmbH, was established in Germany in 2003 and, as the world's pioneer of this technology, manages the worldwide clinical research and operations of the devices that have received the first medical approval in the world since 2010. With the medical approvals received in 2021 and 2023, it is the only auricular stimulation device that can safely apply vagus nerve treatment and is produced with the latest engineering technologies with the R&D and production team in Erlangen, Germany. Stimulation of the vagus nerve with devices that do not have safety and medical approval can lead to very serious consequences ranging from respiratory to cardiac arrest. Do I need to consult my doctor or device manufacturer for device settings when starting to use tVNS®? 3 No. tVNS® is very easy to use. It can be easily adjusted without the support of a doctor with the device training and instructions for use. When you receive the device, approximately 2 hours of device usage training is given. Afterwards, all settings related to the device are made by Turkey with a remote Bluetooth-supported application. Your therapy protocol is shared with your doctor on a regular basis. How often do I need to use tVNS®? 4 Therapy with tVNS® requires a total of 2 to 4 hours of sessions per day, depending on the indication used. The duration of these sessions can be planned as 1.5 hours. The time at which it will be is determined according to both the indication used and the daily routines and needs of the patient. What side effects might I experience? 5 Therapy with tVNS® is a treatment with very few side effects. In general, two types of side effects are observed. The first of these is local side effects that may occur in the form of itching, redness and pressure sores in the area where the outer auricle is stimulated. On the other hand, since the stimulation of the vagus nerve can affect the autonomic nervous system, systemic side effects may occur. These may include headache, nausea, or dizziness. As with other drug or neurostimulation treatments, an increase in seizures may occur. However, it differs from other treatments in that the side effects usually disappear soon after the end of treatment. Can I avoid taking medication if I choose tvNS ® treatment? 6 tVNS® therapy is an adjunct to medication, if you decide to stop or reduce your medication you should discuss this with your doctor. In general, it is not recommended to start a new drug, increase or decrease the dose, or start it simultaneously with another treatment at the time of initiation of treatment. In this way, we can observe the effects of tVNS® more objectively. How long will I need to use tVNS® treatment and how long will it take for the treatment to work? 7 tVNS® treatment is not an acute treatment, there is no external drug intake. It provides a long-term treatment option by stimulating certain centers of the brain and increasing the release of neurotransmitters over time, eliminating the sympathovagal imbalance. Like most drugs and neuromodulatory therapies for epilepsy treatment, tVNS® therapy is a long-term therapy. Even if you do respond to treatment with tVNS®, the effect usually starts with a delay of just a few weeks to months. Can tVNS ® be used by children? 8 tVNS® can be safely used by children under parental supervision. It was applied to two different 8 and 9 months old babies with the approval of a doctor in Turkey and no negative results were encountered. If it will be used with children, the sessions must be given under parental supervision. tVNS® can be used by children 6 years and older. If it is to be used in children younger than 6 years old, the sessions must be performed under the supervision of the parents. How can I access tvNS ® ? 9 If deemed appropriate by your doctor for the treatment of tVNS®, you can apply to our center and obtain the device. After planning how to use the device and the treatment protocol, you can start the treatment by receiving remote treatment support. 1 0 What are the approved indications of the device? Indicated since 2021 for Anxiety, Migraine, Autism, Cognitive Impairment, Depression, Fibromyalgia, Epilepsy, Inflammation, Prader-Willi Syndrome, Sleep Disorders, Stroke, Tinnitus, Asthma, Crohn's Disease, Atrial Fibrillation and Parkinson's. Apart from this, researches continue on different subjects such as neural plasticity, coma and diabetes. What is the usage rate of tVNS® in the world? 11 tVNS® is the only medically approved sympatovagal ear stimulation treatment in the world, and is used in more than 40 countries in the world's most specialized universities, hospitals and clinics. We mobilize all this communication network to create treatment protocols for patients with special conditions, and we become the architects of medical studies that determine the future of neuromodulation treatments. What are the indications (effects) of the t-VNS ® device? 12 1) It undertakes the task of increasing the activity of the parasympathetic nervous system (resting mode). 2) It provides the balance of neurotransmitter hormone that the body cannot produce enough. 3) It helps to increase brain plasticity (Neural plasticity /: the ability of the brain to undergo structural or physiological changes) in the medium and long term. 4) Reducing inflammation. In recent years, clinical studies of tVNS® have proven the inflammatory effects of nerve stimulation. Inflammation (colloquially known as inflammation/inflammation) in the simplest terms, against all kinds of foreign factors or internal-external tissue damage of living tissue; cellular (cellular), body fluid (humoral) or veins (vascular) are some series of reactions on the basis. By developing inflammation, the body actually aims to destroy the disease factor, to isolate the factors that it cannot destroy from healthy tissues or to eliminate damaged tissues. It is divided into acute and chronic inflammation. Examples of acute inflammation: Redness, swelling, fever, pain, edema, increased temperature Examples of chronic inflammation: Cancer, ALS, heart diseases, diabetes, hypertension, asthma, depression, neurological diseases Is the response time of vagal stimulation therapy (vagus nerve stimulation) the same in patients of all ages? 13 It has been observed that the earlier the patient starts vagal nerve stimulation therapy or the shorter the epilepsy history, the shorter the response time to the disease. For example, a 40-year-old epilepsy patient may take longer to respond to vagal nerve stimulation treatment than a pediatric epilepsy patient. Is nonsurgical tVNS (through the skin) vagus nerve stimulation) only a preliminary step for patients responding to surgical VNS therapy? Should epilepsy patients who respond to cutaneous vagus stimulation therapy switch to invasive therapy? 14 tVNS® therapy may be a preliminary step for invasive vagal nerve stimulation requiring surgical intervention, but it is also an alternative treatment modality. The reasons for this are; I. Not every patient is suitable for invasive intervention. II. In case of failure to respond to treatment, removal of the electrode is difficult and risky, as the tissues of the vagus nerve wrap and fuse with the electrode. Even if the battery is removed, the patient will have to live with an inactive implant electrode in his body for life. It may cause pain or pressure, and infection may develop over time. Can the transcutaneous (through the skin conduction/non-invasive) method and the Invasive (surgical implant) method give the same effect in vagal nerve stimulation? 15 According to fMRI studies, it has been proven that both methods stimulate the same points in the brain. However, tVNS® has some advantages over the invasive method: 1. Contrary to the invasive alternative, since it has a rechargeable battery, it can give electrical stimulation as more frequent and intense programs. 2. As with the invasive alternative, high currents up to 5MA can be given, as it does not directly give the electric current attached to the nerve and does not pose the risk of nerve damage. Why does not every patient respond to his treatment in the same way or at the same rate? 16 There are different hypotheses about this, one of them is myelin thickness. Thick myelin nerves conduct electrical conduction better, and in this way vagus nerve stimulation can be done more effectively. Myelin thickness can vary from person to person genetically. Studies have shown that patients with thick myelin nerves respond better to treatment. What is the direct current (milliamps) to stimulate the ear? 17 There are scientifically proven studies on this subject. The minimum electrical current required to stimulate the vagus nerve is kept somewhat below the pain/pain threshold so that it does not activate the pain nerves. For this reason, there should be no pain or pain during stimulation, but a distinct vibration sensation. This is the most optimal stimulation intensity and should be at a level that does not disturb the patient. In which situations can the device not be used during the day? 18 You can safely use the tVNS® device while mobile, while walking, watching TV, reading a book, or at the computer. For safety reasons, it is recommended not to be used while driving to avoid distractions. It is recommended that the device be turned off when passing near high magnetic fields and devices that create high magnetic fields. Apart from this, it can be used in children both while they are asleep and awake. Adults are advised not to sleep while performing self-therapy. In order to avoid the risk of any cable entanglement around the neck, our children can be given therapy both while awake and asleep under parental supervision. To what extent does tVNS ® treatment affect epileptic seizures? 19 According to clinical studies conducted in 2000 patients using the tVNS® device between 2010 and 2018, a significant reduction in the severity and number of seizures was observed in an average of 60% of the patients. It can be said that a secondary effect, which is widely seen, is an increase in vitality, cognitive progress and improvement in sleep patterns. It can completely stop seizures in 10-20% of patients.

PATIENT DECLARATION FORM CLINICAL DIAGNOSIS & HEALTH CONDITIONS

Cognitive Impairment Symptoms, Causes and Diagnostic Methods Cognitive Disorder Symptoms Forgetfulness Lack of attention Excitement Unrest Speech difficulties Sleep disorder Causes of Cognitive Impairment Although the exact cause of cognitive impairment is not known exactly, the person's predisposition to Alzheimer's and dementia causes this disease. The following situations may also be the cause of cognitive impairment; Thyroid, kidney, or liver problems Depression, anxiety and stress Conditions that affect blood flow in the brain Vitamin B12 deficiency Cognitive Disorder Diagnostic Methods The diagnosis of cognitive disorder is made by neurology and psychiatry specialists. At this stage, it is very important to be accompanied by someone who knows and observes the patient closely. People with Cognitive Disorder The incidence in people over the age of 65 is around 15-20%. People with cognitive impairment are likely to progress to Alzheimer and dementia. However, cognitive impairment may not always be progressive. Contact us

What is Vagus Nerve? The vagus nerve is the longest cranial nerve in the body. It comes from the Latin word, vagus, for “wandering.” That’s because it wanders throughout your body, with wide distribution connecting the brainstem to the body. Only mammals have this nerve. The vagus nerve serves as the body's superhighway, carrying information between the brain and the internal organs and controlling the body's response in times of rest and relaxation. It helps the immune system and inflammation response to disease. It has four main functions: sensory, special sensory, motor and parasympathetic. The vagus nerve also manages fears and sends information from the gut to the brain, which is linked to dealing with stress, anxiety, and fear–hence the saying, ‘gut feeling'. Discover Historical Development of Vagus Nerve Stimulation Epilepsy has existed in human history with the first record found in a Babylonian text written 4000 years ago, and humanity has sought a cure for this disease for centuries. With the emergence of neurology in the 19th century, the mechanism between the nervous system and epilepsy was tried to be solved and the first vagus nerve stimulation was tried by a New York neurologist in the early 1880s. Over the next 100 years, the effects of vagus nerve stimulation were first investigated in animal experiments, then in humans, and in 1996, the vagus nerve was surgically implanted into the body and become an invasive stimulation option. At the beginning of the 2000s, for eliminating the side effects of invasive VNS, scientists tried to find out ways to stimulate the vagus nerve non-invasively, and by 2010 these studies were concluded successfully. Our first generation device, Nemos, was approved in 2010 for the treatment of epilepsy and depression, and Vitos in 2012 for the treatment of pain and migraine, as the first medically approved non-invasive vagus nerve stimulation treatment in the world. Our 2nd generation device, tVNS-L, has been approved in 2021, and has become a treatment option used in many neurodegenerative diseases. Vagus Nerve Stimulation Effect Overview Regulation of neurotransmitter release Increase in parasympathetic activity Increase in brain neuroplasticity Reducing inflammation Increasing the secretion of serotonin and increasing the mood What Are the Effects of Vagus Nerve Stimulation? Stimulation of the vagus triggers regulatory mechanisms in the nervous, immune, autonomic, endocrine, cardiorespiratory, and gastrointestinal systems. Clinical studies on the vagus nerve have shown that the activity in this nerve is closely related to epilepsy, depression, migraine, headache, inflammatory bowel disease, Alzheimer's, arthritis and many other common disorders by activating the parasympathetic nervous system in the brain and increasing the secretion of neurotransmitters in special regions of the brain. shows. Vagus nerve stimulation therapies are approved by FDA in the USA and CE in Europe for use in treatments such as mood improvement, pain relief, sleep improvement, memory enhancement and anxiety reduction. Research continues on the effects of neuroplasticity as well as its cardiac and inflammatory properties.