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tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Migraine Symptoms, Causes and Diagnostic Methods Migraine Symptoms Migraine symptoms usually begin in the teenage years. The probability of its occurrence increases from the last stages of adolescence, and this probability decreases after the age of 35. As it is known in people with migraine, the most common and most severe symptom is headache. This headache can sometimes be so severe that it puts the person in bed. The most common areas of migraine attacks are the back of the head, behind the ears and forehead. Other physical symptoms of migraine are the desire to drink excessively, increase in appetite, diarrhea or constipation depending on the situation, and swelling in the abdomen. In addition to these physical symptoms, people who experience migraine attacks also experience various emotional symptoms. Symptoms such as depressed mood, excessive cheerfulness, excessive stagnation, concentration disorders, olfactory sensitivity, attention deficits, hypersensitivity and an intense desire for sleep can be seen. Migraine Causes Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. Triggers of Migraine Hormonal changes experienced by women Hormone medications, such as oral contraceptives (birth control pills) and hormone replacement therapy Some foodstuffs Stress plays an important role in migraine attacks. Stress at work or home life may be the cause of frequent migraine attacks. Loud noises, bright lights, or exposure to sunlight Changes in sleep and wake patterns Migraine attacks may occur with sexual activity or intense physical exertion. Ambient air pressure or barometric changes can trigger migraines. Medicines; Vasodilators (vasodilators) such as nitroglycerin or oral contraceptives (birth control pills) can worsen migraines. Brain tumor Migraine Diagnostic Methods Diagnosis is made during the interview by a specialist physician. If you are experiencing any of the following symptoms, you should see a doctor immediately; Sudden, severe headache like thunder Fever, stiff neck, confusion, double vision, drowsiness, or slurred speech Worsening of headache, especially after a head injury A headache that develops after coughing, exertion, straining, or a sudden movement New onset headache over 50, Migraine is not known enough and its treatment is not done because patients do not apply to the neurology department and try to control their headaches with painkillers. If you regularly experience migraine attacks and symptoms, it is useful to record them. If you think that the attacks and severity of your headaches have changed, you should definitely see a neurologist as soon as possible. For the diagnosis of epilepsy, the patient's medical history, frequency and severity of seizures, and symptoms are among the points that physicians pay attention to. Sometimes, extreme stress, fatigue, emotional and hormonal changes can also cause seizures. In this sense, not every seizure indicates epilepsy. Physicians can diagnose after listening to patients' stories. Genetic factors take the first place among the causes of migraine headaches. The incidence of migraine in patients with a family history of migraine varies between 40% and 75%. Hormonal changes also cause an increase in migraine attacks. Migraine attacks are 3 times more common in women than in men. Migraine Who has visible Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır INSOMNIA (SLEEP DISORDER) Groundbreaking Technologies for Life What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Treatment Options for Insomnia What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Treatment Options for Insomnia Uykuya Dalma ve Sürdürme Sürelerinde İyileşme Parasempatik Aktivitenin Artışı Uyku Kalitesinde Objektif Artış What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Sleep Tests Air flow in and out of the lungs during breathing Blood oxygen levels. Body position. More information CPAP Titration (Mask Therapy) In some cases of severe depression, hospitalization is necessary. This may be necessary if the individual is unable to care for themselves properly or is in danger of harming themselves or others. More information Polysomnography In other words, a sleep test is a procedure that uses devices to record sleep throughout the night to determine the quality of sleep and identify the cause of sleep disturbances. More information Transcutaneous Vagus Nerve Stimulation (tVNS) The vagus nerve facilitates communication between the gut and the brain. When you're unhappy, the vagus nerve senses that something is wrong and activates the sympathetic nervous system, a key component of the digestive system, which then releases cortisol. More information What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Types of Insomnia Acute insomnia : It refers to the short-term appearance of insomnia. Acute insomnia usually occurs after a stressful day or on days when mental tension is high. Our body clock has a har d time showing when it's time to rest on such difficult days. This irregularity, which usually lasts for 1 to 2 days, continues until we feel better. There are signs of acute insomnia that can last up to 4 weeks. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. Contact us Contact us

tVNS Transkutanöz Vagus Sinir Stimülasyonu cihazıdır. Dirençli Epilepsi, Migren ve Depresyon Tedavisinde Ameliyatsız İlaçsız Kulaktan Vagus Sinirini Uyaran Dünyanın CE onaylı Tek Nöroterapi - vagus stimulasyonu- cihazıdır. tVNS Türkiye , "t-vnstherapy "tek yetkili satıcısıdır. Changing the World, Changing the Lives In More than 50 Countries of the World With Our 20 Years of Vagus Treatment Experience We Are Here for a Brand New Quality of Life Our tVNS® health solutions help thousands of patients to discover a brand new quality of life. What is tVNS®? tVNS® is a medical device for the treatment of symptoms of sympathovagal imbalance and was specially developed for patients who are not free of symptoms despite drug therapy. tVNS® stimulates the branch of the vagus nerve in the auricle through the skin with gentle electrical impulses. Signals are passed on to the brain via special nerve fibers: first in the brain stem and then in higher centers. The treatment with tVNS® is applied by patients independently. It has been used by thousands of patients and is a treatment with very few side effects. tVNS® is indicated to treat sympathovagal imbalance in the following conditions: Anxiety Migrain Autism Cognitive Impairment Depression Fibromyalgia E p ilepsy Inflammation Pr ader-Willi Syndrome Sleep Disorders Stroke Tinnitus Asthma Crohn's Disease Atrial Fibrillation Parkinson's tVNS® CARE Therapy Tracking THE MOST EFFECTIVE WAY TO GET RESULTS FROM tVNS®* For patient-driven medical device treatments that the patient can apply at home without the supervision of a doctor, the most important need for the success of the treatment is the preparation of a protocol specific to the patient's needs and the remote follow-up by the doctor and an expert team to see whether the patient can use the device correctly. tVNS Care®, o ur unique digital health service, where a patient-specific program is prepared based on the protocols of similar patients in more than 50 countries and all details of the treatment can be followed online by our expert teams. Why Treatment with tVNS® Device? Customized Therapy t VNS® therapies are customized for each patient, based on indication and needs, so can provide a unique solution for every patient. More Flexibility With the help of the rechargeable battery, it allows several different parameters and treatment protocols. Innovative App With the tVNS® Patient App you can track your treatment, share results with your doctor and get therapy consultation wherever you are R emote Training tVNS® allows remote delivery and training without any need for travel, so that any patient can start using the therapy on their home No Surg ery tVNS® enables non-surgical vagus nerve stimulation with full patient control and no invasive- risks Few Side Effects tVNS® has very few side effects compared to drugs and invasive treatments, and easily tolarable. Pediatric Flexibility It can be used safely at any age from newborn babies with the approval of the doctor. Easy to Use tVNS® is easy to use, as small as a smartphone and can be easily integrated into everyday life. Treatment Stories of tVNS® Patients Our doctor Barış Ekici has contributed a lot to my autistic son Kaan. We have benefited greatly from the tVNS treatment, which is Vagus nerve stimulation. We have seen progress in his word count and awareness. He has become calmer, his hyperactivity has decreased, and his sleep has become more regular. Dr. Nurbanu Gürbüzer, Istanbul, Assoc. Prof. Dr. Barış Ekici, mother of a patient followed up Download the tVNS ® Patient App Meet the Tele-Medicine Technologies of the Future With the innovative tVNS® patient app, you can track your treatment at any time and share your data with your doctor. In addition, the tVNS® patient app enables us to continuously improve our technology and optimize your treatment. The tVNS® Patient App is available now in the Google Play Store and in the Apple App Store (EU-only). How does tVNS® work? You can use tVNS® anytime, anywhere. It is easy to use, portable and discrete. tVNS® activates special nerve fibers through gentle electrical impulses (neurostimulation) via an ear electrode on the ear, stimulating the branch of the vagus nerve in the auricle through the skin, by sending nerve signals to the brainstem and the higher centers. This alleviates symptoms of sympathovagal imbalance, for example reducing seizures in epilepsy. Watch this short video to learn more about our tVNS® health solutions and how tVNS® works. blog Contact us Name Surname Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Your E-mail Address Phone Number Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible. Contact us

DEPRESSION Groundbreaking Technologies for Life " The scientific solution for depression: tVNS®. The life of a 17-year-old girl diagnosed with medication-resistant, suicidal depression was completely changed by transcutaneous vagus nerve stimulation. This clinically proven, non-invasive method is especially promising for young individuals. It enables the safe management of depression by affecting the brain's mood centers via the vagus nerve. Key Features of tVNS®: Clinically proven effectiveness, non-invasive and drug-free therapy, the ability to monitor your recovery process, and suitability for pediatric use. " What is Depression? Depression is a mood disorder that causes constant sadness and loss of interest. Depression is also called major depressive disorder or clinical depression. The feelings, thoughts and behaviors of individuals suffering from this condition are affected and various emotional or physical problems may arise due to this. There may be problems doing normal daily activities, and sometimes life may seem not worth living. Depression is not just a feeling of malaise or momentary weakness. Depression is also not such a simple problem that it can be solved in an instant. Depression is a treatable medical condition that requires treatment. This treatment process may take a long time in some cases. Everyone goes through periods of not feeling well emotionally and psychologically from time to time. These periods generally last for a certain period of time, depending on the intensity of the troubles and sorrows you experience. However, if your bad periods last longer than two or three weeks and prevent you from doing many of the things you do in your daily life properly; this condition is called depression (major depressive disorder). SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Depression The symptoms caused by major depression are different for each individual. Medical professionals look for various markers or traits that clarify an individual's type of depression. A marker or feature may indicate the presence of a particular type of depression: Anxiety distress : Unusual restlessness or depression with worry about possible events or loss of control. Atypical features : Depression with temporary happiness from certain events, increased appetite, excessive need for sleep, hypersensitivity to rejection, and a feeling of heaviness in the organs. Mixed features : High self-esteem, and energetic mania concurrent with depression involving too much talk Catatonia : Depression with uncontrollable motor activity and purposeless movements or with fixed and rigid postures. Melancholic features : Depression, which is seen as a cooling reaction to something that once brought pleasure, depression that may be accompanied by worsening mood, weakness or agitation during waking up early in the morning. Seasonal features : Depression triggered by seasonal changes and less exposure to sunlight. Peripartum onset : depression that occurs during pregnancy or in the weeks or months after birth, that is, in the "postpartum" period Psychotic features : depression accompanied by personal inadequacy or other negative delusions or hallucinations Treatment Options for Depression Drug Therapy The medications to be used during depression treatment should be determined under the supervision of a doctor. More information Hospital Treatment In some cases of severe depression, hospitalization is necessary. This may be necessary if the individual is unable to care for themselves properly or is in danger of harming themselves or others. More information Psychotherapy It is a general term used for an individual pursuing treatment for depression by talking with a mental health professional about their condition and related issues. More information Transcutaneous Vagus Nerve Stimulation (tVNS) Increased parasympathetic activity promotes relaxation and well-being. Increased serotonin release also boosts mood. More information WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Crohn's Disease Groundbreaking Technologies for Life Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. What Can tVNS® Do for Crohn's? " The scientific solution against Crohn's disease and Irritable Bowel Syndrome (IBS): tVNS® Transcutaneous vagus nerve stimulation has yielded promising results in many patients diagnosed with Crohn's disease and IBS, which are resistant to medication and severely reduce their quality of life. This clinically proven, non-invasive method contributes to the safe management of gastrointestinal symptoms by regulating the gut-brain axis. It stands out as a new treatment option, particularly for chronic intestinal disorders . Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. May reduce the release of proinflammatory cytokines such as TNF-α, IL-1β and IL-6 Can suppress the inflammatory activity of macrophages It can re-establish the immune balance in the intestinal mucosa In a 2016 study conducted by Bonaz and colleagues, seven individuals with active Crohn's disease received chronic vagus nerve stimulation (VNS) therapy for six months. The primary goal of the study was to achieve clinical remission (reduction of CDAI scores), while secondary goals included immune markers (CRP and/or fecal calprotectin) and endoscopic improvement, as well as restoration of vagus nerve tone (as measured by heart rate variability). Stimulation was well tolerated by all patients, with no significant side effects. Two patients were withdrawn from the study three months into treatment due to clinical worsening. The remaining five patients experienced both clinical remission, biological improvement, and endoscopic improvement, and vagal tone was restored. These results provide initial evidence that VNS may be a feasible, safe, and effective treatment option for active Crohn's disease. What is Crohn's Disease ? Crohn's disease is a type of inflammatory bowel disease that causes inflammation of the gastrointestinal tract from the mouth to the anus. This inflammation can be attached to one or more parts of the digestive system, but it is usually seen in the ileum, which is the last part of the small intestine, and in the beginning of the large intestine. Crohn's disease can cause inflammation in your digestive tract, leading to abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition. Growth-development retardation in children may be signs of Crohn's disease. Extra-intestinal diseases are also observed in a quarter of Crohn's patients. These mostly occur in the skin, joints, eyes, liver and biliary tract, kidney and urinary tract, vascular heart and lungs. Crohn's Disease Symptoms Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Crohn's Disease Diagnostic Methods Blood analysis stool analysis Stomach, small and large intestine films Colonoscopy and endoscopy CT and MRI images Crohn's Disease Diagnostic Methods Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Corticosteroids Immunosuppressants Aminosalicylates Biological agents (anti-TNF α) Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Clinical Response in Human Studies In a study by Bonaz et al. (2016), a significant decrease in disease activity scores (CDAI) was noted in the majority of Crohn's disease patients who underwent tVNS. At 6-month follow-up, clinical remission was achieved in more than 60% of the tVNS group. No side effects were observed in this study, and patients' quality of life also improved. Changes in Immune Profile and Cytokine Responses While pro-inflammatory cytokine levels decreased in patients undergoing tVNS, an increase in anti-inflammatory IL-10 levels was detected. A Drug-Free and Safe Alternative tVNS offers a promising approach, especially for patients who do not respond to immunosuppressive therapy, who are discontinuing medication due to side effects, or who wish to avoid surgery. Crohn's Disease Causes Immune system: It is possible for a virus or bacteria to trigger Crohn's disease; however, scientists have yet to identify such a trigger. When your immune system tries to fight off the invading microorganism, an abnormal immune response can cause the immune system to attack cells in the digestive tract as well. Heredity: Crohn's disease is more common in people with a family history of the same disease, so genes may play a role in the occurrence of the disease. 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General terms and conditions for consumers § 1 General, Scope (1) These general terms and conditions for online sales (“GTC”) apply to the purchase or rental agreement concluded between TVNS Technologies and the buyer for the purchase or rental of a tVNS® therapy device and corresponding spare parts (“products”) via the TVNS Technologies online shop at www.shop.t-vns.com (“online shop”). (2) The buyer’s contractual partner is tVNS Technologies GmbH Ebrardstr. 31 91054 Erlangen E-Mail: support@t-vns.com Register court Fürth – HRB 17082 Managing directors authorized to represent: Prof. Dr. Armin Bolz and Lars-Oliver Bolz – hereinafter referred to as either “we” or “TVNS Technologies”. (3) Individual agreements made on a case-by-case basis between TVNS Technologies and the buyer (including side agreements, additions and changes) always take precedence over these GTC. A written contract or our written confirmation is authoritative for the content of such agreements. (4) Legally relevant declarations and notifications which the buyer has to submit to us after the conclusion of the contract (e.g. setting of deadlines, notifications of defects, declaration of withdrawal or reduction in price) must be made in writing. (5) References to the validity of statutory provisions are only used for clarification purposes. Even without such a clarification, the statutory provisions apply, unless they are directly amended or expressly excluded in these GTC. § 2 conclusion of contract (1) Images of the products in our brochures, on our website or in other offer documents are only approximate, unless we have expressly designated the information there as binding. (2) Before placing the order, the selected product, its total price including taxes and duties, if applicable the type of calculation of the total price, any additional freight, delivery, shipping and other costs as well as any additional services selected will be displayed again in a window displayed for review. The buyer can then recognize any input errors and correct them before submitting his binding order. The contractual provisions including the GTC can be called up again before the contract is concluded and saved in a reproducible form. By clicking the “order for a fee” button, the buyer submits his order and thus a legally binding offer to purchase the selected product, subject to these terms and conditions. (3) When ordering a tVNS® therapy device, the buyer has to send TVNS Technologies, unless otherwise agreed in individual cases, a letter of recommendation from him or, if the buyer is not identical with the user, a recommendation letter from the doctor treating the user or to hand over, from which it follows that the buyer or the user is suitable for therapy with the NEMOS® therapy device. This is an essential prerequisite for the acceptance of the buyer’s contract offer by TVNS Technologies. (4) TVNS Technologies will confirm receipt of the order by email (“order receipt confirmation”). However, this confirmation of receipt of order does not yet represent acceptance of the contract offer by TVNS Technologiess. TVNS Technologies remains entitled to reject the buyer’s offer of contract even after the confirmation of receipt of order has been sent. (5) Unless otherwise stated in the buyer’s order, we are entitled to accept this contract offer within 14 days of our receipt. (6) Our acceptance can be declared either in writing (e.g. by order confirmation) or by delivering the product to the buyer. With acceptance by TVNS Technologies, a binding purchase contract between TVNS Technologies and the buyer is concluded on the basis of these terms and conditions § 3 Delivery Period and Delay in Delivery (1) The delivery times and dates result from the information in the order process. Delivery times are only binding if the buyer has provided us with all necessary information and documents. (2) If we are unable to meet the delivery deadlines and dates that have been announced, we will inform the buyer before we accept the order and ask the buyer whether he wants to maintain his order based on the new delivery deadlines and delivery dates. If the customer confirms this, TVNS Technologies can accept the order in accordance with § 2 (6). If we culpably fail to meet a binding delivery date or are in default for any other reason, the buyer can withdraw from the purchase contract after a reasonable additional grace period has expired without success. In particular, this does not apply if the buyer has given TVNS Technologies an incorrect delivery address. § 4 delivery (1) Der Käufer steht dafür ein, dass er TVNS Technologies die zutreffende Lieferadresse angibt. Soweit nicht etwas anderes vereinbart ist, sind wir berechtigt, die Art der Versendung (insbesondere Transportunternehmen, Versandweg, Verpackung) selbst zu bestimmen. Wenn und soweit die vom Käufer angegebene Lieferadresse unzutreffend ist und TVNS Technologies das Produkt nach Rücksendung an eine neue, vom Käufer angegebene Lieferadresse liefert, ist TVNS Technologies berechtigt, vom Käufer eine Aufwandspauschale in Höhe von 25 EUR zu verlangen. Der Käufer ist zum Nachweis berechtigt, ein solcher Aufwand sei nicht entstanden oder wesentlich niedriger als diese Aufwandspauschale. Nach 3 erfolglosen Versuchen seitens TVNS Technologies, das Produkt an eine jeweils vom Käufer angegebene Lieferadresse zu senden, ist TVNS Technologies berechtigt, von dem Kaufvertrag zurückzutreten. Dies gilt nicht, wenn und soweit die Erfolglosigkeit der Zustellungsversuche auf einem Hindernis aus dem Bereich von TVNS Technologies beruht. (2) The risk of accidental loss and accidental deterioration of the product is transferred to the buyer upon delivery. § 5 prices and terms of payment (1) The total price to be paid by the buyer, including delivery and shipping costs, will be communicated during the ordering process. The prices include the statutory sales tax. (2) The following payment methods are available to the buyer, which he can specify as part of the ordering process: PayPal, advance payment. The payment is debited immediately after the conclusion of the purchase contract, as is the case when ordering accessories. For rental devices, only payment via PayPal is possible. Payment of the total price is due immediately for all orders. In the case of rental equipment, the one-off payment is due immediately; the monthly payments are collected in the following months. Rental devices remain the property of tVNS Technologies GmbH for the entire rental period. After the tenant has terminated the rental agreement in writing, but no earlier than after 12 months, the tenant undertakes to return the device to tVNS Technologies immediately. The tenant undertakesto pay the monthly fee until terminated. (2) With the expiry of the agreed payment deadlines and, if necessary, a corresponding reminder, the buyer is in default. During the delay, the purchase price is subject to interest at the applicable statutory default interest rate of 5% above the respective base rate of the European Central Bank (ECB). We reserve the right to actually claim higher damage. (4) The buyer is only entitled to a right of set-off insofar as his claim has been legally established, is undisputed or has been recognized by us. The buyer may only exercise a right of retention if his counterclaim is based on the same purchase contract. (5) If, after the conclusion of the purchase contract, it becomes apparent that our claim to the purchase price is endangered by the buyer’s inability to perform, we are entitled to refuse performance in accordance with the statutory provisions and – if necessary after setting a deadline – to withdraw from the purchase contract (Section 321 of the German Civil Code). § 6 retention of title (1) The product remains our property until the purchase price has been paid in full. (2) If the buyer acts in breach of contract, in particular if the purchase price is not paid, we are entitled to withdraw from the contract in accordance with the statutory provisions and to reclaim the product on the basis of retention of title and withdrawal. If the buyer does not pay the due purchase price, we may only assert these rights if we have previously unsuccessfully set the buyer a reasonable deadline for payment or if such a deadline is dispensable according to the statutory provisions. § 7 Guarantee and duty of care and cooperation of the buyer (1) The statutory provisions apply to the buyer’s rights in the event of material and legal defects in the product, unless otherwise stipulated in these terms and conditions. (2) The buyer decides alone with his treating doctor whether and in what form the tVNS® therapy device is used for therapy. TVNS Technologies does not make a recommendation in this regard, nor does TVNS Technologies guarantee the success of the therapy. (3) The tVNS® therapy device is only intended for use with patients whose suitability for therapy using transcutaneous vagus nerve stimulation by the NEMOS® therapy device has been determined by a specialist, even if the buyer does not provide TVNS Technologies with a doctor’s letter of recommendation in individual cases. The tVNS® therapy device may only be passed on to the user and not to third parties. If and to the extent that the purchaser passes the tVNS® therapy device on to a user without the aforementioned specialist medical assessment, the purchaser undertakes in any case to only pass on the tVNS® therapy device with its instructions for use and to advise the user to avoid damage to health or other damage explicitly indicate the warnings and instructions for use contained therein.TVNS Technologies assumes no liability for damage to health or other damage that could have been avoided if the information contained in the instructions for use had been observed. This does not apply if and to the extent that TVNS Technologies is legally liable. The buyer also ensures that the tVNS® therapy device is only used in accordance with the medical prescription and in accordance with the information in the instructions for use, if the tVNS® therapy device is used by a third party in need of protection, for example by their parents for children or by people who are otherwise in need of protection, such as the disabled, should be applied.if and to the extent that TVNS Technologies is legally liable. The buyer also ensures that the tVNS® therapy device is only used in accordance with the medical prescription and in accordance with the information in the instructions for use, if the tVNS® therapy device is used by a third party in need of protection, for example by their parents for children or by people who are otherwise in need of protection, such as the disabled, should be applied.if and to the extent that TVNS Technologies is legally liable. The buyer also ensures that the tVNS® therapy device is only used in accordance with the medical prescription and in accordance with the information in the instructions for use if the tVNS® therapy device is used by a third party in need of protection, for example children by their parents or otherwise vulnerable, such as the disabled, should be applied.should be applied.should be applied. (4) TVNS Technologies is neither responsible nor does TVNS Technologies guarantee that the buyer or user is suitable for therapy with the tVNS® therapy device. The buyer / user must clarify this with the doctor treating him and submit the corresponding letter of recommendation to TVNS Technologies in accordance with § 2 (2) of these terms and conditions with the order. Even if the purchaser is medically determined to be fundamentally suitable for therapy with the tVNS® therapy device, TVNS Technologies does not guarantee that the intended therapeutic success will be achieved, nor is TVNS Technologies responsible for this. This also applies if the buyer does not provide TVNS Technologies with a doctor’s letter of recommendation in individual cases. A warranty claim by the buyer can therefore not be based onthat the desired therapeutic success has not occurred. (5) We grant you a two-year guarantee on the tVNS® therapy device. This guarantee is 6 months for the ear electrode. If the device or the electrode no longer works within this time due to material or construction errors, we will remedy this by repairing or sending a new device. In the event of improper handling and interventions by persons not authorized by TVNS Technologies, this guarantee is void. § 8 Limitation of Liability TVNS Technologies’ liability is based on the following provisions: (1) TVNS Technologies is liable for an unlimited amount of damage caused by it or its legal representatives or vicarious agents with intent or gross negligence. (2) In the case of slightly negligent breaches of duty, TVNS Technologies is liable for damage resulting from the breach of essential contractual obligations, limited to the amount of damage typically foreseeable in the contract. TVNS Technologies is not liable for the slightly negligent breach of non-essential contractual obligations. This applies accordingly to the liability of the legal representatives or vicarious agents of TVNS Technologies. (3) The above limitation of liability in accordance with paragraph (2) does not apply in the event of culpable injury to life, limb or health or if TVNS Technologies fraudulently concealed a defect or assumed a guarantee for the quality of the tVNS® therapy device. (4) Mandatory claims of the buyer under the Medical Devices and Product Liability Act remain unaffected. § 9 online dispute resolution Alternative dispute resolution in accordance with Art. 14 Paragraph 1 ODR-VO and § 36 VSBG: The European Commission provides a platform for online dispute resolution (OS), which you can find at http://ec.europa.eu/consumers/odr/ . We are ready to take part in an out-of-court arbitration process. § 10 choice of law For these terms and conditions and all legal relationships between us and the buyer, the law of the Federal Republic of Germany applies to the exclusion of international sales law, in particular the UN sales law. The place of jurisdiction is Erlangen. Erlangen, as of October 21, 2018 Home Page

tVNS® Vagus Stimulasyon Cihazları ile ilgili ihtiyacınız olan bilgilendirme ve yönlendirmelerin olduğu içerik portali You can access the content portal, which contains the information and guidance you need regarding t VNS® Vagus Stimulation Devices, using the links below. If you are an individual tVNS user, please click on the "tVNS User Portal" link for your training and support needs. If you are a physician working on clinical research and different indication applications with our tVNS devices , please click on the "tVNS Clinical Portal" link. Welcome to tVNS Portal tVNS User Portal tVNS Clinic Portal

PATIENT DECLARATION FORM CLINICAL DIAGNOSIS & HEALTH CONDITIONS

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Cognitive Impairment Groundbreaking Technologies for Life What is Cognitive Impairment? The shrinkage caused by the loss of cells in the brain causes various functional disorders. These dysfunctions may manifest as dementia, Alzheimer, and mild cognitive impairment, which are common in people ives. People with cognitive impairment are at high risk for Alzheimer and dementia. When adequate precautions are taken, cognitive impairment may regress, and it is possible for these people to lead a normal life. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Cognitive Disorder Dementia It is the inadequacies experienced in language, skills and orientation, especially forgetfulness. Dementia is a family that includes many different types. There are Alzheimer's, dementia due to chronic cerebrovascular disease, alcoholic dementia, depressive dementia, dementia due to infections, etc. Dementia occurs as a result of general deterioration of the upper level functions of the cerebral cortex, especially over 75 years of age, with advancing age. There are dementias that start with memory impairment such as Alzheimer's disease, as well as behavioral disorders, skill disorders, depression, There are also dementias that start with the symptoms of parkinson's disease and language disorders. It is a progressive disease. Alzheimer It is the most common type of dementia is a neurological disease that causes the destruction of brain cells. The disease, which causes a decrease in thought, memory and behavioral functions, occurs after a long time with advancing age. It may take years for the disease to reach advanced stages. Because it is a progressive disease, Alzheimer's patients experience problems such as inability to perform their daily tasks, forgetfulness and serious confusion. People with memory loss or other possible Alzheimer's symptoms may have trouble recognizing that they have a problem. Treatment Options for Cognitive Disorder There is no drug therapy approved to treat cognitive impairment. Medicines used to treat symptoms of Alzheimer's disease have been tried. Some studies have found that using these drugs for cognitive impairment is helpful, while others have concluded that there is no benefit. It has been noted that the use of other drugs, including NSAIDs, Ginkgo, Biloba and vitamin E, does not provide a great benefit. tVNS Effect Mechanism There are many clinical studies in recent years that cognitive disorders are caused by inflammation in the brain. Although the basic efficacy mechanism of tVNS has not been fully resolved, our new generation devices in 2021 became the first neuromodulation therapy approved for cognitive impairment in the world, due to both its benefits in the treatment of inflammation and the increase in neuroplasticity. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır INSOMNIA (SLEEP DISORDER) Groundbreaking Technologies for Life What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Tinnitus and Vagus Nerve Stimulation Is tVNS® treatment painful? No. The tVNS® device delivers mild electrical impulses through the ear. Patients typically feel this as a tingling or gentle vibration. Do I need to use the device every day? Yes, regular use is important for optimal treatment results. The duration and frequency of application are determined by factors such as the patient's age and indication. Are there any side effects? Side effects of tVNS® treatment are generally mild. A rare side effect is mild skin irritation at the application site. How long does it take to see results? Some patients experience positive changes in sleep and mood within the first weeks, while reductions in tinnitus intensity may be noticeable within a few weeks to months. Tinnitus and Vagus Nerve Stimulation Individuals whose sleep and quality of life are impaired due to tinnitus Those seeking treatment without medication or surgery Patients with high psychological impact (anxiety, restlessness) Users who prefer a minimally invasive and safe method Contact us Contact us

PATIENT DECLARATION FORM CLINICAL DIAGNOSIS & HEALTH CONDITIONS

Transkutanöz Vagus Sinir Stimülasyonu (tVNS), vagus sinirine bir kulakluk yardımıyla elektriksel uyarılar verilmesini içeren tıbbi bir tedavidir . Dirençli epilepsi, kronik migren ve ilaca dirençli depresyon için etkili bir tedavi olarak kullanılır. What is Vagus Nerve? Discover The vagus nerve is the longest cranial nerve in the body. It comes from the Latin word, vagus, for “wandering.” That’s because it wanders throughout your body, with wide distribution connecting the brainstem to the body. Only mammals have this nerve. The vagus nerve serves as the body's superhighway, carrying information between the brain and the internal organs and controlling the body's response in times of rest and relaxation. It helps the immune system and inflammation response to disease. It has four main functions: sensory, special sensory, motor and parasympathetic. The vagus nerve also manages fears and sends information from the gut to the brain, which is linked to dealing with stress, anxiety, and fear–hence the saying, ‘gut feeling'. Historical Development of Vagus Nerve Stimulation Epilepsy has existed in human history with the first record found in a Babylonian text written 4000 years ago, and humanity has sought a cure for this disease for centuries. With the emergence of neurology in the 19th century, the mechanism between the nervous system and epilepsy was tried to be solved and the first vagus nerve stimulation was tried by a New York neurologist in the early 1880s. Over the next 100 years, the effects of vagus nerve stimulation were first investigated in animal experiments, then in humans, and in 1996, the vagus nerve was surgically implanted into the body and become an invasive stimulation option. At the beginning of the 2000s, for eliminating the side effects of invasive VNS, scientists tried to find out ways to stimulate the vagus nerve non-invasively, and by 2010 these studies were concluded successfully. Our first generation device, Nemos, was approved in 2010 for the treatment of epilepsy and depression, and Vitos in 2012 for the treatment of pain and migraine, as the first medically approved non-invasive vagus nerve stimulation treatment in the world. Our 2nd generation device, tVNS-L, has been approved in 2021, and has become a treatment option used in many neurodegenerative diseases. Vagus Nerve Stimulation Effect Overview Regulation of neurotransmitter release Increase in parasympathetic activity Increase in brain neuroplasticity Reducing inflammation Increasing the secretion of serotonin and increasing the mood What Are the Effects of Vagus Nerve Stimulation? Stimulation of the vagus triggers regulatory mechanisms in the nervous, immune, autonomic, endocrine, cardiorespiratory, and gastrointestinal systems. Clinical studies on the vagus nerve have shown that the activity in this nerve is closely related to epilepsy, depression, migraine, headache, inflammatory bowel disease, Alzheimer's, arthritis and many other common disorders by activating the parasympathetic nervous system in the brain and increasing the secretion of neurotransmitters in special regions of the brain. shows. Vagus nerve stimulation therapies are approved by FDA in the USA and CE in Europe for use in treatments such as mood improvement, pain relief, sleep improvement, memory enhancement and anxiety reduction. Research continues on the effects of neuroplasticity as well as its cardiac and inflammatory properties. Contact us