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PATIENT DECLARATION FORM CLINICAL DIAGNOSIS & HEALTH CONDITIONS Please click the button to download the guide: Download document

FAQs Frequently Asked Questions Am I suitable for treatment with tVNS®? 1 tVNS® is a non-invasive device used in the treatment of sympathetic vagal imbalances. It can be used in patients of all ages from 3 years of age. It can be used at any age from newborns with the approval of the doctor. In general, whether you are suitable for treatment is a decision that you will make in consultation with your doctor. If your doctor does not recommend or does not know the treatment, you can contact us. We can contact your doctor . What does it mean for the tvNS® device to be medically approved? 2 The manufacturer of the tVNS® therapy device, Germany-based tVNS Tehnologies GmbH, was established in Germany in 2003 and, as the world's pioneer of this technology, manages the worldwide clinical research and operations of the devices that have received the first medical approval in the world since 2010. With the medical approvals received in 2021 and 2023, it is the only auricular stimulation device that can safely apply vagus nerve treatment and is produced with the latest engineering technologies with the R&D and production team in Erlangen, Germany. Stimulation of the vagus nerve with devices that do not have safety and medical approval can lead to very serious consequences ranging from respiratory to cardiac arrest. Do I need to consult my doctor or device manufacturer for device settings when starting to use tVNS®? 3 No. tVNS® is very easy to use. It can be easily adjusted without the support of a doctor with the device training and instructions for use. When you receive the device, approximately 2 hours of device usage training is given. Afterwards, all settings related to the device are made by Turkey with a remote Bluetooth-supported application. Your therapy protocol is shared with your doctor on a regular basis. How often do I need to use tVNS®? 4 Therapy with tVNS® requires a total of 2 to 4 hours of sessions per day, depending on the indication used. The duration of these sessions can be planned as 1.5 hours. The time at which it will be is determined according to both the indication used and the daily routines and needs of the patient. What side effects might I experience? 5 Therapy with tVNS® is a treatment with very few side effects. In general, two types of side effects are observed. The first of these is local side effects that may occur in the form of itching, redness and pressure sores in the area where the outer auricle is stimulated. On the other hand, since the stimulation of the vagus nerve can affect the autonomic nervous system, systemic side effects may occur. These may include headache, nausea, or dizziness. As with other drug or neurostimulation treatments, an increase in seizures may occur. However, it differs from other treatments in that the side effects usually disappear soon after the end of treatment. Can I avoid taking medication if I choose tvNS ® treatment? 6 tVNS® therapy is an adjunct to medication, if you decide to stop or reduce your medication you should discuss this with your doctor. In general, it is not recommended to start a new drug, increase or decrease the dose, or start it simultaneously with another treatment at the time of initiation of treatment. In this way, we can observe the effects of tVNS® more objectively. How long will I need to use tVNS® treatment and how long will it take for the treatment to work? 7 tVNS® treatment is not an acute treatment, there is no external drug intake. It provides a long-term treatment option by stimulating certain centers of the brain and increasing the release of neurotransmitters over time, eliminating the sympathovagal imbalance. Like most drugs and neuromodulatory therapies for epilepsy treatment, tVNS® therapy is a long-term therapy. Even if you do respond to treatment with tVNS®, the effect usually starts with a delay of just a few weeks to months. Can tVNS ® be used by children? 8 tVNS® can be safely used by children under parental supervision. It was applied to two different 8 and 9 months old babies with the approval of a doctor in Turkey and no negative results were encountered. If it will be used with children, the sessions must be given under parental supervision. tVNS® can be used by children 6 years and older. If it is to be used in children younger than 6 years old, the sessions must be performed under the supervision of the parents. How can I access tvNS ® ? 9 If deemed appropriate by your doctor for the treatment of tVNS®, you can apply to our center and obtain the device. After planning how to use the device and the treatment protocol, you can start the treatment by receiving remote treatment support. 1 0 What are the approved indications of the device? Indicated since 2021 for Anxiety, Migraine, Autism, Cognitive Impairment, Depression, Fibromyalgia, Epilepsy, Inflammation, Prader-Willi Syndrome, Sleep Disorders, Stroke, Tinnitus, Asthma, Crohn's Disease, Atrial Fibrillation and Parkinson's. Apart from this, researches continue on different subjects such as neural plasticity, coma and diabetes. To what extent does tVNS ® treatment affect epileptic seizures? 11 According to clinical studies conducted in 2000 patients using the tVNS® device between 2010 and 2018, a significant reduction in the severity and number of seizures was observed in an average of 60% of the patients. It can be said that a secondary effect, which is widely seen, is an increase in vitality, cognitive progress and improvement in sleep patterns. It can completely stop seizures in 10-20% of patients. What are the indications (effects) of the t-VNS ® device? 12 1) It undertakes the task of increasing the activity of the parasympathetic nervous system (resting mode). 2) It provides the balance of neurotransmitter hormone that the body cannot produce enough. 3) It helps to increase brain plasticity (Neural plasticity /: the ability of the brain to undergo structural or physiological changes) in the medium and long term. 4) Reducing inflammation. In recent years, clinical studies of tVNS® have proven the inflammatory effects of nerve stimulation. Inflammation (colloquially known as inflammation/inflammation) in the simplest terms, against all kinds of foreign factors or internal-external tissue damage of living tissue; cellular (cellular), body fluid (humoral) or veins (vascular) are some series of reactions on the basis. By developing inflammation, the body actually aims to destroy the disease factor, to isolate the factors that it cannot destroy from healthy tissues or to eliminate damaged tissues. It is divided into acute and chronic inflammation. Examples of acute inflammation: Redness, swelling, fever, pain, edema, increased temperature Examples of chronic inflammation: Cancer, ALS, heart diseases, diabetes, hypertension, asthma, depression, neurological diseases Is the response time of vagal stimulation therapy (vagus nerve stimulation) the same in patients of all ages? 13 It has been observed that the earlier the patient starts vagal nerve stimulation therapy or the shorter the epilepsy history, the shorter the response time to the disease. For example, a 40-year-old epilepsy patient may take longer to respond to vagal nerve stimulation treatment than a pediatric epilepsy patient. Is nonsurgical tVNS (through the skin) vagus nerve stimulation) only a preliminary step for patients responding to surgical VNS therapy? Should epilepsy patients who respond to cutaneous vagus stimulation therapy switch to invasive therapy? 14 tVNS® therapy may be a preliminary step for invasive vagal nerve stimulation requiring surgical intervention, but it is also an alternative treatment modality. The reasons for this are; I. Not every patient is suitable for invasive intervention. II. In case of failure to respond to treatment, removal of the electrode is difficult and risky, as the tissues of the vagus nerve wrap and fuse with the electrode. Even if the battery is removed, the patient will have to live with an inactive implant electrode in his body for life. It may cause pain or pressure, and infection may develop over time. Can the transcutaneous (through the skin conduction/non-invasive) method and the Invasive (surgical implant) method give the same effect in vagal nerve stimulation? 15 According to fMRI studies, it has been proven that both methods stimulate the same points in the brain. However, tVNS® has some advantages over the invasive method: 1. Contrary to the invasive alternative, since it has a rechargeable battery, it can give electrical stimulation as more frequent and intense programs. 2. As with the invasive alternative, high currents up to 5MA can be given, as it does not directly give the electric current attached to the nerve and does not pose the risk of nerve damage. Why does not every patient respond to his treatment in the same way or at the same rate? 16 There are different hypotheses about this, one of them is myelin thickness. Thick myelin nerves conduct electrical conduction better, and in this way vagus nerve stimulation can be done more effectively. Myelin thickness can vary from person to person genetically. Studies have shown that patients with thick myelin nerves respond better to treatment. What is the direct current (milliamps) to stimulate the ear? 17 There are scientifically proven studies on this subject. The minimum electrical current required to stimulate the vagus nerve is kept somewhat below the pain/pain threshold so that it does not activate the pain nerves. For this reason, there should be no pain or pain during stimulation, but a distinct vibration sensation. This is the most optimal stimulation intensity and should be at a level that does not disturb the patient. In which situations can the device not be used during the day? 18 You can safely use the tVNS® device while mobile, while walking, watching TV, reading a book, or at the computer. For safety reasons, it is recommended not to be used while driving to avoid distractions. It is recommended that the device be turned off when passing near high magnetic fields and devices that create high magnetic fields. Apart from this, it can be used in children both while they are asleep and awake. Adults are advised not to sleep while performing self-therapy. In order to avoid the risk of any cable entanglement around the neck, our children can be given therapy both while awake and asleep under parental supervision. Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Cognitive Impairment Groundbreaking Technologies for Life There is no drug therapy approved to treat cognitive impairment. Medicines used to treat symptoms of Alzheimer's disease have been tried. Some studies have found that using these drugs for cognitive impairment is helpful, while others have concluded that there is no benefit. It has been noted that the use of other drugs, including NSAIDs, Ginkgo, Biloba and vitamin E, does not provide a great benefit. tVNS Effect Mechanism There are many clinical studies in recent years that cognitive disorders are caused by inflammation in the brain. Although the basic efficacy mechanism of tVNS has not been fully resolved, our new generation devices in 2021 became the first neuromodulation therapy approved for cognitive impairment in the world, due to both its benefits in the treatment of inflammation and the increase in neuroplasticity. Types of Cognitive Disorder Dementia It is the inadequacies experienced in language, skills and orientation, especially forgetfulness. Dementia is a family that includes many different types. There are Alzheimer's, dementia due to chronic cerebrovascular disease, alcoholic dementia, depressive dementia, dementia due to infections, etc. Dementia occurs as a result of general deterioration of the upper level functions of the cerebral cortex, especially over 75 years of age, with advancing age. Treatment Options for Cognitive Disorder Improving memory and attention processes by increasing prefrontal cortex and hippocampal activity Increasing attention and alertness via the noradrenergic system Protecting nerve cells with anti-inflammatory effects (neuroprotection) Reducing stress-induced cognitive impairment by increasing parasympathetic activity Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Findings from Neuroimaging Studies Hafıza ve Öğrenmede Artış MCI ve Demans Riski Altındaki Bireylerde Potansiyel Faydalar fMRI Bulguları ile Desteklenen Beyin Aktivitesi Artışı What is Cognitive Impairment? The shrinkage caused by the loss of cells in the brain causes various functional disorders. These dysfunctions may manifest as dementia, Alzheimer, and mild cognitive impairment, which are common in people ives. People with cognitive impairment are at high risk for Alzheimer and dementia. When adequate precautions are taken, cognitive impairment may regress, and it is possible for these people to lead a normal life. Targeted Cognitive Benefits with tVNS® Memory Improvement in short-term and long-term memory Attention Increased attention and concentration Learning Increased capacity to learn new information Cognitive development Improvement in mental flexibility and decision-making processes Focusing Reduction of stress-induced cognitive clouding These effects make tVNS a valuable supportive tool, especially for older adults, those with post-traumatic cognitive impairment, those with post-depressive cognitive decline, and individuals diagnosed with MCI. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home Hasta tarafından günlük olarak, kendi ev ortamında kolaylıkla kullanılabilir. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Uyarım parametreleri hastaya özel olarak ayarlanabilir. Contact us Contact us

Vagus nerve stimulation for depression DEPRESSION Groundbreaking Technologies for Life What is Depression? Depression is a mood disorder that causes constant sadness and loss of interest. Depression is also called major depressive disorder or clinical depression. The feelings, thoughts and behaviors of individuals suffering from this condition are affected and various emotional or physical problems may arise due to this. There may be problems doing normal daily activities, and sometimes life may seem not worth living. Depression is not just a feeling of malaise or momentary weakness. Depression is also not such a simple problem that it can be solved in an instant. Depression is a treatable medical condition that requires treatment. This treatment process may take a long time in some cases. Everyone goes through periods of not feeling well emotionally and psychologically from time to time. These periods generally last for a certain period of time, depending on the intensity of the troubles and sorrows you experience. However, if your bad periods last longer than two or three weeks and prevent you from doing many of the things you do in your daily life properly; this condition is called depression (major depressive disorder). Targeted Benefits in the Treatment of Depression with tVNS® Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Why Are Alternative Treatment Options Needed? Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. Meet tVNS®: A New Approach to Depression Through the Vagus Nerve Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. During migraine, the cerebral vessels first narrow and then expand. The increase in pressure due to enlargement in the brain vessels is the cause of the throbbing finding in the person. " The scientific solution for depression: tVNS®. The life of a 17-year-old girl diagnosed with medication-resistant, suicidal depression was completely changed by transcutaneous vagus nerve stimulation. This clinically proven, non-invasive method is especially promising for young individuals. It enables the safe management of depression by affecting the brain's mood centers via the vagus nerve. Key Features of tVNS®: Clinically proven effectiveness, non-invasive and drug-free therapy, the ability to monitor your recovery process, and suitability for pediatric use. " Who is it suitable for? tVNS® can be a complementary solution in the following situations: Individuals experiencing mild, moderate and severe depression Those who do not benefit sufficiently from drug treatment Those seeking alternatives due to drug side effects Those who experience depression along with anxiety and sleep disturbances What is Depression? What is Depression? Depression is a mood disorder that causes constant sadness and loss of interest. Depression is also called major depressive disorder or clinical depression. The feelings, thoughts and behaviors of individuals suffering from this condition are affected and various emotional or physical problems may arise due to this. There may be problems doing normal daily activities, and sometimes life may seem not worth living. Depression is not just a feeling of malaise or momentary weakness. Depression is also not such a simple problem that it can be solved in an instant. Depression is a treatable medical condition that requires treatment. This treatment process may take a long time in some cases. Everyone goes through periods of not feeling well emotionally and psychologically from time to time. These periods generally last for a certain period of time, depending on the intensity of the troubles and sorrows you experience. However, if your bad periods last longer than two or three weeks and prevent you from doing many of the things you do in your daily life properly; this condition is called depression (major depressive disorder). Adolescence is a critical period when depression most frequently begins and treatment-resistant cases are observed. Safe and non-invasive options are needed for adolescents who fail to respond to traditional treatments. Transcutaneous auricular vagus nerve stimulation (taVNS) is a new method that can be applied without the need for surgery by stimulating the vagus nerve through the ear. In this study, a 17-year-old girl with treatment-resistant depression received taVNS treatment for 7.5 months, with daily sessions at home, in conjunction with escitalopram therapy, and under regular monitoring by the clinical team. A total of over 270 sessions were administered, with an average daily use of approximately 3 hours. Aside from mild skin irritation, no serious side effects were observed, and cardiac safety tests were normal. Depression severity decreased during treatment, both as assessed by self-report and clinician assessments. The patient completed high school and entered university, and partial improvements in functioning were noted. The results suggest that taVNS is a feasible, safe, and promising complementary treatment option for adolescents. Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. Types of Depression Symptoms Types of Depression The symptoms caused by major depression are different for each individual. Medical professionals look for various markers or traits that clarify an individual's type of depression. A marker or feature may indicate the presence of a particular type of depression: Anxiety distress : Unusual restlessness or depression with worry about possible events or loss of control. Atypical features : Depression with temporary happiness from certain events, increased appetite, excessive need for sleep, hypersensitivity to rejection, and a feeling of heaviness in the organs. WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us Contact us

tVNS Vagus Stimulation Devices Information Request Form Name Surname Your E-mail Address Phone Number Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible. Home Page

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Migraine Symptoms, Causes and Diagnostic Methods Migraine Symptoms Migraine symptoms usually begin in the teenage years. The probability of its occurrence increases from the last stages of adolescence, and this probability decreases after the age of 35. As it is known in people with migraine, the most common and most severe symptom is headache. This headache can sometimes be so severe that it puts the person in bed. The most common areas of migraine attacks are the back of the head, behind the ears and forehead. Other physical symptoms of migraine are the desire to drink excessively, increase in appetite, diarrhea or constipation depending on the situation, and swelling in the abdomen. In addition to these physical symptoms, people who experience migraine attacks also experience various emotional symptoms. Symptoms such as depressed mood, excessive cheerfulness, excessive stagnation, concentration disorders, olfactory sensitivity, attention deficits, hypersensitivity and an intense desire for sleep can be seen. Migraine Causes Migraine is a genetically inherited disease. In other words, migraine is more common in people with a family history of migraine. Although not in the family, women are at risk for migraine headaches during hormonal transition (adolescence, premenstrual days, menopause) and during the periods when they use birth control pills. . The sensory nerve of our face, cerebral vessels and cerebral cortex is the same. This nerve can also be stimulated in external environment triggers and trigger pain mechanisms in the brain. Triggers of Migraine Hormonal changes experienced by women Hormone medications, such as oral contraceptives (birth control pills) and hormone replacement therapy Some foodstuffs Stress plays an important role in migraine attacks. Stress at work or home life may be the cause of frequent migraine attacks. Loud noises, bright lights, or exposure to sunlight Changes in sleep and wake patterns Migraine attacks may occur with sexual activity or intense physical exertion. Ambient air pressure or barometric changes can trigger migraines. Medicines; Vasodilators (vasodilators) such as nitroglycerin or oral contraceptives (birth control pills) can worsen migraines. Brain tumor Migraine Diagnostic Methods Diagnosis is made during the interview by a specialist physician. If you are experiencing any of the following symptoms, you should see a doctor immediately; Sudden, severe headache like thunder Fever, stiff neck, confusion, double vision, drowsiness, or slurred speech Worsening of headache, especially after a head injury A headache that develops after coughing, exertion, straining, or a sudden movement New onset headache over 50, Migraine is not known enough and its treatment is not done because patients do not apply to the neurology department and try to control their headaches with painkillers. If you regularly experience migraine attacks and symptoms, it is useful to record them. If you think that the attacks and severity of your headaches have changed, you should definitely see a neurologist as soon as possible. For the diagnosis of epilepsy, the patient's medical history, frequency and severity of seizures, and symptoms are among the points that physicians pay attention to. Sometimes, extreme stress, fatigue, emotional and hormonal changes can also cause seizures. In this sense, not every seizure indicates epilepsy. Physicians can diagnose after listening to patients' stories. Genetic factors take the first place among the causes of migraine headaches. The incidence of migraine in patients with a family history of migraine varies between 40% and 75%. Hormonal changes also cause an increase in migraine attacks. Migraine attacks are 3 times more common in women than in men. Migraine Who has visible Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır INSOMNIA (SLEEP DISORDER) Groundbreaking Technologies for Life What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Treatment Options for Insomnia What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Treatment Options for Insomnia Uykuya Dalma ve Sürdürme Sürelerinde İyileşme Parasempatik Aktivitenin Artışı Uyku Kalitesinde Objektif Artış What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Sleep Tests Air flow in and out of the lungs during breathing Blood oxygen levels. Body position. More information CPAP Titration (Mask Therapy) In some cases of severe depression, hospitalization is necessary. This may be necessary if the individual is unable to care for themselves properly or is in danger of harming themselves or others. More information Polysomnography In other words, a sleep test is a procedure that uses devices to record sleep throughout the night to determine the quality of sleep and identify the cause of sleep disturbances. More information Transcutaneous Vagus Nerve Stimulation (tVNS) The vagus nerve facilitates communication between the gut and the brain. When you're unhappy, the vagus nerve senses that something is wrong and activates the sympathetic nervous system, a key component of the digestive system, which then releases cortisol. More information What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which d iffers from person to person, can change the person's sleep duration. Types of Insomnia Acute insomnia : It refers to the short-term appearance of insomnia. Acute insomnia usually occurs after a stressful day or on days when mental tension is high. Our body clock has a har d time showing when it's time to rest on such difficult days. This irregularity, which usually lasts for 1 to 2 days, continues until we feel better. There are signs of acute insomnia that can last up to 4 weeks. Application, Security and Approval Process Minimal Side effect The device is applied through the ear, does not require surgery and has minimal side effects. Possibility of Application at Home It can be easily used by the patient on a daily basis in his or her own home environment. Approved and Safe Approved as a Class IIa medical device under the European Union MDR 2017/745 Complementary to Drug Therapy It can be used alongside drug therapy; there is no need to interrupt treatment. Personalized Therapy Stimulation parameters can be adjusted individually to the patient. Contact us Contact us

tVNS Transkutanöz Vagus Sinir Stimülasyonu cihazıdır. Dirençli Epilepsi, Migren ve Depresyon Tedavisinde Ameliyatsız İlaçsız Kulaktan Vagus Sinirini Uyaran Dünyanın CE onaylı Tek Nöroterapi - vagus stimulasyonu- cihazıdır. tVNS Türkiye , "t-vnstherapy "tek yetkili satıcısıdır. Changing the World, Changing the Lives In More than 50 Countries of the World With Our 20 Years of Vagus Treatment Experience We Are Here for a Brand New Quality of Life Our tVNS® health solutions help thousands of patients to discover a brand new quality of life. What is tVNS®? tVNS® is a medical device for the treatment of symptoms of sympathovagal imbalance and was specially developed for patients who are not free of symptoms despite drug therapy. tVNS® stimulates the branch of the vagus nerve in the auricle through the skin with gentle electrical impulses. Signals are passed on to the brain via special nerve fibers: first in the brain stem and then in higher centers. The treatment with tVNS® is applied by patients independently. It has been used by thousands of patients and is a treatment with very few side effects. tVNS® is indicated to treat sympathovagal imbalance in the following conditions: Anxiety Migrain Autism Cognitive Impairment Depression Fibromyalgia E p ilepsy Inflammation Pr ader-Willi Syndrome Sleep Disorders Stroke Tinnitus Asthma Crohn's Disease Atrial Fibrillation Parkinson's tVNS® CARE Therapy Tracking THE MOST EFFECTIVE WAY TO GET RESULTS FROM tVNS®* For patient-driven medical device treatments that the patient can apply at home without the supervision of a doctor, the most important need for the success of the treatment is the preparation of a protocol specific to the patient's needs and the remote follow-up by the doctor and an expert team to see whether the patient can use the device correctly. tVNS Care®, o ur unique digital health service, where a patient-specific program is prepared based on the protocols of similar patients in more than 50 countries and all details of the treatment can be followed online by our expert teams. Why Treatment with tVNS® Device? Customized Therapy t VNS® therapies are customized for each patient, based on indication and needs, so can provide a unique solution for every patient. More Flexibility With the help of the rechargeable battery, it allows several different parameters and treatment protocols. Innovative App With the tVNS® Patient App you can track your treatment, share results with your doctor and get therapy consultation wherever you are R emote Training tVNS® allows remote delivery and training without any need for travel, so that any patient can start using the therapy on their home No Surg ery tVNS® enables non-surgical vagus nerve stimulation with full patient control and no invasive- risks Few Side Effects tVNS® has very few side effects compared to drugs and invasive treatments, and easily tolarable. Pediatric Flexibility It can be used safely at any age from newborn babies with the approval of the doctor. Easy to Use tVNS® is easy to use, as small as a smartphone and can be easily integrated into everyday life. Treatment Stories of tVNS® Patients Our doctor Barış Ekici has contributed a lot to my autistic son Kaan. We have benefited greatly from the tVNS treatment, which is Vagus nerve stimulation. We have seen progress in his word count and awareness. He has become calmer, his hyperactivity has decreased, and his sleep has become more regular. Dr. Nurbanu Gürbüzer, Istanbul, Assoc. Prof. Dr. Barış Ekici, mother of a patient followed up Download the tVNS ® Patient App Meet the Tele-Medicine Technologies of the Future With the innovative tVNS® patient app, you can track your treatment at any time and share your data with your doctor. In addition, the tVNS® patient app enables us to continuously improve our technology and optimize your treatment. The tVNS® Patient App is available now in the Google Play Store and in the Apple App Store (EU-only). How does tVNS® work? You can use tVNS® anytime, anywhere. It is easy to use, portable and discrete. tVNS® activates special nerve fibers through gentle electrical impulses (neurostimulation) via an ear electrode on the ear, stimulating the branch of the vagus nerve in the auricle through the skin, by sending nerve signals to the brainstem and the higher centers. This alleviates symptoms of sympathovagal imbalance, for example reducing seizures in epilepsy. Watch this short video to learn more about our tVNS® health solutions and how tVNS® works. blog Contact us Name Surname Where did you hear about us? * Internet search tVNS social media (Facebook, instagram) My Follow-Up Doctor Others Which topic do you need to be informed? * Epilepsy Migraine Depression Research Device Your E-mail Address Phone Number Patient's diagnosis history (Diagnostic, medications, follow-up doctor...etc.) Submit Thank you for your interest in tVNS Turkey. We will respond to you as soon as possible. Contact us

DEPRESSION Groundbreaking Technologies for Life " The scientific solution for depression: tVNS®. The life of a 17-year-old girl diagnosed with medication-resistant, suicidal depression was completely changed by transcutaneous vagus nerve stimulation. This clinically proven, non-invasive method is especially promising for young individuals. It enables the safe management of depression by affecting the brain's mood centers via the vagus nerve. Key Features of tVNS®: Clinically proven effectiveness, non-invasive and drug-free therapy, the ability to monitor your recovery process, and suitability for pediatric use. " What is Depression? Depression is a mood disorder that causes constant sadness and loss of interest. Depression is also called major depressive disorder or clinical depression. The feelings, thoughts and behaviors of individuals suffering from this condition are affected and various emotional or physical problems may arise due to this. There may be problems doing normal daily activities, and sometimes life may seem not worth living. Depression is not just a feeling of malaise or momentary weakness. Depression is also not such a simple problem that it can be solved in an instant. Depression is a treatable medical condition that requires treatment. This treatment process may take a long time in some cases. Everyone goes through periods of not feeling well emotionally and psychologically from time to time. These periods generally last for a certain period of time, depending on the intensity of the troubles and sorrows you experience. However, if your bad periods last longer than two or three weeks and prevent you from doing many of the things you do in your daily life properly; this condition is called depression (major depressive disorder). SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Depression The symptoms caused by major depression are different for each individual. Medical professionals look for various markers or traits that clarify an individual's type of depression. A marker or feature may indicate the presence of a particular type of depression: Anxiety distress : Unusual restlessness or depression with worry about possible events or loss of control. Atypical features : Depression with temporary happiness from certain events, increased appetite, excessive need for sleep, hypersensitivity to rejection, and a feeling of heaviness in the organs. Mixed features : High self-esteem, and energetic mania concurrent with depression involving too much talk Catatonia : Depression with uncontrollable motor activity and purposeless movements or with fixed and rigid postures. Melancholic features : Depression, which is seen as a cooling reaction to something that once brought pleasure, depression that may be accompanied by worsening mood, weakness or agitation during waking up early in the morning. Seasonal features : Depression triggered by seasonal changes and less exposure to sunlight. Peripartum onset : depression that occurs during pregnancy or in the weeks or months after birth, that is, in the "postpartum" period Psychotic features : depression accompanied by personal inadequacy or other negative delusions or hallucinations Treatment Options for Depression Drug Therapy The medications to be used during depression treatment should be determined under the supervision of a doctor. More information Hospital Treatment In some cases of severe depression, hospitalization is necessary. This may be necessary if the individual is unable to care for themselves properly or is in danger of harming themselves or others. More information Psychotherapy It is a general term used for an individual pursuing treatment for depression by talking with a mental health professional about their condition and related issues. More information Transcutaneous Vagus Nerve Stimulation (tVNS) Increased parasympathetic activity promotes relaxation and well-being. Increased serotonin release also boosts mood. More information WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır Crohn's Disease Groundbreaking Technologies for Life Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. What Can tVNS® Do for Crohn's? " The scientific solution against Crohn's disease and Irritable Bowel Syndrome (IBS): tVNS® Transcutaneous vagus nerve stimulation has yielded promising results in many patients diagnosed with Crohn's disease and IBS, which are resistant to medication and severely reduce their quality of life. This clinically proven, non-invasive method contributes to the safe management of gastrointestinal symptoms by regulating the gut-brain axis. It stands out as a new treatment option, particularly for chronic intestinal disorders . Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. May reduce the release of proinflammatory cytokines such as TNF-α, IL-1β and IL-6 Can suppress the inflammatory activity of macrophages It can re-establish the immune balance in the intestinal mucosa In a 2016 study conducted by Bonaz and colleagues, seven individuals with active Crohn's disease received chronic vagus nerve stimulation (VNS) therapy for six months. The primary goal of the study was to achieve clinical remission (reduction of CDAI scores), while secondary goals included immune markers (CRP and/or fecal calprotectin) and endoscopic improvement, as well as restoration of vagus nerve tone (as measured by heart rate variability). Stimulation was well tolerated by all patients, with no significant side effects. Two patients were withdrawn from the study three months into treatment due to clinical worsening. The remaining five patients experienced both clinical remission, biological improvement, and endoscopic improvement, and vagal tone was restored. These results provide initial evidence that VNS may be a feasible, safe, and effective treatment option for active Crohn's disease. What is Crohn's Disease ? Crohn's disease is a type of inflammatory bowel disease that causes inflammation of the gastrointestinal tract from the mouth to the anus. This inflammation can be attached to one or more parts of the digestive system, but it is usually seen in the ileum, which is the last part of the small intestine, and in the beginning of the large intestine. Crohn's disease can cause inflammation in your digestive tract, leading to abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition. Growth-development retardation in children may be signs of Crohn's disease. Extra-intestinal diseases are also observed in a quarter of Crohn's patients. These mostly occur in the skin, joints, eyes, liver and biliary tract, kidney and urinary tract, vascular heart and lungs. Crohn's Disease Symptoms Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Crohn's Disease Diagnostic Methods Blood analysis stool analysis Stomach, small and large intestine films Colonoscopy and endoscopy CT and MRI images Crohn's Disease Diagnostic Methods Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Corticosteroids Immunosuppressants Aminosalicylates Biological agents (anti-TNF α) Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Clinical Response in Human Studies In a study by Bonaz et al. (2016), a significant decrease in disease activity scores (CDAI) was noted in the majority of Crohn's disease patients who underwent tVNS. At 6-month follow-up, clinical remission was achieved in more than 60% of the tVNS group. No side effects were observed in this study, and patients' quality of life also improved. Changes in Immune Profile and Cytokine Responses While pro-inflammatory cytokine levels decreased in patients undergoing tVNS, an increase in anti-inflammatory IL-10 levels was detected. A Drug-Free and Safe Alternative tVNS offers a promising approach, especially for patients who do not respond to immunosuppressive therapy, who are discontinuing medication due to side effects, or who wish to avoid surgery. Crohn's Disease Causes Immune system: It is possible for a virus or bacteria to trigger Crohn's disease; however, scientists have yet to identify such a trigger. When your immune system tries to fight off the invading microorganism, an abnormal immune response can cause the immune system to attack cells in the digestive tract as well. Heredity: Crohn's disease is more common in people with a family history of the same disease, so genes may play a role in the occurrence of the disease. 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tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır EPILEPSY Breakthrough Technologies for Life What is Epilepsy? Epileptic seizure (or seizure) is a clinical condition that occurs when the normal activity of the brain is disrupted as a result of temporary abnormal electrical activity in nerve cells. Epilepsy, also known as "Sara Disease" among the people, manifests itself with epileptic seizures. Epilepsy is a chronic disease. It develops in people who have brain damage during or after birth for any reason. It is a disease seen in 1% of the population in the world and in our country, and about 70% of these patients can be treated with epilepsy drugs called antiepileptic. More than 30 percent of all epileptic patients continue to have seizures despite taking appropriate medications (anticonvulsants) for epileptic seizures, a condition called refractory epilepsy. Several treatment options are available for patients in this condition. SYMPTOMS Read more REASONS Read more WHO IS SEEN IN Read more DIAGNOSTIC METHODS Read more Types of Epilepsy Doctors have described more than 30 different types of seizures, ranging from very brief shifts of attention to prolonged seizures. The frequency of seizures is also variable, with some patients having less than one seizure per year, while others may experience multiple seizures per day. Seizures are generally divided into two main groups (partial or generalized seizures) depending on the area of abnormal electrical activity in the brain. Partial Seizures: Partial seizures begin and affect only one part of the brain. Also known as 'focal', these seizures can be seen in the following ways. Secondary Generalized: A seizure that begins as a partial seizure and spreads to the rest of the brain, becoming a generalized seizure. Complex: The person experiences changes in consciousness and loss of consciousness, which causes confusion. The person may experience a dreamlike state or exhibit strange and repetitive behaviors such as emotional outbursts or blinks and tics. Generalized Seizures: Generalized seizures occur as a result of abnormal activity in both halves of the brain simultaneously. Absence Seizures: Associated with a shift of consciousness in which the person seems to be immersed in the void. This condition usually begins in childhood and is confused with attention deficit. Simple seizures: Despite seizure activity, the person is conscious and remains aware of those around them. An abnormal twitching, lethargy, sweating, drowsiness, nausea, disturbances of perception and memory, and a feeling of 'deja vu' may occur. Treatment Options for Drug-Resistant Epilepsy Epilepsy Surgery It is the surgical intervention of areas of the brain that cause epileptic seizures and do not perform their normal functions. More information Invasive Vagus Nerve Stimulation (iVNS) A pacemaker is surgically implanted under the chest and an electrode is placed in the vagus nerve in the neck. The electrodes stimulate the vagus nerve near the carotid artery at regular intervals. More information Antiepileptic Drugs They are designed to correct the chemical imbalance in brain cells that causes seizures. These medications work in different ways, some of which are not yet fully understood. More information Transcutaneous Vagus Nerve Stimulation (tVNS) It is a treatment option that stimulates the centers in the brain by stimulating the vagus nerve with the help of an electrode attached to the ear. More information WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

tVNS E - İlaca Dirençli Epilepsi için Ameliyatsız Tedavi. İlacın yeterli olmadığı durumlarda vagus sinir stimulasyonu tVNS E, dirençli epilepsi ve major depresyon tedavisinde kullanılan dünyanın tek onaylı non-invazif vagus terapi cihazıdır AUTISM Symptoms, Causes and Diagnostic Methods Autism Symptoms Lack of social communication Can't make eye contact They do not react to what is said lack of speech They do not feel danger and fear They don't look back when their name is called They tend to walk on their toes. Sensitivity to light and sound Causes of Autism Although the exact cause of autism has not been found, it is stated by experts as a genetic disease. Psychological problems experienced by the mother before birth, gene mutation, alcohol and cigarette use increase the risk of the baby having autism. Autism Diagnostic Methods Early diagnosis is very important in autism symptoms that show limited and repetitive behaviors. It is necessary to get help by monitoring the child's behavior by a specialist physician. Autism diagnosed at the age of 2 to 4 years has high reliability levels. Who Has Autism visible Autism is more common in boys than girls. Approximately 3.6% of boys and 1.3% of girls between the ages of 3 and 17 have autism spectrum. According to the data released by the World Health Organization in 2021, one out of every 160 children in the world is diagnosed with autism. Contact us